免疫分析/基因探針用的標識藥劑與結合藥劑的市場

本報告已在2011年11月10日停止出版。

更改為出版

免疫測定・基因探針用標識藥劑與結合藥劑

Labeling and Linkage Agents for Immunoassays and Gene Probes

出版日期 : 2011年10月

商品編碼: 223023

簡介

目錄

Abstract

OBJECTIVES AND GOAL OF THE STUDY

This study provides the reader with a detailed analysis of the current consumption and future growth of probes and related chemicals in immunoassays. This study also analyzes the technological developments, future industry trends and emerging business opportunities. Such information will facilitate the investment decisions and strategic planning for business managers.

Major objectives of this study are as follows:

• To assess the technology developments and how they will impact this industry.
• To identify the driving forces for demand.
• To make available the most current and reliable information on consumption of probes and related chemicals in enzyme immunoassays.
• To estimate a global supply and demand scenario broken down by applications and regions.
• To project the growth rate in demand.
• To estimate the projected demand and supply by applications and regions through 2010.
• To profile major companies involved in this business and their market shares.

REASONS FOR DOING THE STUDY

The segment of the diagnostic industry using immunoassays and gene probes is relatively young and undergoing rapid changes spurred on by the on-going progress in biotechnology and medicine. This area is now experiencing major R&D initiatives, resulting in the development of a number of new products, and improvements in the sensitivities and performance of several existing products. This has direct impact on the demand, consumption and future growth of the labeling and linking agents that go into the products.

BCC Research sees the need for a current, comprehensive global report on reagents that make up diagnostic tests. This study attempts to achieve that goal, and provides a comprehensive analysis of the underlying influences brought about by rapid developments in diagnostic products, changes in governmental regulations and the evolving economies of countries such as China and India.

This study also looks at major global players in this field and provides a clear, quantitative picture of a supply and demand scenario, and highlighting future technological trends and investment opportunities in the field.

SCOPE OF THE STUDY

The focus of this study is on the international supply and demand for compounds used in the probes (including gene probes) and related chemicals employed in diagnostic tests and the detection of various antigens/analytes. This study will exclude separation and purification applications, which also can use some of these technologies, but includes our estimates for the emerging market segment for detection brought about by global terrorism threats.

The major industries studied for this report will be:

• In Vitro diagnostics market including:
  • Doctor' offices
  • Medical labs
  • Hospitals testing
  • Home testing (pregnancy, ovulation etc.)
• In Vivo diagnostic imaging reagents
• Blood banks
• Dental markets
• Forensic and paternity market
• Research laboratory markets
• Food testing market
• Environmental market (including bioterrorism detection)

This study gives a greater emphasis on the industries related to human health care, since together they make up the bulk of the market. These include the in vitro diagnostics industry, the in vivo diagnostic imaging industry, blood banks, dental markets and forensic and paternity markets.

It is important to point out that the number of materials covered by this report is large due to the diversity of the materials used. Still, the report does not cover each and every material used in diagnostic testing. First, as the title indicates, we have limited the scope to chemicals used in tagging gene probe or immunoassay products. Next, we do not cover some of the segments that are not related to human health care, such as industrial and veterinary tests. And finally, only chemicals with sufficiently large unit volume demand or dollar value are examined.

The products covered include:

• fluorescent compounds
• radioactive compounds
• enzymes
• enzyme substrates
• chemiluminescent compounds
• gene probes

METHODOLOGY

Information was gathered using both primary and secondary sources. Background information was brought together from a multitude of secondary sources, and complementary and supplementary information was developed with telephone interviews.

Specific analysis includes value chain assessment, strategic positioning maps and life cycle evaluations of both markets and technologies. Technical and regulatory analysis yielded valuable information that facilitated the understanding of the direction and magnitude of market demand for various product segments. The key elements impacting market demand were determined so that specific demand forecasts could be developed for each product.

As might be expected, the diversity of materials used in research applications is far greater than that of commercial areas. This makes forecasting for the segment particularly difficult. However, we have identified the larger volume items and discussed them at length. Market demand forecasts (unit volume and dollar values), are developed for each of the larger volume reagents, and the total demand is determined. Major factors impacting the label/linker supply and demand are discussed. We have examined government regulations, technology developments, patents and international trade. European and Japanese suppliers and markets are also discussed and trade figures are provided. Finally, we arrived at conclusions to facilitate the formation of specific plans of action by industry participants. Although the study is not geared toward any particular supplier, the analysis and conclusions are detailed in a manner that each will find valuable.

CREDENTIALS OF ANALYSTS

The study has been carried out by a team of chemical engineering consultants led by Senior Consultant Mr. N. S. Venkataraman, a chemical engineer with over 30 years of experience in various functions relating to chemical, pharmaceutical and allied industries. Other team members include D. Panneerselvam, Mr. T. K. Parija, Ms. P. Govindanayagi and Ms. K. Geetha. All the members of the team are practicing chemical engineers or chemists with extensive experience as business consultants in the chemical and allied industries.

The project manager for this study was Dr. Yatin B. Thakore, with over 15 years of industry experience in chemical and allied fields.

Table of Contents

• INTRODUCTION
  • OBJECTIVES AND GOAL OF THE STUDY
  • REASONS FOR DOING THE STUDY
  • SCOPE OF THE STUDY
  • TARGETED AUDIENCE
  • METHODOLOGY
  • CREDENTIALS OF ANALYSTS
  • RELATED BCC REPORTS
  • BCC ONLINE SERVICES
  • DISCLAIMER
• SUMMARY
  • Summary Table: MARKETS FOR LABELS AND PROBES BY APPLICATION AREA, THROUGH 2010 ($ MILLIONS)
  • Summary Figure: MARKETS FOR LABELS AND PROBES BY APPLICATION AREA, 2003-2010 ($ MILLIONS)
• TECHNOLOGY OVERVIEW
  • IMMUNOASSAY TECHNOLOGY
    • QUALITATIVE AND QUANTITATIVE IMMUNOASSAYS
    • APPLICATION FIELDS FOR IMMUNOASSAY TECHNIQUES
    • COMPARISON OF IMMUNOASSAYS WITH CONVENTIONAL METHODS
      • High Sensitivity
      • High Selectivity
      • Speed
      • Cost Factors
      • Easier Cleanup Process
      • Efficiency
      • Some Drawbacks
    • ADVANCES IN IMMUNOASSAY TECHNOLOGY
    • METHODS OF IMMUNOASSAYS
      • Immunoprecipitation
      • Particle Immunoassays
      • Radioimmunoassay (RIA)
        • Immuno Radiometric Assays
      • Immunonephelometry and Fluorescent Immunoassay (FIA)
        • Immunonephelometry
        • Fluorescent Immunoassay (FIA)
        • Fluorescence Polarization (FP): Variation of FIA
        • Comparative Performance between EIA and FIA
      • Enzyme Immunoassay (EIA) / Enzyme Linked Immunosorbent Assays (ELISA)
      • Chemiluminecent Assay (CLIA)
      • Examples of Other Immunoassays
    • IMMUNOASSAY TECHNIQUES
      • Monoclonal-Polyclonal (MoAb-PoAb) Sandwich Immunoassay
      • Competitive Inhibition Immunoassay
      • Antigen-Down Immunoassay
      • Rapid Immunoassays
  • GENE PROBE TECHNOLOGY (NUCLEIC ACID ASSAYS)
    • CONSTRUCTION OF PROBES
    • PROBE LABELING
    • NONRADIOACTIVE LABELING OF GENE PROBES
    • IMMUNOASSAY-DNA PROBE HYBRID ASSAYS
    • DETECTION IN FOODS
    • CHIP-BASED NUCLEIC ACID ASSAY
    • REPORTER TECHNOLOGY
      • Chemiluminescent Assays
  • EXAMPLES OF TECHNOLOGY DEVELOPMENTS
    • DETECTION OF DNA HYBRIDIZATION WITH IMPEDANCE AMPLIFYING LABELS
    • QUANTITATIVE FLUORESCENT IMMUNOASSAY OF ANTIBODIES
    • COLORIMETRIC POLYMERASE ASSAY
    • DEVELOPMENT AND PROLIFERATION OF RADIOIMMUNOASSAY TECHNOLOGY
  • HISTORIC MILESTONES IN TECHNOLOGY DEVELOPMENT
    • IMMUNOASSAYS
  • Table 1 IMMUNOASSAYS: HISTORICAL TIMELINE
  • Table 1 (CONTINUED)
    • GENE PROBES
  • Table 2 GENE PROBES: HISTORICAL TIMELINE
    • RADIOACTIVE COMPOUNDS
  • Table 3 RADIOACTIVE COMPOUNDS: HISTORICAL TIMELINE
  • Table 3 (CONTINUED)
• OVERVIEW OF PROBES AND RELATED CHEMICALS
  • RADIOACTIVE COMPOUNDS
  • ENZYMES/ENZYME SUBSTRATES
  • FLUORESCEIN COMPOUNDS
  • CHEMILUMINESCENCE COMPOUNDS
  • GENE PROBES
    • IMMUNOASSAY-DNA PROBE HYBRID ASSAYS
    • FOOD TESTING
  • EXAMPLES OF RADIOACTIVE COMPOUNDS AND THEIR APPLICATIONS
  • Table 4 COMMONLY USED RADIOACTIVE ISOTOPES
  • Table 5 RADIONUCLIDES FOR DIAGNOSTIC IMAGING
    • 99mTc
    • Positron Emitters
  • Table 6 RADIONUCLIDES: POSITRON EMITTERS
  • Table 7 USE OF RADIOACTIVE PROBES: THYROID IMAGING
  • Table 7 (CONTINUED)
  • Table 8 USE OF RADIOACTIVE PROBES: AUTORADIOGRAPHY
  • Table 9 USE OF RADIOACTIVE PROBES: IN DIAGNOSIS AND THERAPY
  • Table 10 USE OF RADIOACTIVE PROBES: RADIOCARDIOGRAPHY
  • Table 11 USE OF RADIOACTIVE PROBES: TUMOR IMAGING
  • Table 12 USE OF RADIOACTIVE PROBES: CANCER TREATMENT
  • Table 13 USE OF RADIOACTIVE PROBES: DETERMINATION OF BLOOD CELL SURVIVAL TIME
  • Table 14 USE OF RADIOACTIVE PROBES: DETERMINATION OF CIRCULATION RED CELL MASS/PLASMA VOLUME
  • Table 15 USE OF RADIOACTIVE PROBES: DETERMINATION OF BLOOD FLOW
  • Table 16 USE OF RADIOACTIVE PROBES: STOMACH IMAGING
  • Table 17 USE OF RADIOACTIVE PROBES: EXCRETION STUDY
  • Table 18 USE OF RADIOACTIVE PROBES: TREATMENT OF LEUKEMIAS
  • Table 19 USE OF RADIOACTIVE PROBES: STUDY OF GASTROINTESTINAL PROTEIN LOSS
  • Table 20 USE OF RADIOACTIVE PROBES: SCANNING LUNGS/BRAIN
  • Table 21 USE OF RADIOACTIVE PROBES: MYOCARDIAL STUDIES
  • Table 22 USE OF RADIOACTIVE PROBES: HEART IMAGING
  • Table 22 (CONTINUED)
  • Table 23 USE OF RADIOACTIVE PROBES: BRAIN IMAGING
  • Table 24 USE OF RADIOACTIVE PROBES: BRAIN PERFUSION IMAGING
  • Table 25 USE OF RADIOACTIVE PROBES: BONE IMAGING
  • Table 26 USE OF RADIOACTIVE PROBES: LUNG IMAGING
  • Table 26 (CONTINUED)
    • Hepatobiliary Imaging
    • Reticuloendothelial System
  • Table 27 USE OF RADIOACTIVE PROBES: RENAL IMAGING
  • Table 28 USE OF RADIOACTIVE PROBES: MALIGNANT AND INFLAMMATORY REGIONS
    • Experimental Agents
    • ENZYME PROBES
  • Table 29 COMMONLY USED TYPE OF EIAS
    • A capture EIA is designed to detect a specific type of antibody, such as IgG or IgM.
  • Table 30 COMMONLY USED ENZYMES IN EIAS
  • Table 31 APPLICATIONS OF ENZYMES IN IMMUNOASSAY
  • Table 31 (CONTINUED)
  • Table 31 (CONTINUED)
    • FLUORESCENCE COMPOUNDS
  • Table 32 COMMONLY USED FLUOROPHORES IN FIA
  • Table 33 FLUOROPHORES AND THEIR APPLICATIONS
  • Table 33 (CONTINUED)
  • Table 33 (CONTINUED)
    • CHEMILUMINESCENT COMPOUNDS
  • Table 34 COMMONLY USED CHEMILUMINESCENT COMPOUNDS
• MARKETS FOR PROBES BY APPLICATION SECTORS
  • GLOBAL MARKET FOR PROBES
  • Table 35 GLOBAL MARKET FOR PROBES IN IMMUNOASSAYS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Table 36 GLOBAL MARKET BY MATERIALS FOR PROBES IN IMMUNOASSAYS, THROUGH 2010 ($ MILLIONS)
  • Figure 1 GLOBAL MARKET BY MATERIALS FOR PROBES IN IMMUNOASSAYS, 2003-2010 ($ MILLIONS)
  • Table 37 REGIONAL SHARE OF THE MARKET FOR PROBES IN IMMUNOASSAYS, THROUGH 2010 ($ MILLIONS)
  • Figure 2 REGIONAL SHARE OF MARKETS FOR PROBES IN IMMUNOASSAYS, 2005 (%)
    • IN VITRO DIAGNOSTICS
  • Table 38 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Figure 3 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
  • Table 39 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY REGION, THROUGH 2010 ($ MILLIONS)
  • Table 40 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY REAGENTS, THROUGH 2010 ($ MILLIONS)
    • Medical Labs
  • Table 41 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS MEDICAL LABS, THROUGH 2010 ($ MILLIONS)
    • Types of Tests
    • Hospital Testing
  • Table 42 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS HOSPITAL TESTING, THROUGH 2010 ($ MILLIONS)
    • Types of Tests
    • Doctors Offices
  • Table 43 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS DOCTORS OFFICE, THROUGH 2010 ($ MILLIONS)
    • Home Testing
  • Table 44 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS HOME TESTING, THROUGH 2010 ($ MILLIONS)
    • Typical Tests
    • Likely Future Trends in the Probes Markets for IVD Sector
    • IN VIVO DIAGNOSTICS
  • Table 45 GLOBAL MARKET FOR PROBES FOR IN VIVO DIAGNOSTICS, THROUGH 2010 ($ MILLIONS)
  • Figure 4 GLOBAL MARKET FOR PROBES FOR IN VIVO DIAGNOSTICS, 2003-2010 ($ MILLIONS)
    • Cancer
    • Ophthalmic
    • Scanning
    • DENTAL
  • Table 46 GLOBAL MARKET FOR PROBES IN THE DENTAL AREA, THROUGH 2010 ($ MILLIONS)
    • BLOOD BANKS
  • Table 47 GLOBAL MARKET FOR PROBES IN BLOOD BANKS, THROUGH 2010 ($ MILLIONS)
    • Types of Tests
    • FOOD TESTING
  • Table 48 GLOBAL MARKET FOR PROBES IN FOOD TESTING, THROUGH 2010 ($ MILLIONS)
    • RESEARCH LABORATORIES
  • Table 49 GLOBAL MARKET FOR PROBES IN RESEARCH LABORATORIES, THROUGH 2010 ($ MILLIONS)
    • Types of Tests
    • FORENSIC AND PATERNITY MARKETS
  • Table 50 MARKET FOR PROBES IN FORENSIC AND PATERNITY, THROUGH 2010 ($ MILLIONS)
  • Table 51 GLOBAL MARKET FOR PROBES IN FORENSIC AND PATERNITY, THROUGH 2010 ($ MILLIONS)
    • Forensics
      • Types of Tests
    • Paternity
      • Types of Tests
    • ENVIRONMENTAL TESTING
  • Table 52 MARKET FOR PROBES IN ENVIRONMENTAL TESTING, THROUGH 2010 ($ MILLIONS)
  • Table 53 GLOBAL MARKET FOR PROBES IN ENVIRONMENTAL TESTING, THROUGH 2010 ($ MILLIONS)
    • Bioterrorism
      • Bioterrorism (Continued)
• MARKET FOR PROBES-BY MATERIALS
  • FLUORESCENT COMPOUNDS
    • REQUIREMENTS FOR FLUORESCENT COMPOUNDS
    • APPLICATIONS OF FLUORESCENCE IMMUNOASSAY
    • FEATURES
      • Nucleic Acid Labeling
      • Protein Labeling
    • COMMONLY USED FLUOROCOMPOUNDS
  • Table 54 APPLICATIONS OF SPECIFIC FLUORESCENT COMPOUNDS
  • Table 54 (CONTINUED)
  • Table 55 MARKET FOR FLUORESCENT COMPOUNDS BY MATERIAL TYPES, THROUGH 2010 ($ MILLIONS)
    • Technology Development
  • Table 56 MARKETS OF FLUORESCENT COMPOUNDS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Figure 5 MARKETS OF FLUORESCENT COMPOUNDS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
    • RADIOACTIVE COMPOUNDS
  • Table 57 MARKET FOR RADIOACTIVE COMPOUNDS BY MATERIAL TYPES, THROUGH 2010 ($ MILLIONS)
    • RADIOACTIVE COMPOUNDS (CONTINUED)
  • Table 58 RADIOPHARMACEUTICALS CURRENTLY USED
  • Table 58 (CONTINUED)
  • Table 58 (CONTINUED)
  • Table 59 MARKETS FOR RADIOACTIVE COMPOUNDS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Figure 6 MARKETS FOR RADIOACTIVE COMPOUNDS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
    • CHEMILUMINESCENT COMPOUNDS
  • Table 60 TYPES OF CHEMILUMINESCENT ASSAY
  • Table 61 TYPES OF LUMINESCENT REACTIONS
    • APPLICATIONS OF CHEMILUMINESCENT COMPOUNDS
    • FACTORS IN CHOOSING A DETECTION REACTION
  • Table 62 MARKET FOR CHEMILUMINESCENT COMPOUNDS BY MATERIAL TYPES, THROUGH 2010 ($ MILLIONS)
  • Table 63 APPLICATIONS OF SELECTED CHEMILUMINESCENT COMPOUNDS
  • Table 64 MARKETS OF CHEMILUMINESCENT COMPOUNDS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Figure 7 MARKETS OF CHEMILUMINESCENT COMPOUNDS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
    • ENZYME/ENZYME SUBSTRATE
  • Table 65 MARKET FOR ENZYMES AND THEIR SUBSTRATES BY TYPE, THROUGH 2010 ($ MILLIONS)
  • Table 66 SELECTED ENZYME IMMUNOASSAY APPLICATIONS
  • Table 66 (CONTINUED)
  • Table 66 (CONTINUED)
  • Table 66 (CONTINUED)
  • Table 66 (CONTINUED)
  • Table 67 MARKETS FOR ENZYMES AND THEIR SUBSTRATES BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Figure 8 MARKETS FOR ENZYMES AND THEIR SUBSTRATES BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
    • GENE PROBES
  • Table 68 MARKET FOR GENE PROBES, THROUGH 2010 ($ MILLIONS)
  • Table 69 MARKETS FOR GENE PROBES BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
  • Figure 9 MARKETS FOR GENE PROBES BY APPLICATION SECTORS, 2003- 2010 ($ MILLIONS)
• REGULATIONS AFFECTING THE INDUSTRY
  • REGULATIONS AFFECTING RADIOACTIVE MATERIALS
  • Table 70 HISTORICAL TIMELINE OF REGULATIONS AFFECTING THE HANDLING OF RADIOISOTOPES IN THE U.S.
  • Table 70 (CONTINUED)
    • NUCLEAR REGULATORY COMMISSION (NRC) REGULATIONS
    • PRESENT RULES AND REGULATIONS
    • SAFETY STANDARDS
    • MEDICAL USE POLICY STATEMENT
    • ADVISORY COMMITTEE
  • Table 71 HIGHLIGHTS OF DEVELOPMENTS IN NRC REGULATIONS
    • REGULATIONS RELATING TO STORAGE OF RADIO ISOTOPES
    • SINK DISPOSAL
    • EXEMPTION TO SMALL QUANTITY ISOTOPES
    • EUROPEAN REGULATIONS ON WASTE DISPOSAL
    • PERMITS FOR THE IMPORT OF MEDICAL RADIOISOTOPES IN AUSTRALIA
      • PERMITS FOR THE IMPORT OF MEDICAL�ECONTINUED)
• GLOBAL HEALTHCARE AND INDUSTRY TRENDS
  • WORLD POPULATION AND DISEASE PROFILE
    • WORLD POPULATION AND GROWTH RATE
  • DISEASE PROFILE
    • KEY DETERMINANTS OF HEALTH
      • Key Determinants of Health (Continued)
      • Infectious Diseases
    • PATIENT CARE
  • Table 72 HOSPITAL BED STATISTICS FOR SELECTED COUNTRIES, 2004
    • DRIVING FACTORS OF TESTING IN DEVELOPING COUNTRIES
    • DRIVING FACTORS IN DEVELOPED COUNTRIES
    • CONSTRAINTS FOR GROWTH
    • THE STAKEHOLDERS
    • TECHNOLOGY FACTORS
      • ULTRATRACE
    • FACTORS INFLUENCING GROWTH
      • EXTENT OF UTILIZATION OF IVD PROCEDURES
    • GROWTH IN CONSUMPTION
    • PATTERN OF USE
    • HALF LIFE AND LIMITED AVAILABILITY IN SOME COUNTRIES
    • ENVIRONMENTAL ISSUES
      • OPTIONS FOR MINIMIZING RADIOACTIVE WASTE DISPOSAL PROBLEMS
    • COST ISSUES
    • SUBSTITUTION FOR RADIOISOTOPES
      • FUTURE FOR RADIOACTIVE PROBES
    • FUTURE FOR CHEMILUMINESCENT PROBES
    • FUTURE FOR ENZYME-BASED ASSAYS
    • FUTURE FOR FLUORESCENT PROBES
    • FUTURE FOR GENE PROBES
• PROBES-TECHNOLOGY AND PATENTS
  • FLUORESCENT COMPOUNDS
    • ELECTRONIC ARRAY DETECTORS
    • ASSAY SENSITIVITY AND TAGGING METHODS
    • SIMULTANEOUS ANALYSIS OF MULTIPLE SAMPLES FOR MULTIPLE ANALYTES
    • DIFFUSION IMMUNOASSAY (DIA)
    • STOPPED-FLOW FLUORESCENCE POLARIZATION IMMUNOASSAY
    • THE USE OF FLUORESCENCE POLARIZATION ASSAYS FOR THE DETECTION OF INFECTIOUS DISEASES
    • TISSUE AUTO FLUORESCENCE
  • CHEMILUMINESCENT COMPOUNDS
    • ASSAY SENSITIVITY AND TAGGING METHODS
    • BIOLUMINESCENT TAGS
    • CK-MB TEST
  • RADIOACTIVE COMPOUNDS
    • DIAGNOSIS OF INFECTIOUS AND INFLAMMATORY DISEASE
  • Table 73 DEVELOPMENTS IN RADIOLABELED COMPOUNDS
    • RADIOLABELED PEPTIDES FOR DIAGNOSIS AND THERAPY
    • USE OF LOW RADIATION DOSE
    • ENZYMES/ENZYME SUBSTRATES
      • DIAGNOSIS OF CEREBRAL ASPERGILLOSIS
      • NUCLEIC ACID MODIFYING ENZYMES
      • DIAGNOSIS OF RENAL DISORDERS
      • THE DIAGNOSIS OF TRYPANOSOMOSIS IN ANIMALS
      • DIAGNOSIS OF ECTOPIC PREGNANCY
    • IMMUNOASSAYS
      • MARKERS FOR RISK STUDY
      • DEVELOPMENT OF MONOCLONAL ANTIBODIES
      • ASSAY SENSITIVITY AND TAGGING METHODS
      • MOLECULAR BIOLOGY TECHNIQUES
    • GENE PROBES
      • RECENT DEVELOPMENTS IN NUCLEIC ACID HYBRIDIZATION
      • REAL-TIME POLYMERASE CHAIN REACTION (PCR) TESTING
      • TIME RESOLVED FLUORESCENT (TRF) IMMUNOASSAY TESTING
      • DIAGNOSIS OF MYOCARDIAL INFARCTION
      • TOOLS FOR REAGENT IMMOBILIZATION
        • Beads
        • Dots
        • Paramagnetic Particles
        • Tools for Sample Collection
        • Matrices for Test Development
        • Interferences in Immunoassays
        • Demand for Early Risk and Disease Detection
        • Machinery and Platforms
    • PATENT ANALYSIS
  • Table 74 PATENT ANALYSIS FOR SELECTED ORGANIZATIONS
    • DESCRIPTION OF SOME REPRESENTATIVE PATENTS
      • New Imaging Agent for CNS Disorders
        • Fluorobutenyl Tropanes for Mapping Transporter Sites
        • Halogenated Pyrroloisoquinolines for Mapping Serotonin Transporter Sites
      • Detection of Prostrate Cancer
        • Diagnosis and Monitoring of Prostate Cancer Patients by Measurement of Serum
      • Detection of Neurological Diseases
        • Method of Detecting Axonally-Derived Protein Tau in Patients With Traumatic CNS Injury
        • Method of Analyzing Ataxia-Telangiectasia Protein
        • Detection of Transmissible Spongiform Encephalopathies (Tses)
      • Simultaneous Generation of Multiple Chemiluminescent Signals on Solid Supports
      • Monoclonal Anti-Human Breast Cancer Antibodies
      • Autonomous Ingestible Probe for Diagnosis and Therapy of Gastrointestinal Lesions Using Fluorescent Molecules
      • Biochip Devices for Genetic Analyses
        • New Biochip Methods and Devices That Reduce the Cost and Complexity of Performing Genetic Analyses.
        • Biochip Devices For Genetic Analyses (Continued)
• PROFILE OF MAJOR PLAYERS
  • MARKET SHARE OF MAJOR PLAYERS
  • Table 75 MARKET SHARE OF MAJOR PLAYERS IN MEDICAL DIAGNOSTICS
    • ABBOTT LABORATORIES
      • HIGHLIGHTS
      • PRODUCT RANGE
        • Immunoassay
  • Table 76 REPRESENTATIVE ASSAY PRODUCTS OF ABBOTT
    • ACTIVITIES
    • FACILITIES
    • COLLABORATION
  • Table 77 SOME IMPORTANT COLLABORATION EFFORTS AT ABBOTT
  • Table 77 (CONTINUED)
    • AMERSHAM BIOSCIENCES, USA
      • BACKGROUND DETAILS
      • PRODUCT RANGE
      • ACTIVITY
      • FACILITIES
        • Research and Development
        • Global Operations
    • BACHEM AG
      • GMP PRODUCTION SITES
      • MANUFACTURING CAPABILITIES
      • MAJOR MILESTONES FOR BACHEM
  • Table 78 MAJOR MILESTONES FOR BACHEM
    • ASSOCIATED UNITS
  • Table 79 BACHEM UNITS
  • Table 79 (CONTINUED)
    • PRODUCT RANGE
      • Sera and Antibody Products
      • ELISA Kits
      • Research Reagents
      • Custom Iodination 125i-Labelling
    • FACILITIES
    • COLLABORATIONS
  • Table 80 BACHEM COLLABORATIONS
  • Table 80 (CONTINUED)
    • BIOFX LABORATORIES
      • LOCATIONS
      • PRODUCT RANGE
        • Microwell Substrate
        • Membrane Substrate
        • Microwell ELISA - Peroxidase Enzyme Systems
      • OTHER DETAILS
        • New Chemiluminescent Product for Peroxidase Enzyme Systems
    • BIO-NUCLEONICS INC.
      • ACTIVITIES
      • COLLABORATION AND ALLIANCE PARTNER
        • Patents
    • BIO-RAD, USA
      • PRODUCT RANGE
    • BIOTIUM, USA
      • PRODUCT RANGE
        • Fluorescent Calcium Indicators and Related Products
        • Fluorescent Indicators (Chloride, Ph, Etc.)
          • Chloride Indicators
          • Ph Indicators
          • Zinc Indicators
          • Enzyme Indicator
      • ACTIVITIES
    • BIOVECTRA DCL, USA
      • PRODUCT RANGE
        • Enzymes
  • Table 81 PRODUCT RANGE AND APPLICATION OF BIOVECTRA DCL
    • ACTIVITIES
    • BIOZYME LABORATORIES
      • PRODUCT RANGE
    • CARBOMER INC.
      • ACTIVITIES
      • PRODUCT RANGE
        • Fluorescent Reagents
        • Fluorescent Glycans
    • DIAGNOSTIC CHEMICALS LIMITED, USA
      • PRODUCT RANGE
      • ACTIVITY
      • OTHER DETAILS
        • L3K Technology
          • Immunodiagnostics
    • DUTCH DIAGNOSTICS
      • PRODUCT RANGE
    • HYTEST LTD.
      • PRODUCT RANGE
  • Table 82 REPRESENTATIVE PRODUCTS OF HYTEST
  • Table 82 (CONTINUED)
    • INSTITUTE OF ISOTOPE CO. LTD., HUNGARY
      • ACTIVITY
      • PRODUCT RANGE
        • Radionuclides
        • Radiochemicals
      • FACILITIES
    • INTERNATIONAL MUREX TECHNOLOGIES CORPORATION /
    • MUREX DIAGNOSTICS CORP.
      • MANUFACTURING PLANTS
      • PRODUCT RANGE
      • MILESTONES
    • LUMIGEN, INC
      • PRODUCT RANGE
  • Table 83 REPRESENTATIVE PRODUCTS OF LUMIGEN
    • Lumigens LMO Technology
    • MDS NORDION
      • EXPERTISE
      • PRODUCT RANGE
      • ACTIVITY
      • FACILITIES
      • COLLABORATION
  • Table 84 REPRESENTATIVE COLLABORATION EFFORTS OF MDS
  • Table 84 (CONTINUED)
    • MORAVEK BIOCHEMICALS, USA
      • ACTIVITY
      • PRODUCT RANGE
    • PERKINELMER LIFE SCIENCE, INC.
      • ACTIVITY
      • PRODUCT RANGE
        • Fluorescein-12-Dutp
        • NEN Brand Fluorescent Nucleotide Analogs
    • RESEARCH PRODUCTS INTERNATIONAL CORP., USA
      • PRODUCT RANGE
    • SIGMA ALDRICH, USA
      • ACTIVITIES
  • Table 85 MILESTONES FOR SIGMA ALDRICH
    • PRODUCT RANGE
      • Enzymes
      • Fluorescent Labels
        • Amine Derivatives
    • THERATASE, PLC
      • BACKGROUND DETAILS
      • PRODUCT RANGE
      • COLLABORATION
    • TOYOBO ENZYMES
      • FACILITIES
      • PRODUCT RANGE
  • Table 86 REPRESENTATIVE PRODUCTS OF TOYOBO
    • VECTOR LABS
      • PRODUCT RANGE
  • Table 87 REPRESENTATIVE PRODUCTS OF VECTOR LABS
  • Table 87 (CONTINUED)
    • ZYMED LABORATORIES, INC., USA
      • PRODUCT RANGE
        • Other Products
• LIST OF TABLES
• Summary Table:
• Table 1 IMMUNOASSAYS: HISTORICAL TIMELINE
• Table 2 GENE PROBES: HISTORICAL TIMELINE
• Table 3 RADIOACTIVE COMPOUNDS: HISTORICAL TIMELINE
• Table 4 COMMONLY USED RADIOACTIVE ISOTOPES
• Table 5 RADIONUCLIDES FOR DIAGNOSTIC IMAGING
• Table 6 RADIONUCLIDES: POSITRON EMITTERS
• Table 7 USE OF RADIOACTIVE PROBES: THYROID IMAGING
• Table 8 USE OF RADIOACTIVE PROBES: AUTORADIOGRAPHY
• Table 9 USE OF RADIOACTIVE PROBES: IN DIAGNOSIS AND THERAPY
• Table 10 USE OF RADIOACTIVE PROBES: RADIOCARDIOGRAPHY
• Table 11 USE OF RADIOACTIVE PROBES: TUMOR IMAGING
• Table 12 USE OF RADIOACTIVE PROBES: CANCER TREATMENT
• Table 13 USE OF RADIOACTIVE PROBES: DETERMINATION OF BLOOD CELL SURVIVAL TIME
• Table 14 USE OF RADIOACTIVE PROBES: DETERMINATION OF CIRCULATION RED CELL MASS/PLASMA VOLUME
• Table 15 USE OF RADIOACTIVE PROBES: DETERMINATION OF BLOOD FLOW
• Table 16 USE OF RADIOACTIVE PROBES: STOMACH IMAGING
• Table 17 USE OF RADIOACTIVE PROBES: EXCRETION STUDY
• Table 18 USE OF RADIOACTIVE PROBES: TREATMENT OF LEUKEMIAS
• Table 19 USE OF RADIOACTIVE PROBES: STUDY OF GASTROINTESTINAL PROTEIN LOSS
• Table 20 USE OF RADIOACTIVE PROBES: SCANNING LUNGS/BRAIN
• Table 21 USE OF RADIOACTIVE PROBES: MYOCARDIAL STUDIES
• Table 22 USE OF RADIOACTIVE PROBES: HEART IMAGING
• Table 23 USE OF RADIOACTIVE PROBES: BRAIN IMAGING
• Table 24 USE OF RADIOACTIVE PROBES: BRAIN PERFUSION IMAGING
• Table 25 USE OF RADIOACTIVE PROBES: BONE IMAGING
• Table 26 USE OF RADIOACTIVE PROBES: LUNG IMAGING
• Table 27 USE OF RADIOACTIVE PROBES: RENAL IMAGING
• Table 28 USE OF RADIOACTIVE PROBES: MALIGNANT AND INFLAMMATORY REGIONS
• Table 29 COMMONLY USED TYPE OF EIAS
• Table 30 COMMONLY USED ENZYMES IN EIAS
• Table 31 APPLICATIONS OF ENZYMES IN IMMUNOASSAY
• Table 32 COMMONLY USED FLUOROPHORES IN FIA
• Table 33 FLUOROPHORES AND THEIR APPLICATIONS
• Table 34 COMMONLY USED CHEMILUMINESCENT COMPOUNDS
• Table 35 GLOBAL MARKET FOR PROBES IN IMMUNOASSAYS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 36 GLOBAL MARKET BY MATERIALS FOR PROBES IN IMMUNOASSAYS, THROUGH 2010 ($ MILLIONS)
• Table 37 REGIONAL SHARE OF THE MARKET FOR PROBES IN IMMUNOASSAYS, THROUGH 2010 ($ MILLIONS)
• Table 38 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 39 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY REGION, THROUGH 2010 ($ MILLIONS)
• Table 40 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY REAGENTS, THROUGH 2010 ($ MILLIONS)
• Table 41 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS MEDICAL LABS, THROUGH 2010 ($ MILLIONS)
• Table 42 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS HOSPITAL TESTING, THROUGH 2010 ($ MILLIONS)
• Table 43 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS DOCTORS OFFICE, THROUGH 2010 ($ MILLIONS)
• Table 44 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS HOME TESTING, THROUGH 2010 ($ MILLIONS)
• Table 45 GLOBAL MARKET FOR PROBES FOR IN VIVO DIAGNOSTICS, THROUGH 2010 ($ MILLIONS)
• Table 46 GLOBAL MARKET FOR PROBES IN THE DENTAL AREA, THROUGH 2010 ($ MILLIONS)
• Table 47 GLOBAL MARKET FOR PROBES IN BLOOD BANKS, THROUGH 2010 ($ MILLIONS)
• Table 48 GLOBAL MARKET FOR PROBES IN FOOD TESTING, THROUGH 2010 ($ MILLIONS)
• Table 49 GLOBAL MARKET FOR PROBES IN RESEARCH LABORATORIES, THROUGH 2010 ($ MILLIONS)
• Table 50 MARKET FOR PROBES IN FORENSIC AND PATERNITY, THROUGH 2010 ($ MILLIONS)
• Table 51 GLOBAL MARKET FOR PROBES IN FORENSIC AND PATERNITY, THROUGH 2010 ($ MILLIONS)
• Table 52 MARKET FOR PROBES IN ENVIRONMENTAL TESTING, THROUGH 2010 ($ MILLIONS)
• Table 53 GLOBAL MARKET FOR PROBES IN ENVIRONMENTAL TESTING, THROUGH 2010 ($ MILLIONS)
• Table 54 APPLICATIONS OF SPECIFIC FLUORESCENT COMPOUNDS
• Table 55 MARKET FOR FLUORESCENT COMPOUNDS BY MATERIAL TYPES, THROUGH 2010 ($ MILLIONS)
• Table 56 MARKETS OF FLUORESCENT COMPOUNDS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 57 MARKET FOR RADIOACTIVE COMPOUNDS BY MATERIAL TYPES, THROUGH 2010 ($ MILLIONS)
• Table 58 RADIOPHARMACEUTICALS CURRENTLY USED
• Table 59 MARKETS FOR RADIOACTIVE COMPOUNDS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 60 TYPES OF CHEMILUMINESCENT ASSAY
• Table 61 TYPES OF LUMINESCENT REACTIONS
• Table 62 MARKET FOR CHEMILUMINESCENT COMPOUNDS BY MATERIAL TYPES, THROUGH 2010 ($ MILLIONS)
• Table 63 APPLICATIONS OF SELECTED CHEMILUMINESCENT COMPOUNDS
• Table 64 MARKETS OF CHEMILUMINESCENT COMPOUNDS BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 65 MARKET FOR ENZYMES AND THEIR SUBSTRATES BY TYPE, THROUGH 2010 ($ MILLIONS)
• Table 66 SELECTED ENZYME IMMUNOASSAY APPLICATIONS
• Table 67 MARKETS FOR ENZYMES AND THEIR SUBSTRATES BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 68 MARKET FOR GENE PROBES, THROUGH 2010 ($ MILLIONS)
• Table 69 MARKETS FOR GENE PROBES BY APPLICATION SECTORS, THROUGH 2010 ($ MILLIONS)
• Table 70 HISTORICAL TIMELINE OF REGULATIONS AFFECTING THE HANDLING OF RADIOISOTOPES IN THE U.S.
• Table 71 HIGHLIGHTS OF DEVELOPMENTS IN NRC REGULATIONS
• Table 72 HOSPITAL BED STATISTICS FOR SELECTED COUNTRIES, 2004
• Table 73 DEVELOPMENTS IN RADIOLABELED COMPOUNDS
• Table 74 PATENT ANALYSIS FOR SELECTED ORGANIZATIONS
• Table 75 MARKET SHARE OF MAJOR PLAYERS IN MEDICAL DIAGNOSTICS
• Table 76 REPRESENTATIVE ASSAY PRODUCTS OF ABBOTT
• Table 77 SOME IMPORTANT COLLABORATION EFFORTS AT ABBOTT
• Table 78 MAJOR MILESTONES FOR BACHEM
• Table 79 BACHEM UNITS
• Table 80 BACHEM COLLABORATIONS
• Table 81 PRODUCT RANGE AND APPLICATION OF BIOVECTRA DCL
• Table 82 REPRESENTATIVE PRODUCTS OF HYTEST
• Table 83 REPRESENTATIVE PRODUCTS OF LUMIGEN
• Table 84 REPRESENTATIVE COLLABORATION EFFORTS OF MDS
• Table 85 MILESTONES FOR SIGMA ALDRICH
• Table 86 REPRESENTATIVE PRODUCTS OF TOYOBO
• Table 87 REPRESENTATIVE PRODUCTS OF VECTOR LABS
• LIST OF FIGURES
• Summary Figure:
• Figure 1 GLOBAL MARKET BY MATERIALS FOR PROBES IN IMMUNOASSAYS, 2003-2010 ($ MILLIONS)
• Figure 2 REGIONAL SHARE OF MARKETS FOR PROBES IN IMMUNOASSAYS, 2005 (%)
• Figure 3 GLOBAL MARKET FOR PROBES FOR IN VITRO DIAGNOSTICS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
• Figure 4 GLOBAL MARKET FOR PROBES FOR IN VIVO DIAGNOSTICS, 2003-2010 ($ MILLIONS)
• Figure 5 MARKETS OF FLUORESCENT COMPOUNDS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
• Figure 6 MARKETS FOR RADIOACTIVE COMPOUNDS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
• Figure 7 MARKETS OF CHEMILUMINESCENT COMPOUNDS BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
• Figure 8 MARKETS FOR ENZYMES AND THEIR SUBSTRATES BY APPLICATION SECTORS, 2003-2010 ($ MILLIONS)
• Figure 9 MARKETS FOR GENE PROBES BY APPLICATION SECTORS, 2003- 2010 ($ MILLIONS)

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