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市場調查報告書

癌症治療藥開發平台的黏合結合標的

Adherens Junction Targeting in Oncology Drug Pipeline Update

出版商 BioSeeker Group AB 商品編碼 263209
出版日期 內容資訊 英文
商品交期: 最快1-2個工作天內
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癌症治療藥開發平台的黏合結合標的 Adherens Junction Targeting in Oncology Drug Pipeline Update
出版日期: 2016年08月04日 內容資訊: 英文
簡介

本報告提供以黏合結合標的為標的的癌症治療藥開發情形個別調查分析,提供開發經營者及合作經營者,各開發階段的分類,標的種類與分子功能,標的位置特定,發現簡介,其他的適應症等彙整資料,為您概述為以下內容。

※本商品為以CD-ROM型式提供的資料庫應用程式。若想使用,須在您的電腦上安裝應用程式。

調查內容

  • 開發經營者(154公司)•合作經營者
  • 藥物名及別名
    • 商標名
    • 學名藥
    • 代碼名稱
  • 現開發階段的分類:正在開發的黏合結合標靶藥物189種、計714件開發企劃
    • 已上市
    • 登記前
    • 第三階段
    • 第二階段
    • 第一階段
    • 前臨床
    • 沒有數據
    • 中斷
    • 中止
  • 適應症
  • 標的:91種標的•23分子功能分類
    • 細胞黏合分子活性
    • 保護者活性
    • 染色質結合
    • DNA結合
    • 成長因子活性
    • GTP酶活性
    • 蛋白激酶活性
    • 脂質蛋白激酶活性
    • 過氧化酶活性
    • 蛋白質結合
    • 蛋白質絲胺酸/蘇氨酸激酶活性
    • 蛋白質酪氨酸去磷酸酶活性
    • 蛋白質蛋白酪氨酸激酶活性
    • 受體活性
    • 受體信號傳達蛋白質絲胺酸/蘇氨酸激酶活性
    • 受體信號傳達蛋白質蛋白酪氨酸激酶活性
    • 細胞骨骼結構成分
    • 轉錄因子活性
    • 轉錄調節因子活性
    • 轉譯調節因子活性
    • 跨膜受體蛋白質蛋白酪氨酸激酶活性
    • 轉運子活性等
  • 特定標的細胞下的位置:21處
    • 側膜
    • 細胞間結合
    • 中心體
    • 染色體
    • 披網格蛋白囊泡
    • 細胞質
    • 細胞質囊泡
    • 細胞骨骼
    • 網站膠體溶液
    • 內質網
    • 核內體
    • 細胞外
    • 細胞外矩陣
    • 粒腺體
    • 核仁
    • 核周圍領域
    • 核周圍囊泡
    • 質膜
    • 分泌
    • 囊泡

標的表現簡介

  • 48種正常組織
  • 20種癌症
  • 47種細胞株
  • primary blood cells的12樣品

途徑的詢問

機制

化合物

藥物簡介

  • 藥物名
  • 臨床實驗主治醫師師及合作夥伴
  • 標的及標的分子功能
  • 標的部位
  • 標的途徑
  • 機制
  • 開發企劃
  • 藥物說明
  • 化合物資料
  • 專利資料
  • 分析
  • 第三階段資料
  • 第二階段資料
  • 第一階段資料
  • 臨床前資料
  • 授權資訊

關於Drug Pipeline Update軟體•應用程式

系統必要條件

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)

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目錄
Product Code: BSG17678

Cell-cell adherens junctions, the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation.

There are today 277 companies plus partners developing 357 targeting adherens junctions drugs in 1199 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated number of ceased drugs over the last years amount to another 136 drugs. Adherens Junction Targeting In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 134 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 132 out of the 132 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 35 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 277 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 357 targeting adherens junctions drugs in development, which have a total of 1199 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 25
  • Pre-registration# 5
  • Phase III# 38
  • Phase II# 103
  • Phase I# 141
  • Preclinical# 171
  • No Data# 10
  • Suspended# 1
  • Ceased# 136
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included targeting adherens junctions drugs are also in development for 145 other indications, where of 128 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 132 out of the 132 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 115 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 2259 structures available today among drug targets.
  • Identified drugs are linked to more than 134 different targets, divided into 35 classifications of molecular function:
  • Antigen binding
  • Auxiliary transport protein activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chromatin binding
  • Cytokine activity
  • DNA binding
  • DNA topoisomerase activity
  • Growth factor activity
  • GTPase activity
  • Isomerase activity
  • Kinase activity
  • Lipid kinase activity
  • Molecular function unknown
  • Peroxidase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Receptor signaling protein tyrosine phosphatase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 26 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Golgi apparatus
  • Integral to membrane
  • Kinetochore
  • Lysosome
  • Mitochondrion
  • Nucleolus
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Secreted
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 213 protein expression profiles of 127 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 189 Pathways
  • KEGG# 151 Pathways
  • NCI-Nature# 240 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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