實施幹細胞研究的主要研究機關
- University of Wisconsin, including WARF, WiCell, and the WISC Bank
- Johns Hopkins University
- US National Institutes of Health (NIH)
- California Institute for Regenerative Medicine

第11章結論

With recent advances in induced pluripotent stem cells (iPSC) creating excitement in stem cell research circles and U.S. President Obama expanding the number of human embryonic stem cell lines (hESC) available for federally funded research, rapid changes have been occurring in the field of stem cell science. Not surprisingly, analysis of stem cell publication rates, grant activity, patent applications, and new product launches reveal that stem cell research products have now become the single most valuable product opportunity available to life science suppliers.

The market report "Stem Cell Research Products: Opportunities, Tools & Technologieswas produced using a detailed end-user survey of research scientists, in which over 400 stem cell researchers from the U.S., Canada, Europe, Asia, Australia and other international regions participated. The findings represent perspectives across a global audience of researchers.

As a technology company, BioInformant also used proprietary data-derivation techniques to quantify and assess critical trends in the stem cells marketplace. The result is a high value, full-content report designed to inform the decision-making of research supply companies.

Featured elements of this report include:

What are novel stem cells research products that can be developed?
What stem cells types are most frequently used by research scientists?
Which species of stem cells do scientists prefer and what are the factors driving this preference (access, pricing, funding, handling advantages)?
What are the most frequently used stem cell markers?
What are the most common research applications, and how do they differ by segment (academic, industrial, and government)?
Who are the leading suppliers of stem cell products?
What stem cell product categories are already available in the marketplace?
What are current grant, patent, and scientific publication rate trends?
What are the major funding sources, trends, and dollar values, for domestic and international researchers?
What is the size of the stem cell research products marketplace and how fast is it growing?
What are communication strategies for accessing the marketplace?
And much more...

In summary, the report provides detailed insight into the stem cells research products marketplace and the needs of active stem cell scientists.

I. Abstract

II. Background: Types of Stem Cells

A. Human Embryonic Stem Cells (hESCs)
- 1. Early, 5-7 days (totipotent)
- 2. Gonadal Ridge, 6 months (multipotent)

B. Fetal Stem Cells (pluripotent)

C. Umbilical Cord Stem Cells (multipotent)
- 1. Cord Blood
- 2. Cord Matrix / “Wharton's Jelly”

D. Dental Stem Cells (multipotent)

E. Adult Stem Cells (multipotent)
- 1. Hematopoietic Stem Cells
- 2. Mesenchymal Stem Cells
- 3. Neuronal Stem Cells

F. Cancer Stem Cells (multipotent)
G. Induced Pluripotent Stem Cells (iPSCs)

H. Novel Stem Cell Types
- 1. Neural Rosette Cells (R-NSCs)
- 2. Very Small Embryonic Like (VSEL) Stem Cells

III. Stem Cell Research Applications

A. Regenerative medicine (“Cell-Based Therapies”)
- 1. Diabetes Mellitus
- 2. Cardiovascular Disease
- 3. Neurological Disease
- 4. Autoimmune Disease
- 5. Hematopoietic Disease and Transplantation Research
- 6. Orthopedic Repair
- 7. Cancer Research
- 8. Birth Defect Research

B. Non-Cell Based Applications
- 1. Assays to Aid Early Stage Discovery
- 2. Improved Prediction of Human Responses
- 3. Drug Development with Humanized Mouse Models
- 4. Genetically-Engineered Stem Cell Lines for Screening
- 5. Pluripotent Stem Cell Lines for Target Validation and Drug Screening

C. Birth Defect Research

IV. Key Market Competitors: Providers of Diverse Stem Cell Product Lines

A. Invitrogen Corporation
- 1. Stem Cell Products
  - a. Isolation and Characterization Products
  - b. Expansion and Differentiation Products
- 2. Collaborations
  - a. Invitrogen and Cellartis AB
  - b. Invitrogen and Novocell
  - c. Invitrogen and the Buck Institute

B. BD Biosciences
- 1. Stem Cell Products
  - a. Isolation
  - b. Culturing
  - c. Analysis
- 2. Collaborations: BD Biosciences and Stem Cell Technologies

C. Comparison of Stem Cell Publication Rates: Invitrogen vs. BD Biosciences

V. Product Areas

A. Primary Antibodies
B. Bead-based Cell Separations Systems
C. Fluorescent-based Labeling and Detection

D. Protein Purification & Analysis Tools
- 1. Protein Purification
- 2. Stem Cell Protein Analysis
- 3. Quantitative Proteomics

E. DNA/RNA Based Characterization
- 1. Tools for DNA & RNA Based Characterization
- 2. Stem Cell HLA Typing
- 3. Stem Cell Nucleic Acid Extraction and Purification, & Associated PCR/RT-PCRReagents

F. Isolation / Characterization Services
- 1. Stem Cell HLA Typing Services
- 2. Stem Cell Custom Services
- 3. Stem Cell Custom Antibodies

G. Stem Cell Culture Media & Reagents
H. Growth Factors & Cytokines
I. Stem Cell Gene Regulation
J. In vivo / In vitro Cell Tracking
K. Expansion / Differentiation Services
L. Stem Cell Lines

VI. Market Size

A. Definition of “Stem Cell Research Products”
B. Experimental Approach
C. Stem Cell Research Products, Market Size (in Millions)
D. Stem Cell Antibodies, Market Size (in Millions)
E. Stem Cell Therapies, Market Size (in Billions)

VII. Current Market Assessment

A. Breakdown of Research Segments by End-user Application
- 1. Basic Research
- 2. Applied Research
  - a. Autologous and Allogeneic Cell Therapy
  - b. Toxicology Screening for Drug Discovery and Development

B. Breakdown of Stem Cell Research by Cell Type
- 1. Cord Blood Stem Cells
- 2. Dental Stem Cells
- 3. iPSCs

C. Breakdown of Stem Cell Research by Species

D. Publication Rate Analysis
- 1. Overview of Stem Cell Publication Rates
- 2. Comparative Analysis of Stem Cell Publication Trends

E. Sources of Stem Cell Funding
- 1. Federal
- 2. State
- 3. Private

F. Patent Analysis

G. Geographical Analysis: Domestic vs. International Status

VIII. MARKET TRENDS: DETAILED END-USER SURVEY (SCIENTIST PANEL)

A. Survey Overview

B. Characterization of Market Survey Respondents
- 1. Geographic Distribution of Respondents
- 2. Respondent Breakdown by Industry Affiliation
- 3. Breakdown of Respondents by Duration of Stem Cell Activity

C. Survey Findings
- 1. Breakdown of Stem Cell Research Activity by Cell Type
- 2. Dominant Stem Cell Markers
- 3. Market Penetration of Stem Cell Markers by Cell Type
  - a. Human Embryonic Stem Cell (hESCs)
  - b. Mesenchymal Stem Cell (MSCs)
  - c. Neural Stem Cells (NSCs)
  - d. Hematopoietic Stem Cells (HSCs)

D. Preferred Providers of Stem Cell Antibodies

IX. MARKET FORECASTS

A. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery
B. Short-term (3-5yrs): Therapies Involving Cord Blood and Adult Stem Cells
C. Long-Term (10yrs): Therapies involving hESCs

X. STRATEGIES FOR ACCESSING THE MARKETPLACE

A. Top Research Institutions Performing Stem Cell Research
- 1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
- 2. Johns Hopkins University
- 3. US National Institutes of Health (NIH)
- 4. California Institute for Regenerative Medicine

B. Events of Interest

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幹細胞研究產品：機會、工具以及技術

Stem Cell Research Products - Opportunities, Tools, and Technologies