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Stem Cell Research Products - Opportunities, Tools & Technologies

出版日期 內容資訊 英文 175 Pages
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幹細胞的研究產品:機會·工具·技術 Stem Cell Research Products - Opportunities, Tools & Technologies
出版日期: 2016年04月30日 內容資訊: 英文 175 Pages


第1章 摘要

第2章 調查目的

第3章 調查方法

第4章 幹細胞的研究產品發展的重要現象

第5章 幹細胞的種類

  • 人類胚胎幹細胞(hESC)
  • 胎生幹細胞(多功能)
  • 臍帶幹細胞(多功能)
    • 臍帶血
    • Cord Matrix (“Wharton's Jelly”)
  • 成體幹細胞(多功能)
    • 造血幹細胞
    • 間葉幹細胞
    • 神經系統幹細胞
    • 牙齒幹細胞
    • 脂肪幹細胞
  • 癌症幹細胞(多功能)
  • iPS細胞(iPSC)

第6章 幹細胞的研究用途

  • 基礎研究
  • 再生醫療
  • 藥物研發·開發

第7章 主要競爭企業:幹細胞產品市場

  • Thermo Fisher Scientific(含 Life Technologies,Invitrogen 其他領導品牌)
    • 收購
    • 合作
  • BD Biosciences
  • Merck KGaA
  • Miltenyi Biotec
  • E. STEMCELL Technologies

第8章 產品領域

  • 各類型產品類型
    • 一次抗體
    • 以微珠為基礎的細胞分離系統
    • 螢光為基礎的標籤·檢測
    • 蛋白質煉製·分析工具
    • DNA/RNA為基礎的特徵分析
    • 分離/特徵分析服務
    • 幹細胞培養基·試劑
    • 生長因子·細胞激素
    • 幹細胞遺傳基因控制
    • 體內/體外細胞追蹤
    • 培養/分化服務
    • 幹細胞株

第9章 幹細胞研究新的領域

  • iPS細胞
  • 臍帶血幹細胞
  • 牙髓幹細胞
  • 脂肪幹細胞

第10章 市場規模

  • 定義
  • 調查方法
  • 市場規模的估計
  • 市場規模的5年預測

第11章 市場趨勢分析

  • 臨床試驗分析
  • 臨床試驗分析:各年度
  • 臨床試驗分析:各地區
  • 臨床試驗分析:各細胞類型
  • 補助金分析
  • 專利分析
  • 科學出版物化率
  • 幹細胞計劃基金

第12章 市場趨勢:詳細的終端用戶調查

  • 調查概要
  • 市場調查受訪者的特徵分析
  • 調查結果:一般的範圍
  • 調查結果:應用幹細胞調查
  • 調查結果:供應商比較(品牌偏好)
  • 調查結果及分析

第13章 打入市場策略

  • 實施幹細胞研究的主要研究機關
  • 實施幹細胞研究的主要國家
  • 有關心的事件

第14章 幹細胞的社會分析

  • 銷售成本分析:按次付費點擊(PPC)分析
  • 過去12個月最常被社群媒體共享的幹細胞相關報導
  • Google趨勢的幹細胞相關資料
  • Twitterhash標籤資料
  • Twitter影響者前幾名5位

第15章 結論





This global strategic report evaluates strategies across the entire stem cell product spectrum, with emphasis on opportunities for stem cell research product development. It explores unique market opportunities by stem cell type, including mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs), neural stem cells (NSCs), and more.

The possibilities arising from stem cells have resulted in great commercial interest, with potential applications ranging from their use in the reversal of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, toxicology assessment, and more.

Several broad categories of stem cells exist, including:

  • Embryonic stem cells, derived from blastocysts
  • Perinatal stem cells, obtained during the period immediately before and after birth
  • Adult stem cells, found in adult tissues
  • Induced pluripotent stem cells, produced by genetically reprogramming adults cells
  • Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body

Traditionally, scientists have worked with both embryonic and adult stem cells as research tools. While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral and spiritual controversy surrounding their use. Although some adult stem cells do have differentiation capacity, it is often limited, which results in fewer options for use.

Thus, when induced pluripotent stem cells (iPSCs) were produced from mouse cells in 2006 by Shinya Yamanaka of Kyoto University in Japan, they represented a promising combination of adult and embryonic stem cell characteristics. By 2007, a series of follow-up experiments were done at Kyoto University in which human adult cells were transformed into iPSC cells. Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells.

At this time, the following account for the majority of stem cell research:

  • Basic Research - Understanding stem cell mechanisms and behavior
  • Regenerative Medicine- Use of stem cells for the reversal of injury or disease
  • Drug Target Validation and Drug Delivery- Validation of the predicted target using living cells
  • Toxicology Screening- Use of stem cells to evaluate effects of drugs on biological systems

To facilitate research resulting from interest in these potential far-ranging applications, a large and growing stem cells research products market has emerged.

Large companies selling stem cell research products include:

  • Thermo Fisher Scientific
  • BD Biosciences, a Division of Becton Dickinson
  • Merck KGaA
  • Miltenyi Biotec
  • STEMCELL Technologies
  • Lonza Group
  • Clontech (a Takara Bio Company)
  • GE Healthcare Life Sciences.

While several of these dominant market players have utilized acquisition strategies to grow and capture market share, Merck KGaA has had a particularly strong commitment to this approach, acquiring several other massive major players within the stem cell research products marketplace, including Milllipore on February 26, 2010, for $7.2 billion, and Sigma-Aldrich on September 22, 2014, for $17 billion. Dozens of mid-sized suppliers of stem cell research products also exist, as well as over 100 small specialty providers.

Currently, the following compose the majority of stem cell research product sales worldwide:

  • Primary antibodies to stem cell antigens
  • Bead-based stem cell separation systems
  • Fluorescent-based labeling and detection
  • Stem cell protein purification and analysis tools
  • Tools for DNA and RNA-based characterization of stem cells
  • Isolation/characterization services
  • Stem cell culture media and reagents
  • Stem cell specific growth factors and cytokines
  • Tools for stem cell gene regulation
  • Stem cell services and mechanisms for in vivoand in vitro stem cell tracking
  • Expansion/differentiation services for stem cell media and RNAi
  • Stem cell lines

Key report findings include:

  • Market size determinations, with 5-year projections for the stem cell research products market (2016-2020)
  • Year-over-year analysis of stem cell grant rates, patent rates, clinical trial rates, and scientific publication rates
  • Stem cell funding sources, trends, and amounts (domestic and international)
  • Stem cell research applications, including priorities by segment
  • Relative demand for stem cell products, by stem cell type
  • Breakdown of stem cell product categories
  • Competitive analysis of leading stem cell research product companies
  • Online trends for stem cells, including Google Trends and Google Adwords
  • Social analytics for stem cells, including activity on Twitter, LinkedIn, Facebook, and more
  • Communications strategies for accessing the marketplace
  • End-user survey of stem cell scientists

End-User Survey of 289 Stem Cell Scientists

A distinctive feature of this report is an end-user survey of 289 researchers worldwide that identify as having stem cells as their research focus. These survey findings reveal researcher needs, technical preferences, key factors influencing buying decisions, and more.

The findings can be used to make effective product development decisions, create targeted marketing messages, and produce higher prospect-to-client conversion rates.

Claim this report to acquire an understanding of stem cell market trends, efficiently target emerging opportunities, and accurately identify the current and future needs of your client base.

Input Sources

The content and statistics contained in this report were compiled using a broad range of sources. These input sources include:

  • Stem Cell Grant Funding Database (RePORT Database, CIRM, MRC, Wellcome Trust - UK)
  • Stem Cell Patent Database (United States Patent and Trade Office, World Intellectual Property Organization)
  • Stem Cell Clinical Trial Database (, International Clinical Trials Registry Platform, European Union Clinical Trials Register )
  • Stem Cell Scientific Publication Database (PubMed, Highwire Press, Google Scholar)
  • Stem Cell Product Launch Announcements (Trade Journals, Google News)
  • Stem Cell Industry Events (Google News, Google Alerts)
  • Stem Cell Company News (SEC Filings, Investor Publications, Historic Performance)
  • Social Analytics Platforms (Google Trends, Google Adwords, BuzzSumo,
  • International Surveys (Electronically Distributed End-User Survey)
  • And More

Table of Contents

I. Abstract

II. Purpose

  • A. Survey Recent Stem Cell Research Product Advancements
  • B. Provide a “Snapshot” of the Global Stem Cell Research Products Market
  • C. Assess Opportunities for Commercialization
  • D. Identify Major Market Players and Assess the Competitive Environment
  • E. Identify Existing and Emerging Trends
  • F. Identify Critical Opportunities and Threats within the Marketplace

III. Research Methodology

  • A. Input Sources
  • B. Research & Analysis Methodologies
  • C. Criteria for Identifying Market Leaders
    • 1. Size of Company
    • 2. Type of Product/Services
    • 3. Degree of Specialization
    • 4. Patent Positions
    • 5. Business Reputation
    • 6. Financial Strength
    • 7. Partnerships
    • 8. Certifications

IV. Key Events In The Development Of Stem Cell Research Products

V. Types Of Stem Cells

  • A. Human Embryonic Stem Cells (hESC)
    • 1. Early, 5-7 days (Totipotent)
    • 2. Gonadal Ridge, 6 months (Pluripotent)
  • B. Fetal Stem Cells (Pluripotent)
  • C. Umbilical Cord Stem Cells (Multipotent)
    • 1. Cord Blood
    • 2. Cord Matrix (“Wharton's Jelly”)
  • D. Adult Stem Cells (multipotent)
    • 1. Hematopoietic Stem Cells
    • 2. Mesenchymal Stem Cells
    • 3. Neural Stem Cells
    • 4. Dental Stem Cells
    • 5. Adipose-Derived Stem Cells
  • E. Cancer Stem Cells (Multipotent)
  • F. Induced Pluripotent Stem Cells (iPSCs)

VI. Stem Cell Research Applications

  • A. Basic Research
  • B. Regenerative Medicine (Cell-Based Therapies)
    • 1. Diabetes Mellitus
    • 2. Cardiovascular Disease
    • 3. Neurological Disease
    • 4. Autoimmune Disease
    • 5. Hematopoietic Transplantation Research
    • 6. Orthopedic Repair
    • 7. Cancer Research
    • 8. Birth Defect Research
  • C. Drug Discovery & Development
    • 1. Assays to Aid Early Stage Discovery
    • 2. Improved Prediction of Human Responses
    • 3. Drug Development with Humanized Mouse Models
    • 4. Genetically-Engineered Stem Cell Lines for Screening
    • 5. Pluripotent Stem Cell Lines for Target Validation and Drug Screening
    • 6. Summary - Use of Stem Cells within Drug Discovery & Development

VII. Key Competitors In The Stem Cell Research Products Marketplace

  • A. Thermo Fisher Scientific (Includes Life Technologies, Invitrogen, and Other Major Brands)
    • 1. Acquisitions
    • 2. Collaborations
      • a. Invitrogen and Cellartis AB
      • b. Invitrogen and Novocell
      • c. Invitrogen and the Buck Institute
      • d. Life Technologies and Cellular Dynamics International (CDI)
      • e. Life Technologies and iPS Academia Japan
      • f. Life Technologies and Harvard University
      • g. Life Technologies and DNAVEC Corporation
      • h. ToolGen, Inc. and Thermo Fisher Scientific Sign License Agreement for CRISPR/Cas9 Genome Editing Technology
      • i. SYGNIS grants non-exclusive license on Double Switch Technology to Thermo Fisher Scientific
  • B. BD Biosciences (Division of Becton, Dickinson and Company)
    • 1. Acquisitions
    • 2. Collaborations
      • a. BD Biosciences and STEMCELL Technologies Sign License Agreements with WARF
      • b. Other Licensing Deals
  • C. Merck KGaA
    • 1. Acquisitions
      • a. Acquisition of Sigma Aldrich for $17 Billion
      • b. Other Acquisitions
    • 2. Collaborations
  • D. Miltenyi Biotec
    • 1. Acquisitions
    • 2. Collaborations
  • E. STEMCELL Technologies
    • 1. Acquisitions
    • 2. Collaborations

VIII. Stem Cell Product Areas

  • A. Stem Cell Product Categories, by Type
    • 1. Primary Antibodies
    • 2. Bead-based Cell Separations Systems
    • 3. Fluorescent-based Labeling and Detection
    • 4. Protein Purification and Analysis Tools
      • a. Protein Purification
      • b. Stem Cell Protein Analysis
      • c. Quantitative Proteomics
    • 5. DNA/RNA Based Characterization
      • a. Tools for DNA- and RNA-based Characterization
      • b. Stem Cell HLA Typing
      • c. Stem Cell Nucleic Acid Extraction and Purification, and Associated PCR/qRT-PCR Reagents
    • 6. Isolation / Characterization Services
      • a. Stem Cell HLA Typing Services
      • b. Stem Cell Custom Services
      • c. Stem Cell Custom Antibodies
    • 7. Stem Cell Culture Media and Reagents
    • 8. Growth Factors and Cytokines
    • 9. Stem Cell Gene Regulation
    • 10. In vivo / In vitro Stem Cell Tracking
    • 11. Expansion & Differentiation Services
      • a. Stem Cell Media Services
      • b. RNAi Services
    • 12. Stem Cell Lines

IX. Emerging Areas Of Stem Cell Research

  • A. Induced Pluripotent Stem Cells (iPSCs)
  • B. Cord Blood Stem Cells
  • C. Dental Pulp Stem Cells
  • D. Adipose-Derived Stem Cell Storage

X. Market Size

  • A. Definitions
  • B. Methodology
    • 1. Roll-up all competitor sales (“Gold Standard”)
    • 2. Use a weighted analysis of industry leaders (“Silver Standard”)
    • 3. Survey customers for how much they spend in the market (“Bronze Standard”)
  • C. Market Size Estimations
  • D. Five-Year Market Size Projections (2016-2020)

XI. Market Trend Analysis

  • A. Clinical Trial Analysis
    • 1. Clinical Trial Analysis, by Year
    • 2. Clinical Trial Data, by Region
    • 3. Clinical Trial Analysis, by Stem Cell Type
  • B. Grant Analysis
  • C. Patent Analysis
    • 1. Stem Cell Patents, by Year
    • 2. Stem Cell Patents, by Type
  • D. Scientific Publication Rate Analysis
    • 1. Historical Data
    • 2. Future 5-Year Projections
    • 3. Comparison of Stem Cell Research Frequency, by Cell Type
    • 4. Percentage of Stem Cell Research, by Cell Type (Trailing 12-Months)
  • E. Funding of Stem Cell Initiatives
    • 1. National Institute of Health (NIH) Funding of Stem Cells
    • 2. State Stem Cell Funding
    • 3. Private Stem Cell Funding

XII. Scientist Panel: Detailed End-User Survey

  • A. Survey Overview
  • B. Characterization of Market Survey Respondents
    • 1. Geographic Distribution of Respondents
    • 2. Respondent Breakdown by Industry Affiliation
    • 3. Breakdown of Respondents by Duration of Stem Cell Research Activity
  • C. Survey Findings - General Scope
  • D. Survey Findings - Applied Stem Cell Research
  • E. Survey Findings - Comparison of Providers (Brand Preferences)
  • F. Survey Conclusions and Analysis

XIII. Strategies For Accessing The Marketplace

  • A. Top Research Institutions Performing Stem Cell Research
    • 1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
    • 2. U.S. National Institutes of Health (NIH)
    • 3. California Institute for Regenerative Medicine
    • 4. RIKEN Center
    • 5. Kyoto University
  • B. Top Countries for Stem Cell Research
  • C. Events of Interest

XIV. Social Analytics For Stem Cells

  • A. Marketing Cost Analysis for Stem Cells - Pay-Per-Click (PPC) Analysis
  • B. Stem Cell Articles Receiving Most Social Media Shares over Past 12 Months
  • C. Google Trend Data for Stem Cells
    • 1. Google Trend Data - Mesenchymal Stem Cells
    • 2. Google Trend Data - All Types of Stem Cells
  • D. Twitter Hashtag Data
  • E. Top Five Stem Cell Influencers on Twitter

XV. Conclusions


  • APPENDIX A. Top 10 Influencers for Stem Cells


  • Table 1. Use of Stem Cells within Drug Development and Discovery
  • Table 2. Stem Cell Product Categories, by Type
  • Table 3. Number of Matrigel™ Publications Per Year
  • Table 4. Companies Offering Dental Stem Cell Storage
  • Table 5. Companies Offering Adipose-Derived Storage
  • Table 6. Revenue Estimations by Market Segment (Full-Year 2015)
  • Table 7: Size of the Stem Cell Research Products Market, 5-Year Projections
  • Table 8. Number of Stem Clinical Trials, by Year
  • Table 9: Patent Analysis, by Stem Cell Type (Title Search Only, All Results to Date)
  • Table 10: RePORT Analysis of Grant Rates per Year (Historical 10-Year Analysis)
  • Table 11: Analysis of Patent Rates per Year (Historical 10-Year Analysis)
  • Table 12: Patent Analysis, by Stem Cell Type (Title Search Only)
  • Table 13: Stem Cell Scientific Publications, by Year
  • Table 14. Comparison of Stem Cell Publication Rates, by Stem Cell Type (5-Year Historical)
  • Table 15: Percentage of Scientific Publication, By Stem Cell Type
  • Table 16. Stem Cell Funding by Year Provided by the U.S. National Institutes of Health
  • Table 17 . U.S. States Supporting Stem Cell Research
  • Table 18: State Government Support for Stem Cell Research ($ millions)
  • Table 19. Private Donor Support for Stem Cell Research
  • Table 20. Stem Cell Conferences and Events
  • Table 21: Google Adwords Price-Per-Click for All Stem Cells” Terms
  • Table 22: Google Adwords Price-Per-Click for Singular “Stem Cells” Terms
  • Table 23: Google Adwords Price-Per-Click for Plural “Stem Cells” Terms
  • Table 24: Most Shared Stem Cell Articles of the Past 12 Months (All Stem Cell Types)
  • Table 25: Google Trend Data Showing Related Searches for “Stem Cells”
  • Table 26: Rates of Twitter Usage by Country
  • Table 27: Top 10 Hashtags Related to the Term “#StemCells” on Twitter
  • Table 28: Top 5 Stem Cell Influencers on Twitter


  • Figure 1. Use of Stem Cells within Drug Development and Discovery
  • Figure 2. Number of Matrigel™ Publications Per Year
  • Figure 3. Number of iPSC Clinical Trials, by Year
  • Figure 4. Number of iPSC Grants, by Year
  • Figure 5. Number of iPSC Scientific Publications, by Year
  • Figure 6. Comparison of Umbilical Cord Blood vs. Umbilical Cord Tissue
  • Figure 7. Number of Clinical Trials with “Cord Blood” in Description
  • Figure 8. Number of Grants Contraining “Cord Blood”
  • Figure 9. Analysis of Scientific Publications Containing “Cord Blood”
  • Figure 10. Breakdown of the Global Stem Cell Research Products Market, by Segment
  • Figure 11. Size of the Stem Cell Research Products Market, by Year
  • Figure 12. Number of Stem Clinical Trials, by Year
  • Figure 13. Stem Cell Clinical Trials, by Region of the World (All Time)
  • Figure 14: Patent Analysis, by Stem Cell Type
  • Figure 15: RePORT Analysis of Grant Rates per Year (Historical 10-Year Analysis)
  • Figure 16: Number of Stem Cell Patents per Year (Historical 10-Year Analysis)
  • Figure 17: Number of Stem Cell Patents per Year, 5-Year Projections (2016-2020)
  • Figure 18: Patent Analysis, by Stem Cell Type (Title Search Only)
  • Figure 19: Stem Cell Scientific Publications, by Year
  • Figure 20: Stem Cell Scientific Publications, by Year - 5-Year Projections (2016=2020)
  • Figure 21. Year-over-Year Comparison of Stem Cell Publication Rates, by Stem Cell Type
  • Figure 22: Percentage of Scientific Publication, By Stem Cell Type
  • Figure 23: Google Adwords Price-Per-Click for Term “Stem Cells” (Plural Version)
  • Figure 24: Google Adwords Price-Per-Click for Term “Stem Cell” (Singular Version)
  • Figure 25: Comparison of Google Trend Data for “Mesenchymal Stem Cell” vs. “Mesenchymal Stem Cells over a 10-Year History
  • Figure 26: Google Trend Data for “Stem Cells” over a 10-Year History
  • Figure 27: Google Trend Data for All Types of Stem Cells over a 5-Year History Source: Google
  • Figure 28: Google Trend Data Showing Regional Interest in Stem Cells over a 5-Year History
  • Figure 29: Google Trend Data Showing City-by-City Interest in “Stem Cells” over a 5-Year History
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