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市場調查報告書

癌症治療藥開發平台的罕見疾病用醫藥品

Orphan Drugs in Oncology Drug Pipeline Update

出版商 BioSeeker Group AB 商品編碼 274976
出版日期 內容資訊 英文
商品交期: 最快1-2個工作天內
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癌症治療藥開發平台的罕見疾病用醫藥品 Orphan Drugs in Oncology Drug Pipeline Update
出版日期: 2016年08月04日 內容資訊: 英文
簡介

本報告提供癌症治療藥開發平台的罕見疾病用醫藥品(孤兒藥)的開發情形個別調查分析,開發經營者及合作經營者,各開發階段的分類,標靶種類與分子功能,標靶定位,表達譜,其他的適應症等彙整資料,為您概述為以下內容。

※本商品是CD-ROM提供的資料庫應用程式。想利用的客人請先在個人電腦上安裝應用程式。

調查內容

  • 開發經營者(282間公司)·合作經營者
  • 藥物名及別名
    • 商標名
    • 學名藥
    • 代碼名稱
  • 開發現階段的分類:正在開發的罕見疾病用醫藥品361種、計2061件開發企劃
    • 已上市
    • 登記前
    • 第三階段
    • 第二階段
    • 第一階段
    • 前臨床
    • 中斷
    • 中止
  • 適應症
  • 標靶:269種標靶·64分子功能分類
    • 氨肽酶活性
    • ATPase活性
    • Auxiliary transport protein activity
    • 羧基裂解酶活性
    • 觸媒活性
    • 細胞黏合分子活性
    • Chaperone activity
    • 趨化素活性
    • 補體活性
    • Cysteine-type peptidase activity
    • 細胞激素活性
    • 去乙酰化酶活性
    • 脫氨酶活性
    • DNA結合
    • DNA修復蛋白質
    • DNA異構轉化酶活性
    • DNA依賴性DNA聚合酵素活性
    • DNA甲基轉移酶活性
    • Extracellular ligand-gated ion channel activity
    • 細胞外矩陣結構成分
    • G蛋白偶聯受體活性
    • 成長因子活性
    • GTPase活性
    • 水解酶活性
    • 異構酶活性
    • 蛋白激酶活性
    • 蛋白激酶結合
    • 蛋白激酶調節因子活性
    • 配體依賴核受體活性
    • 連接酶活性
    • 脂質蛋白激酶活性
    • 脂質磷酸酶活性
    • Metallopeptidase activity
    • MHC級I受體活性
    • 氧化還原酶活性
    • 胜肽荷爾蒙
    • 過氧化酶活性
    • 磷酸二酯水解酶的活性
    • 磷酸化酶活性
    • 蛋白質水解酵素阻礙活性
    • 蛋白質結合
    • 蛋白質絲胺酸/蘇胺酸激酶活性
    • 蛋白質蘇氨酸/蛋白酪氨酸激酶活性
    • 蛋白質酪氨酸磷酸酶的活性
    • 蛋白酪氨酸/絲胺酸/蘇氨酸磷酸酶的活性
    • 蛋白質蛋白酪氨酸激酶活性
    • 受體活性
    • 受體結合
    • RNA結合
    • RNA依賴性DNA聚合酵素活性
    • Serine-type peptidase activity
    • 細胞骨骼結構成分
    • SOD活性
    • T細胞受體活性
    • 轉錄因子活性
    • 轉錄調節因子活性
    • 轉移酵素活性
    • 轉譯調節因子活性
    • 跨膜受體活性
    • Transmembrane receptor protein tyrosine kinase activity
    • 轉運蛋白活性
    • Voltage-gated ion channel activity
  • 特定標靶細胞下的位置:25處
    • 細胞表面
    • 中心體
    • 披網格蛋白小泡
    • 細胞質
    • 細胞質小泡
    • 細胞骨骼
    • 胞質溶膠
    • 內質網
    • 核內體
    • 細胞外
    • 高爾基體
    • 溶小體
    • 微管
    • 粒線體膜
    • 粒腺體
    • 核膜
    • 核仁
    • 核周圍領域
    • 核周圍小胞
    • 質膜
    • 肌漿網
    • 分泌顆粒
    • 分泌囊泡

標靶表現簡介

  • 48種正常組織
  • 20種癌症
  • 47種細胞株
  • 12初級血細胞

途徑的詢問

機制

化合物

藥物簡介

  • 藥物名
  • 臨床實驗負責企業及合作夥伴
  • 標靶及標靶分子功能
  • 標靶部位
  • 突變
  • 生物學的結構
  • 標靶途徑
  • 機制
  • 開發企劃
  • 藥物說明
  • 化合物資料
  • 專利資料
  • 核准
  • 交易和授權
  • 第四階段資料
  • 第三階段資料
  • 第二階段資料
  • 第一階段資料
  • 第0階段資料
  • 臨床前資料
  • 藥物研發資料

Drug Pipeline Update軟體·應用程式

系統必要條件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

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目錄
Product Code: BSG18009

This is a worldwide report on cancer drugs which have now or in the past received orphan drug status. This product will give you unique access not only to those cancer indications in which drugs are being granted orphan drug status, but also detailed insights in to their mechanism of action and developmental strategy. The orphan drug designation is designed to promote the development of drugs that may provide significant benefit to patients suffering from rare, life-threatening diseases. This designation will in many countries provide several years of marketing exclusivity if the product candidate is approved for the designated orphan indication. It also provides special incentives for sponsors, including eligibility for protocol assistance and possible exemptions or reductions in certain regulatory fees during development or at the time of applying for marketing approval.

There are today 476 companies plus partners developing 665 orphan drugs in oncology drugs in 4085 developmental projects in cancer. In addition, there are 15 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 190 drugs. Orphan Drugs In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 422 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 404 out of the 407 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 79 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 476 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 665 orphan drugs in oncology drugs in development, which have a total of 4085 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 170
  • Pre-registration# 22
  • Phase III# 190
  • Phase II# 413
  • Phase I# 296
  • Preclinical# 133
  • No Data# 128
  • Suspended# 15
  • Ceased# 190
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included orphan drugs in oncology drugs are also in development for 458 other indications, where of 238 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 404 out of the 407 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 314 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 6208 structures available today among drug targets.
  • Identified drugs are linked to more than 422 different targets, divided into 79 classifications of molecular function:
  • Aminopeptidase activity
  • ATPase activity
  • Auxiliary transport protein activity
  • Carboxy-lyase activity
  • Carboxypeptidase activity
  • Caspase activator activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Chromatin binding
  • Cofactor binding
  • Complement activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Cytoskeletal protein binding
  • Deacetylase activity
  • Deaminase activity
  • DNA binding
  • DNA repair protein
  • DNA topoisomerase activity
  • DNA-directed DNA polymerase activity
  • DNA-directed RNA polymerase activity
  • DNA-methyltransferase activity
  • Extracellular ligand-gated ion channel activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Glutathione transferase activity
  • Growth factor activity
  • GTPase activity
  • Guanylate cyclase activity
  • Heat shock protein activity
  • Hydrolase activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • Methyltransferase activity
  • MHC class I receptor activity
  • Molecular function unknown
  • Motor activity
  • Oxidoreductase activity
  • Peptide hormone
  • Peroxidase activity
  • Phosphoric diester hydrolase activity
  • Phosphorylase activity
  • Protease inhibitor activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Receptor signaling protein tyrosine phosphatase activity
  • RNA binding
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • T cell receptor activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Transferase activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Voltage-gated ion channel activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 32 different primary and alternate sub-cellular localizations:
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Golgi apparatus
  • Integral to membrane
  • Intermediate filament
  • Kinetochore
  • Lysosome
  • Membrane fraction
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Sarcoplasmic reticulum
  • Secreted
  • Secretory granule
  • Secretory vesicle
  • Soluble fraction
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 597 protein expression profiles of 379 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 257 Pathways
  • KEGG# 214 Pathways
  • NCI-Nature# 253 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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