Abstract
Executive Summary
BioSeeker Group have identified 155 companies plus partners who are today
developing 165 Notch pathway targeting drugs in 494 developmental projects in
cancer across 120 different targets. In addition, there are 2 suspended drugs
and another 102 drugs where development has been ceased.
For busy executives within Pharma, Biotech and Investment companies who know
they need to stay on top of the developmental environment in their field, we
offer the Drug Pipeline update series.
You get detailed, world-wide drug pipeline information, delivered in an
unbiased and independent pipeline progress analysis for each identified drug.
Buying the Notch Signaling Pathway in Oncology Drug Pipeline Update 2012 will
mean you have this important data at your fingertips and ensure that you can:
- Show investors/board/management that you are right on top of drug
development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc. and track
them by their products.
- Jump start competitive drug intelligence operations
- Benchmark your own development against world wide data
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/outlicensing strategy work
Some facts about Notch Signaling Pathway in Oncology Drug Pipeline Update 2012
Aberrant Notch signaling has been linked to a number of malignancies including
leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and
kidneys. There are today 155 companies plus partners developing 165 Notch
pathway targeting drugs in 494 developmental projects in cancer. In addition,
there are 2 suspended drugs and the accumulated number of ceased drugs over
the last years amount to another 102 drugs. Notch Signaling Pathway In
Oncology Drug Pipeline Update lists all drugs and gives you a progress
analysis on each one of them. Identified drugs are linked to 120 different
targets. These targets are further categorized on in the software application
by 33 classifications of molecular function and with pathway referrals to
BioCarta, KEGG and NetPath.
Table of Contents
This short overview shows actual findings from the Notch Signaling Pathway in
Oncology Drug Pipeline Update 2012 report.
Investigators
Includes more than 155 principal investigators plus their collaborators. There
is direct access from inside the application to web pages of all principal
investigators.
Note: You are able to sort and find drugs according to investigators
and partners from drop-down menus in the application. You may also sort and
find drugs according to country of investigator.
Drug name & Synonyms
Lists commercial, generic and code names for drugs.
Developmental stage
This Drug Pipeline Update contains 165 Notch pathway targeting drugs in
development, which have a total of 494 developmental projects in cancer. In
addition there are suspended and ceased drugs.
Pipeline Breakdown According to Number of Drugs:
- Marketed# 14
- Registered# 1
- Pre-registration# 1
- Phase III# 8
- Phase II# 44
- Phase I# 54
- Preclinical# 101
- No Data# 3
- Suspended# 2
- Ceased# 102
Note: You are able to sort and find drugs according to developmental
stage from drop-down menu in the application.
Indications
Included Notch pathway targeting drugs are also in development for 118 other
indications, where of 68 are different cancer indications.
Note: You are able to find and sort drugs according to type of
indication from drop-down menu in the application.
Targets
Identified drugs are linked to more than 120 different targets, divided into
33 classifications of molecular function:
- ATPase activity
- Catalytic activity
- Cell adhesion molecule activity
- Cysteine-type peptidase activity
- Cytokine activity
- Cytoskeletal protein binding
- DNA binding
- DNA repair protein
- DNA topoisomerase activity
- G-protein coupled receptor activity
- GTPase activity
- Kinase activity
- Kinase binding
- Kinase regulator activity
- Ligand-dependent nuclear receptor activity
- Lipid kinase activity
- Metallopeptidase activity
- Molecular function unknown
- Oxidoreductase activity
- Protein binding
- Protein serine/threonine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling complex scaffold activity
- Receptor signaling protein serine/threonine kinase activity
- Structural constituent of cytoskeleton
- Transcription factor activity
- Transcription regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
- Ubiquitin-specific protease activity
Identified targets are categorized into 21 different primary and alternate
sub-cellular localizations:
- Centrosome
- Chromosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoplasmic vesicle
- Cytoskeleton
- Cytosol
- Endoplasmic reticulum
- Endosome
- Extracellular
- Golgi apparatus
- Integral to membrane
- Mitochondrial membrane
- Mitochondrion
- Nuclear membrane
- Nucleolus
- Nucleus
- Perinuclear region
- Perinuclear vesicle
- Plasma membrane
- Secreted
Note: You are able to find and sort drugs according to target gene
name, molecular function of target, and target localization from drop-down
menus in the application.
Target Expression Profile
Direct links are provided from inside the application to 182 protein
expression profiles of 107 drug targets in various human tissues and cancer
types, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referals
Identified targets have been cross referenced against their involvement in
different cellular pathways, according to BioCarta, KEGG and NetPath.
- BioCarta# 210 Pathways
- KEGG# 128 Pathways
- NetPath# 25 Signaling Pathways
Note: You are able to find and sort drugs according to targeted
pathways from drop-down menus in the application.
Mechanism
In total there are different drug mechanism of action represented in this Drug
Pipeline Update.
Note: You are able to find and sort drugs according to mechanism of
action from drop-down menu in the application.
Compound
Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type
from drop-down menu in the application.
The Drug Profiles: Progress analysis and review of drug development.
Notch Signaling Pathway in Oncology Drug Pipeline Update 2012 provides you
with a profile for each identified drug. A typical drug profile reports on,
depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms.
Principal Investigator & Partners
Presentation of principal investigator and partners.
Target and Molecular Function of Target
Described target(s) is/are presented with:
- Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] -
Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues,
cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways
according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication,
developmental stage and status.
Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight.
Patent Data
Available patent information related to the drug is presented here.
Analysis
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific
data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific
data.
Licensing Information
Availability for licensing.
About the unique Drug Pipeline Update Software Application
After purchase, the Drug Pipeline Update is delivered to you via electronic
download in a powerful yet easy to use desktop application which requires no
installation.
Find and sort drugs by twelve different parameters plus free text search
field. Our dynamic report generator lets you easily and quickly generate HTML
drug profile reports directly in your web browser, whether it is a single drug
profile or your own report selection of drugs that match your criteria.
Application Features
Use 13 different parameters, available in drop-down menus, to find and sort
among drugs:
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas,
KEGG, and NetPath
- Direct links to company web pages of principal investigators
Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html
reports directly in your web browser (Internet Explorer), whether it is a
single drug profile or an entire search you want have a report of.
System Requirements
- Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow
Leopard) and OS X 10.7 (Lion)
- Browser Application (Internet Explorer)
- Internet access (to access related internet resources)
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