Cover Image
市場調查報告書

癌症治療藥物產品線之B細胞受體信號路徑最新趨勢:2011年

B Cell Receptor Signaling Pathway in Oncology Drug Pipeline Update

出版商 BioSeeker Group AB 商品編碼 167162
出版日期 內容資訊 英文
商品交期: 最快1-2個工作天內
價格
Back to Top
癌症治療藥物產品線之B細胞受體信號路徑最新趨勢:2011年 B Cell Receptor Signaling Pathway in Oncology Drug Pipeline Update
出版日期: 2016年08月04日 內容資訊: 英文
簡介

現今有145間企業及合作夥伴從事540種癌症相關開發計畫中,190件為以B細胞受體路徑為目標之藥劑開發。目前為止被中止藥劑已累積66件以上。

本報告為,個別分析開發中藥劑,並以標靶、開發階段分類,匯整其機轉、適應等藥劑簡介,以下列摘要形式闡述。

臨床實驗擔任醫師

藥劑名稱及別名

  • 商標名
  • 非專利藥物
  • 代號

開發階段

  • 540種開發計畫中190種藥劑最新趨勢
    • 已上市
    • 註冊前
    • 第3相
    • 第2相
    • 第1相
    • 臨床前
    • 無數據
    • 中斷
    • 中止

適應

標靶

  • 120種標靶以36種分類

標靶發現簡介

路徑

機轉

化合物

藥劑簡介

  • 藥劑名
  • 臨床實驗擔任醫師及合作夥伴
  • 標靶及標靶分子功能
  • 標靶部分
  • 標靶路徑
  • 機轉
  • 開發計畫
  • 藥劑解說
  • 化合物數據
  • 專利數據
  • 商業及市場
  • 第3相數據
  • 第2相數據
  • 第1相數據
  • 臨床實驗前數據
  • 授權資訊

應用特性

系統要件

  • AMD-Athlon/Pentium II PC
  • Windows 98/NT4/2000/ME/XP/VISTA/Windows 7
  • 8x-speed CD Rom drive
  • SVGA 16 bit display. (32 bit recommended)
  • 32 MB of available RAM (128 MB recommended)
  • Browser Application (Internet Explorer, Firefox)
  • Internet access (for related internet resources)

本網頁內容可能與最新版本有所差異。詳細情況請與我們聯繫。

目錄
Product Code: BSG7587

Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules.

There are today 309 companies plus partners developing 424 B cell receptor pathway targeting drugs in 1700 developmental projects in cancer. In addition, there are 5 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 154 drugs. B Cell Receptor Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 198 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 194 out of the 195 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 43 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 309 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 424 B cell receptor pathway targeting drugs in development, which have a total of 1700 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 33
  • Registered# 1
  • Pre-registration# 1
  • Phase III# 40
  • Phase II# 139
  • Phase I# 181
  • Preclinical# 196
  • No Data# 21
  • Suspended# 5
  • Ceased# 154
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included B cell receptor pathway targeting drugs are also in development for 222 other indications, where of 148 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 194 out of the 195 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 162 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3664 structures available today among drug targets.
  • Identified drugs are linked to more than 198 different targets, divided into 43 classifications of molecular function:
  • ATPase activity
  • B cell receptor activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chromatin binding
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deacetylase activity
  • DNA binding
  • DNA topoisomerase activity
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activity
  • Heat shock protein activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Molecular function unknown
  • Peroxidase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • T cell receptor activity
  • T cell receptor binding
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Sub-Cellular Localization
  • Identified targets are categorized into 30 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Focal adhesion
  • Golgi apparatus
  • Kinetochore
  • Lysosome
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Secreted
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 324 protein expression profiles of 188 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 237 Pathways
  • KEGG# 162 Pathways
  • NCI-Nature# 246 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

  • Search, Find and Filter Panel with Initial Result Presentation
  • With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
  • The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
  • Direct linkage from inside the application to related internet resources
  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

  • Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
Back to Top