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市場調查報告書

癌症治療藥開發平台的微型核糖核酸(miRNA)

MicroRNAs in Cancer Drug Pipeline Update

出版商 BioSeeker Group AB 商品編碼 296717
出版日期 內容資訊 英文
商品交期: 最快1-2個工作天內
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癌症治療藥開發平台的微型核糖核酸(miRNA) MicroRNAs in Cancer Drug Pipeline Update
出版日期: 2016年08月04日 內容資訊: 英文
簡介

本報告提供臨床實驗開發平台上的癌症治療用微型核糖核酸(miRNA)的開發情形調查、開發經營者與其合作夥伴、各藥物臨床實驗進展、標的種類彙總與其分子功能、標的定位、表達譜、關聯的適應症等和的內容,為您概述為以下內容。

藥物開發平台的更新

研究開發企業、機關(全373家及其合作夥伴)

藥物的名稱和別名

藥物研發的階段(553種微型核糖核酸(miRNA)和2,050件藥物研發企劃)

  • 各開發平台階段的醫藥品數量
    • 已上市:44件
    • 登記前:5件
    • 第三階段:60件
    • 第二階段:195件
    • 第一階段:246件
    • 前臨床:274件
    • 沒有資料:2件
    • 中斷:6件
    • 中止:270件

適應症

標的

  • 突然變異
  • 生物學的結構

標的表達譜

  • 正常組織(48種)
  • 癌症(20種)
  • 細胞株(47種)
  • 初代血球(12個樣品)

機制

化合物

藥物簡介

開發經營者和合作夥伴

標的與其分子功能

標的位置確認

突然變異

目標途徑

藥物的機制

藥物開發企劃

藥物的說明

化合物資料

專利資料

登記、認證

第IV相資料

第三階段資料

第二階段資料

第一階段資料

第0相資料

全臨床資料

藥物研發資料

應用的特徵

動態報告作成功能

系統必要條件

  • OS:Windows (2000/XP/Vista/7/8),Mac用戶只線上利用可能
  • 瀏覽器應用(Internet Explorer,Firefox, Chrome, Safari)
  • 上網服務(相關網際網路、資源的點閱存取)

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目錄
Product Code: BSG18113

The hot entry of microRNA (miRNA) targeting drugs in oncology may come to revolutionize how we in the near future can launch a highly tumor-specific, multi-targeted attack with minimal toxicities either as a monotherapy or perhaps even more likely in a combinatorial drug setting. miRNA may also hold great potential as biomarkers, albeit a lot of work is a head of us and the industry hasn't really caught up with the science yet in clinical trials as very few of them address the predictive capability of miRNAs.

In this Drug Pipeline Update about MicroRNAs in cancer, BioSeeker features drugs which stimulates, inhibits or regulates miRNA for the treatment of cancer, early miRNA biomarker evaluations in cancer and those drug targets which stands under control by known miRNAs. To complete the competitive landscape around miRNAs BioSeeker has also included all other competitor substances to known microRNAs targets. It is a true David versus Goliath situation and it all comes down to in which biological context targeting miRNAs is the smarter and safer choice? Consequently this product is a great tool for both those who could be facing competition from miRNAs and for miRNA developing companies to know other drugs targeting the same targets as their miRNAs.

There are today 567 companies plus partners developing 841 microRNA targeting and competitor drugs in 3023 developmental projects in cancer. In addition, there are 5 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 343 drugs. Micrornas In Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 289 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 264 out of the 266 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 56 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 567 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 841 microRNA targeting and competitor drugs in development, which have a total of 3023 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 57
  • Pre-registration# 8
  • Phase III# 90
  • Phase II# 238
  • Phase I# 312
  • Preclinical# 412
  • No Data# 29
  • Suspended# 5
  • Ceased# 343
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included microRNA targeting and competitor drugs are also in development for 275 other indications, where of 177 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 264 out of the 266 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 222 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 4551 structures available today among drug targets.
  • Identified drugs are linked to more than 289 different targets, divided into 56 classifications of molecular function:
  • Antigen binding
  • ATPase activity
  • Auxiliary transport protein activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Chromatin binding
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Cytoskeletal protein binding
  • Deacetylase activity
  • Deaminase activity
  • DNA binding
  • DNA topoisomerase activity
  • DNA-methyltransferase activity
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activity
  • Heat shock protein activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Ligase activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • Molecular function unknown
  • Motor activity
  • Oxidoreductase activity
  • Peroxidase activity
  • Protease inhibitor activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein tyrosine phosphatase activity
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Structural molecule activity
  • Superoxide dismutase activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Transferase activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 33 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Golgi apparatus
  • Golgi membrane
  • Integral to membrane
  • Intermediate filament
  • Kinetochore
  • Lysosome
  • Membrane fraction
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Sarcoplasmic reticulum
  • Secreted
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 420 protein expression profiles of 251 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 243 Pathways
  • KEGG# 185 Pathways
  • NCI-Nature# 255 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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