Abstract
Product Description
Executive Summary
Cancer immunotherapy offers an attractive therapeutic addition, delivering
treatment of high specificity, low toxicity and prolonged activity. In this
Drug Pipeline Update BioSeeker brings together the fields of antibodies,
vaccines, and immunostimulators in oncology drug development into one source.
There are today 421 (291) companies plus partners developing 824 (396) cancer
immunotherapy drugs in 1612 (674) developmental projects in cancer. In
addition, the accumulated number of ceased drugs over the last years amount to
another 329 (178) drugs. Immunotherapy In Oncology Drug Pipeline Update lists
all drugs and gives you a progress analysis on each one of them. Identified
drugs are linked to 315 (158) different targets. These targets are further
categorized on the CD-ROM by 54 (45) classifications of molecular function and
with pathway referrals to BioCarta, KEGG and NetPath. Figures in brackets are
comparative data from last year.
Find and sort drugs by twelve different parameters plus free text search
field. Our dynamic report generator lets you with ease and speed generate html
reports directly in your web browser, whether it is a single drug profile or
an entire search you want have a report of.
How May This Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug
development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click
from inside the application and you may search the World Wide Web and PubMed
for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which
requires no installation on your computer.
Table of Contents
Drug Pipeline Update at a Glance
Investigators
Includes more than 421 (291) principal investigators plus their collaborators.
There is direct access from inside the application to web pages of all
principal investigators.
Drug name & Synonyms
Lists commercial, generic and code names for drugs.
Developmental stage
This Drug Pipeline Update contains 824 (396) cancer immunotherapy drugs in
active development, which have a total of 1612 (674) developmental projects in
cancer:
- Marketed# 61 (40)
- Registered# 8 (2)
- Pre-registration# 8 (6)
- Phase III# 451 (26)
- Phase II# 357 (202)
- Phase I# 357 (145)
- Preclinical# 559 (249)
- No Data# 50 (50)
- Suspended# 21
- Discontinued# 18
In addition there are 329 (178) ceased drugs.
Targets
Identified drugs are linked to more than 315 (158) different targets, divided
into 54 (45) classifications of molecular function:
- Acid phosphatase activity
- Antigen binding
- Auxiliary transport protein activity
- B cell receptor activity
- Carboxypeptidase activity
- Catalytic activity
- Cell adhesion molecule activity
- Chaperone activity
- Chemokine activity
- Cofactor binding
- Complement activity
- Cysteine-type peptidase activity
- Cytokine activity
- Defense/immunity protein activity
- DNA binding
- DNA topoisomerase activity
- DNA-directed DNA polymerase activity
- Extracellular ligand-gated ion channel activity
- Extracellular matrix structural constituent
- G-protein coupled receptor activity
- Growth factor activity
- Hormone activity
- Hydrolase activity
- Isomerase activity
- Kinase activity
- Kinase binding
- Kinase regulator activity
- Ligand-dependent nuclear receptor activity
- Ligase activity
- Lipid kinase activity
- Metallopeptidase activity
- MHC class I receptor activity
- Molecular function unknown
- Oxidoreductase activity
- Peptidase activity
- Peptide hormone
- Protease inhibitor activity
- Protein binding
- Protein serine/threonine kinase activity
- Protein threonine/tyrosine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling complex scaffold activity
- RNA-directed DNA polymerase activity
- Serine-type peptidase activity
- T cell receptor activity
- Transcription factor activity
- Transcription regulator activity
- Translation regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
- Unclassified
Identified targets are categorized into 25 (23) different primary and
alternate sub-cellular localizations:
- Apical membrane
- Cell junction
- Cell surface
- Centrosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoplasmic vesicle
- Cytoskeleton
- Endoplasmic reticulum
- Endosome
- Extracellular
- Extracellular matrix
- Golgi apparatus
- Immunological synapse
- Integral to membrane
- Lysosome
- Mitochondrion
- Nucleolus
- Nucleus
- Perinuclear region
- Perinuclear vesicle
- Plasma membrane
- Secreted
- Secretory granule
- Soluble fraction
Target Expression Profile
Direct links are provided from inside the application to 282 (142) protein
expression profiles of 201 (96) drug targets in various human tissues and
cancer types, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referals
Identified targets have been cross referenced against their involvement in
different cellular pathways, according to BioCarta, KEGG and NetPath.
- BioCarta# 200 (169) Pathways
- KEGG# 112 (77) Pathways
- NetPath# 19 (19) Signaling Pathways
Compound
Identified drug compounds are described by:
- Compound type, Chemical name, CAS Number and molecular weight
Drug Profile
- Progress analysis and review of drug development. A typical drug profile
reports on, depending on stage of development and available information:
- Drug Name & Synonyms
- Presentation of drug name and synonyms
- Principal Investigator & Partners
- Presentation of principal investigator and partners
- Target and Molecular Function of Target
- Described target(s) is/are presented with:
- Official Gene Symbol Official Gene Name [Species/Homo Sapiens] Molecular
Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues,
cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
- Targeted Pathways
- Described target(s) is/are matched for the involvement in cellular
pathways according to BioCarta, KEGG, and NetPath.
- Mechanism
- Drug mechanism of action
- Developmental Projects
- Summary field of developmental projects for the drug, including
indication, developmental stage and status.
- Example:
- Cancer, myeloma Phase II Clinical Trial Active
- Cancer, prostate Phase III Clinical Trial Ceased
- Drug Description
- Short introduction to drug
- Compound Data
- Compound type, Chemical name, CAS Number and molecular weight
- Patent Data
- Available patent information related to the drug is presented here.
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
- Phase III Data
- Available Phase III development data, developmental history and scientific
data.
- Phase II Data
- Available Phase II development data, developmental history and scientific
data.
- Phase I Data
- Available Phase I development data, developmental history and scientific
data.
- Preclinical Data
- Available preclinical development data, developmental history and
scientific data.
- Licensing Information
- Availability for licensing
Application Features
Use 13 different parameters, available in drop-down menus, to find and sort
among drugs
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas,
KEGG, and NetPath
- Direct links to company web pages of principal investigators
Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html
reports directly in your web browser (Internet Explorer and FireFox), whether
it is a single drug profile or an entire search you want have a report of.
System Requirements
- AMD-Athlon/Pentium II PC
- Windows 98/NT4/2000/ME/XP/VISTA/Windows 7
- 8x-speed CD Rom drive
- SVGA 16 bit display. (32 bit recommended)
- 32 MB of available RAM (128 MB recommended)
- Browser Application (Internet Explorer, Firefox)
- Internet access (to access related internet resources)
