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市場調查報告書

培養3D細胞:技術和全球市場

3D Cell Cultures: Technologies and Global Markets

出版商 BCC Research 商品編碼 320803
出版日期 內容資訊 英文 290 Pages
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培養3D細胞:技術和全球市場 3D Cell Cultures: Technologies and Global Markets
出版日期: 2017年05月30日 內容資訊: 英文 290 Pages
簡介

2016年培養3D細胞市場達到了10億美元的規模。預測從2016年到2021年將以42.6%的年複合成長率推移,到2021年成長到39億美元的規模。

本報告提供培養3D細胞技術及市場相關調查,提供組織培養·細胞培養概要,3D技術類型和概要,價值鏈分析,市場規模的變化與預測,各用途詳細內容,市場影響因素及市場機會分析,專利趨勢,並彙整主要企業的簡介等資訊。

第1章 簡介

第2章 摘要及亮點

第3章 市場及技術背景

  • 組織及細胞培養
  • 組織
  • 細胞
  • 組織培養·細胞培養定義
  • 細胞培養的獲得
  • 細胞類型:以形態為主
  • 細胞類型:以雜交瘤為主
  • 細胞培養:基礎必要條件
  • 基本的細胞培養系統
  • 歷史與早期應用

第4章 組織·細胞培養系統環境

  • 生物藥物及疫苗的大規模製造
  • 體細胞,幹細胞及細胞生成用小規模細菌
  • 技術概要:細胞培養類別
  • 附著方法
  • 3D生物反應器
  • 再生醫療的利用
  • 細胞培養:初期3D的先驅者
  • 收益估計

第5章 研究環境和培養3D細胞所使用的消耗品

  • 微孔盤
  • CELLOMICS概要
  • 2D培養 vs 3D培養
  • 主要供應商
  • 高通量篩檢(HTS)用途
  • 培養3D細胞技術化驗的 開放式·革新·平台.

第6章 3D技術和基本的產品

  • 提供微量滴定板的平台
  • 培養3D細胞技術
  • 2D及3D系統的重要性
  • 基本培養3D細胞可變因素
  • 3D技術與產品
  • 器官及原形質類器官
  • 再生醫療的組織工程
  • 皮膚替代品產業
  • 美國對生物印刷產品的法規情形
  • 器官移植
  • 收購及策略性聯盟
  • 收益摘要
  • 市場估計

第7章 癌症的3D模式

  • 癌症:細胞層級概要
  • 最新的方法
  • 體內(動物)檢驗標準
  • 3D的必要條件
  • 癌症研究的3D的優點
  • 3D培養的推進因素的乳癌
  • 3D培養的推進因素的黑色素瘤
  • 癌症研究的3D系統
  • 3D培養推動者
  • 來自藥物敏感性及藥物抗性的學習
  • 細胞資訊
  • 藥物篩檢
  • 癌症的代謝性
  • 未來性
  • 患者來歷的細胞
  • PDC平台的演進
  • 體內模式
  • 結合體外與NGS
  • 收益預測

第8章 毒性·醫藥品安全性檢驗環境

  • 毒物學的背景
  • 化妝品及藥用化妝品的有效性
  • 生物印刷
  • 慢性毒性·多次投藥毒性實驗
  • 致癌性及遺傳毒性
  • 生殖·發生毒性實驗
  • 內分泌攪亂物質篩檢
  • 毒物動力學和ADME
  • 體外的發展
  • 器官型模式
  • 吸收障礙模式
  • 腎臟毒性
  • 肝臟的固有性和複雜性
  • 3D的創新的主要推進因素的肝臟
  • 體外肝臟用途
  • 體內肝臟功能與結構
  • 肝臟的代謝
  • 肝臟體外模式
  • 肝細胞和巨噬細胞的混合培養
  • 3D肝臟模式
  • 肝組織的生物印刷等

第9章 幹細胞的3D培養所扮演的角色

  • 簡介
  • 初期的學習
  • 胚形成
  • 3D幹細胞培養系統
  • 胚先生體形成的控制
  • 用途
  • 情形及促進要素
  • FUJIFILM (Cellular Dynamics Inc.)
  • 從肝細胞研究所得的突破
  • 收益估計

第10章 3D的下一代的展望

  • 概要
  • 癌症
  • 預測的毒物學
  • 神經科學的發現與發展的幹細胞
  • 心血管上的發現的幹細胞
  • 再生醫療的發展的幹細胞
  • 收益估計
  • 附錄:肝臟

第11章 企業簡介

附錄:專利分析

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目錄
Product Code: BIO140B

The three-dimensional cell culture market reached $1.0 billion in 2016 and should reach $3.9 billion in 2021, with a compound annual growth rate (CAGR) of 42.6% from 2016 to 2021.

Report Includes

  • An overview of the global markets and technologies for 3D cell cultures.
  • Analyses of global market trends, with data from 2015, estimates for 2016, and projections of compound annual growth rates (CAGRs) through 2021.
  • Information on 3D technologies, with a focus on representative platforms, including cube, spherical droplet, stacked plate, magnetic bead, and other platforms.
  • Value-chain analysis at the following levels: key innovation or founding intellectual property, prototyping, beta testing, and research collaborations or relationship building.
  • Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities.
  • Relevant patent analysis, including recent activity and a list of key patents.
  • Profiles of major players in the industry.

Report Scope

The scope of the report encompasses the major types of 3D cell culture that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

Analyst Credentials

Robert G. Hunter is a senior management consultant, commercialization consultant and technology and market analyst with over 20 years of experience in life sciences and healthcare. Recent consulting includes market/technology analysis and forecasting of customer adoption and revenue for a high content screening (HCS) technology leader. He is an early investor in a company using stem cells for predictive drug safety testing in vitro. He has a B.S. in Mechanical Engineering from Clemson University and Master of Business Administration from The Tuck School of Business at Dartmouth.

Table of Contents

Chapter 1: Introduction

  • Study Goals and Objectives.
  • Reasons for Doing the Study
  • Scope of Report
  • Intended Audience
  • Methodology and Information Sources
  • Analyst's Credentials
  • Related BCC Research Reports

Chapter 2: Summary and Highlights

  • New Applications Identified Since 2015 Report
  • Changes from 2015 Report

Chapter 3: Market and Technology Background

  • Tissue and Cell Culture
  • Tissue
  • Cells
    • Cell Types
  • Tissue Culture and Cell Culture Definitions
  • Obtaining Cell Cultures
    • Isolating Cells from Tissues
    • Maintaining Cells in Culture
    • Plating Density and Sub-culturing
    • Cryogenic Storage.
    • Obtaining Cells from Other Sources: Issue of Cross-contamination
  • Cell Types Based on Morphology
  • Cell Types Based on Hybridomas
  • Cell Culture: Basic Requirements
    • Avoiding Contamination
    • Important Indicators of Cell Culture Health
    • Maintaining Optimal Cell Culture Conditions
  • Basic Cell Culture Systems
    • Adherent Cells Requiring Attachment Substrate
    • Suspension Cell Cultures
  • History and Early Applications
    • Invention of Tissue Culture
    • Development of Sustained Cell Lines
    • First Cell Culture Flask and Rigorous Techniques
    • Lindbergh: The Cell Culture Equipment Pioneer
    • Establishing Continuous Cell Lines
    • Key Developments in Equipment
    • Vaccine Development as Catalyst
    • Cell Strains and Cell Lines
    • Vaccines Developed Using Human Cell Strains
    • Continued Catalyst

Chapter 4: Tissue and Cell Culture Systems Landscape

  • Large-Scale Manufacture of Biopharmaceuticals and Vaccines
    • Suspension Proteins and Monoclonal Antibodies
    • Adherent-Cell-based Therapies and Vaccines
  • Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues
  • Technology Overview by Cell Culture Type
    • Suspension Approaches
    • Innovation and Challenges
    • Single-Use Technology
    • Mini- and MicroBioreactors: Clone Selection and Development
  • Adherent Approaches
    • Traditional Roller Bottles
    • Other Systems
    • New Understanding of Cell Attachment and Detachment
  • Three-dimensional Bioreactors
  • Applications in Regenerative Medicine
  • Tissue Culture - Early 3D Pioneers
  • Revenue Estimate

Chapter 5: Research Landscape and Products Used in Three-dimensional Cell Culture

  • Microplates
    • Standards Setting
    • Continuous Innovation
    • Microplate Readers
    • Liquid-Handling Equipment
  • Cellomics Overview
    • Fluorescence as Driver of Screening
    • High Content Screening
    • Imaging Advances
    • Flow Cytometry
    • Future Vision for High-content Screening
    • Label-Free Platforms
    • Electrophysiology
    • Assays and Assay Kits
    • Cell-Based Assays: Overview and Newer Developments
    • Cells Used in Cell-Based Assays
  • Two-dimensional Cultures vs. Three-dimensional Cultures
  • Key Suppliers
  • Basic 3D Cell Culture Variables
    • Cell Adhesion
    • Cell Migration
    • Cell Invasion.
    • Viability and Cytotoxicity
    • Cell Signaling and Communication
    • Enhanced Functionality and Confirming Assays
    • Cytotoxicity: A Major Category
    • Permeability Assays for Cell Viability and Survival
    • Metabolic Assays for Cell Viability and Survival
    • Cell Death Assays
    • Cytostatic or Long-Term Impact Assays
    • Multiplex Assays
    • Composite Screening Strategies
  • High Throughput Screening (HTS) Applications
    • Three-dimensional Cytotoxicity Applications.
    • Correlation with Gene-Expression Data
    • 1,536-Well Formats
    • Kinetic Metabolism Assays
  • 3D Assay Open Innovation Platform

Chapter 6: Three-dimensional Technologies and Basic Products

  • Microtiter Plates Provide Platform
    • Supportive Standards
    • Microplate Well Inserts
  • Three-dimensional Cell Culture Technologies
    • Three-dimensional Adoption Status
  • Importance of 2D vs. 3D Systems
    • Paracrine vs. Autocrine Signaling
  • Basic 3D Cell Culture Variables
    • Cell Adhesion
    • Cell Migration
    • Cell Invasion.
    • Basic Assay Types
  • Three-dimensional Technology and Products
    • Three-dimensional Matrices to Replicate the Extracellular Matrix
    • Foundational Tools: Gels and Basement Membranes
    • Scaffolds
    • Examples of Innovation
    • Scaffold-Free Formats
    • Applications Overview
    • Analytical Methods
    • Imaging
    • Liquid Handling
    • High-throughput Screening Capability
    • Continued Spheroid Adoption
    • Organotypic Models
    • Directional Culture
    • Microfluidics
    • Glass/Silicon-Based Platforms
    • Polymer-based Platforms
    • Chip Technology
    • Organ/Tissue-On-Chip Industry
    • Bioprinting
    • Current Dominant Technologies
    • Bioprint Instrument Industry
    • Bioink Technologies
    • Bioink Industry
    • Applications
    • Toxicology Testing in Cosmetics
  • Organs and Organoids
    • Organoids
  • Tissue Engineering in Regenerative Medicine
  • Skin Substitutes Industry
    • Recent Example: Skin and Hair
    • U.S. Regulatory Status of Bioprinted Products
  • Organ Transplants
  • Acquisitions and Strategic Alliances
  • Regenerative Medicine
    • Future Challenges
    • Increasing Integration and Evolution
  • Revenue Summary
  • Market Estimate

Chapter 7: Three-dimensional Models for Cancer

  • Cancer at the Cellular Level Overview
  • Approaches to Date
  • In Vivo (Animal) Testing Standard
    • Xenografts
    • Two-dimensional Learnings and Drawbacks
  • Three-dimensional Requirements
    • Cell Number and Viability
    • Migration and Invasion
    • Unmet Needs: Angiogenesis and Immune System Evasion
  • Three-dimensional Benefits to Cancer Research
    • Greater Distinction in Cell Morphology and Proliferation
    • Greater Gene Expression and Cell Behavior
    • Better Models of Cell Migration and Invasion
    • Cell Heterogeneity
  • Breast Cancer as a Driver of Three-dimensional Cultures
    • Structure, Polarity and Apoptosis
  • Melanoma as a Driver of Three-dimensional Cultures
    • Moving to Spheroid Configurations
  • Three-dimensional Systems in Cancer Research
    • Multicellular Tumor Spheroids
    • Multilayered Cell Cultures
  • Three-dimensional Engineered Scaffolds
    • Natural Materials
    • Synthetic Materials
  • Learnings from Drug Sensitivity and Resistance
    • Altered Signaling and Sensitivity
    • Drug Resistance
  • Cellular Signaling
    • Cellular Signaling Mediated by Integrins
  • Drug Screening
    • Approaches and Endpoints
    • Spheroids Applications
    • Metastasis via Three-dimensional Cell Migration Model
    • Metastasis via Lung-on-Chip
  • Cancer Metabolism
  • Future Horizons
    • Metastases
    • Co-culture
    • Vascularization
    • Cancer-associated Fibroblasts
    • Cancer Stem Cells
    • Combination Therapies
    • Biologics Development
    • Tumor Recurrence
  • Patient-derived Cells
    • Patient-derived Tumor Xenografts
  • Evolution of PDX Platforms
  • Ex Vivo Models
    • Ex Vivo Applications
    • Ex Vivo Shortcomings
    • Ex Vivo PDX in 3D Cell Culture
  • Combining Ex Vivo with NGS
    • Preserving Heterogeneity in Cancer Models
    • High-Throughput Drug Screening
  • Revenue Forecast

Chapter 8: Landscape for Toxicology and Drug Safety Testing

  • Toxicology Background
    • Testing for Adverse Effects on the Skin
    • Toxicology Testing in Cosmetics
    • Updated Regulatory Requirements
  • Efficacy of Cosmetics and Cosmeceuticals
  • Bioprinting
    • Skin Irritation
    • Skin Corrosion
    • Phototoxicity
    • Skin Sensitization
    • Eye Irritation
    • Acute Systemic Toxicity
    • Acute Toxicity Testing
    • Cytotoxicity Assays for Acute Toxicity Testing
  • Chronic and Repeated Dose Toxicity
    • Chronic and Repeated Dose Toxicity Study Goals
    • Development of Repeated Dose Toxicity Testing In Vitro
  • Carcinogenicity and Genotoxicity
    • Overview
    • In Vitro Methods: Background and Recent Developments
    • Regulatory vs. Drug Development Applications
    • Efforts to Reduce False Positives
    • Recent Innovations for Screening
    • Future Challenge: Non-Genotoxic Carcinogens
  • Reproductive and Developmental Toxicity
    • Background
    • Following the Reproductive Cycle
    • Development and Reproductive Tox Testing Types
    • Zebrafish Model for Developmental Toxicity Screening
    • Combinations of Zebrafish and Stem Cells
    • Biomedical Frontiers: Male Testis
  • Endocrine Disruptor Screening
    • Background
    • Environmental Toxicology Impacts In Vitro Methods
    • High-Production Volume Chemicals
    • ToxCast and Tox 21 Initiatives
    • Future Challenge: Thyroid Disruption
    • BG1 Assay
  • Toxicokinetics and ADME
  • In Vitro Developments
    • Metabolism
    • Pharmacokinetics of Low Turnover Compounds
  • Organotypic Models
    • Three-dimensional Models for Skin
    • Three-dimensional Corneal System
  • Absorption Barrier Models
    • Gastrointestinal
    • Lung
    • Blood-Brain Barrier
    • Blood-Brain Barrier on a Chip
    • Real Architecture for Three-dimensional Tissue Barriers and Extracellular Matrix
  • Liver Toxicity
  • Uniqueness and Complexity of Liver.
  • Liver as a Key Driver for Three-dimensional Innovation
  • In Vitro Liver Applications
    • Liver Toxicity Testing
    • Primary Hepatocyte Use
    • Learnings From Monolayer Cultures
    • Learnings from Co-Cultures Contribution to the Development of Cytotoxicity and Three-dimensional
    • Assays
  • In Vivo Liver Function and Structure
    • Hepatocytes or Parenchymal Cells
    • Specialized Liver Endothelial Cells
    • Endothelial Cells Surround Hepatocyte Core
    • Non-Parenchymal Stellate and Kupffer Cells
  • Liver Metabolism
    • Sub-Cellular Liver Enzyme Fractions
    • Extracellular Matrix as a Driver of Differentiation
    • Toxicity Studies and Non-Parenchymal Cells Drive In Vitro Development
    • Challenges
  • Liver In Vitro Models
    • Isolated Perfused Rat Liver
    • Precision-Cut Liver Slices
    • Human Hepatocyte Isolation
    • Isolated Hepatocyte Shipping
  • Co-Cultures of Hepatocytes and Macrophages
    • Two-Chamber Systems
    • Micropatterning
  • Three-dimensional Liver Models
    • Two-dimensional Sandwich
    • Sandwich-Culture Model
    • Hydrogel Three-dimensional Scaffolds
    • Synthetic Scaffolds
    • Self-Assembled Hepatospheres
    • Hepatospheres-Derived from Cell lines vs. Primary Cells
  • Bioprinted Liver Tissue
  • Detected Hepatosphere Structures and Functionality
    • Extracellular Matrix
    • Cell-cell Contacts: Learnings from In Vitro Tox
    • Oxygen Supply
    • Co-culture with Non-parenchymal Cells In Three-dimensional Spheroids
    • Refinements to Co-culture
  • Ideal Criteria
  • Drug Resistance
  • Transporter Studies
  • Achieving Heterotypic Cell-cell Contacts
  • Summary Learnings
  • Unmet Needs and Future Drivers of Innovation
    • Regeneration
    • Achievement of Hepatocyte Expansion Still Elusive
    • Inflammation Models
    • Immune-mediated Drug-induced Liver Injury
    • High-content Imaging and Analysis
    • Stem Cell-Derived Hepatocyte Potential
  • Morphogen Signaling
  • Microfluidics Applications
    • Dielectrophoretic Forces
    • Learnings from Microfluidics
    • Self-organizing Systems
  • Multi-Donor Liver Cells
  • Kidney Toxicity Applications
  • Future Challenge: Stem-Cell Derived Kidney Cells
    • Bioprinted Kidney Tissue
  • Pancreatic Toxicology Applications
  • Cardiovascular Safety Testing of New Drug Candidates
    • Commercial Avenue
    • Collaboration with Regulators
    • In Silico: Model-Based Drug Development
    • Microelectrode Arrays Based on Impedance
    • Surrogate for Aortic Ring Assay via Bioprinted Magnetics
    • Vasodilator Activity
    • Three-dimensional Engineered Heart Tissues
  • Revenue Estimate

Chapter 9: 3D Culture Role in Stem Cells

  • Introduction
  • Early Learnings
  • Embryogenesis
    • Growth, Structure and Morphology
    • Differentiation
    • Differentiation vs. Proliferation
    • Extracellular Matrix
    • Soluble Factors
    • Mechanical Forces
    • MicroRNAs
  • Three-dimensional Stem Cell Culture Systems
    • Plate or Culture Dish
    • Spinner Flask and Rotating Wall Vessel
    • Perfusion Bioreactor and Microcarrier Systems
    • Shortcomings
  • Controlling Embryoid Body Formation
    • Forced Aggregation Cultures
    • Hanging-Drop Approach
  • Applications
    • Stem Cell Microenvironments
    • Stem Cell Markers for High-throughput Screening
    • Teratomas and the Teratoma Assay.
  • Status and Drivers
  • Fujifilm (Cellular Dynamics Inc.)
  • Breakthroughs Resulting from Stem Cells Research
  • Revenue Estimate

Chapter 10: Three-dimensional Next-Generation Outlook

  • Overview
  • Cancer
    • CDx Based on Ex Vivo 3D
    • Immuno-Oncology
  • Predictive Toxicology
    • Neuro Safety
  • Stem Cells for Neuroscience Discovery and Development
    • Example: Alzheimer's Research
    • Background: B-Amyloid Cascade Hypothesis
    • Human iPSC-derived Models
    • New 3D Model
    • Other 3D Advantages
    • Envisioned Applications
    • Other 3D Neuro Applications
  • Stem Cells for Cardiovascular Discovery
  • Stem Cells for Development of Regenerative Medicine
    • Background: Allogenic vs. Autologous
    • Induced Pluripotent Stem Cells (IPS)
  • Revenue Estimate
  • Chapter Appendix: Liver
    • Integration with "-Omics"

Chapter 11: Company Profiles

Appendix: Patent Analysis

About BCC Research

  • About BCC Research
  • BCC Library Access
  • BCC Custom Research

List of Tables

  • Summary Table Global Three-dimensional Cell Culture Market, Through 2021 ($ Millions)
  • Table 1 Tissue Types
  • Table 2 Cell Types
  • Table 3 Cell Culture Applications
  • Table 4 Leading Bioreactor Suppliers, 2017
  • Table 5 Leading Tissue Products and Suppliers, October 2016
  • Table 6 Global Market for Three-dimensional Bioreactors and Microcarriers, Through 2021 ($ Millions)
  • Table 7 High-Content Screening Suppliers and Key Attributes, January 2017
  • Table 8 Label-Free Technologies and Suppliers, January 2017
  • Table 9 Automated Patch Clamping Companies and Technologies, January 2017
  • Table 10 Leading Cell Line Suppliers, January 2017
  • Table 11 Leading Primary Cell Suppliers, January 2017
  • Table 12 Leading Stem Cell Suppliers, January 2017
  • Table 13 Typical Assay Endpoints and Tests
  • Table 14 Organ-On-Chip Industry
  • Table 15 Bioprinting Instrument Technologies
  • Table 16 Maintaining Cell Viability During Printing
  • Table 17 Bioprinting Instrument Industry
  • Table 18 Bioink Components
  • Table 19 Bioink Types
  • Table 20 Matrix Bioink Hydrogel Classes
  • Table 21 Matrix Bioink Selection Criteria
  • Table 22 Selected Bioink Companies
  • Table 23 In Vitro Testing in Cosmetics
  • Table 24 Bioprinting Industry Alliances in Cosmetics, 2015
  • Table 25 Printed Tissue and Organs: Commercialization Timeframe
  • Table 26 Tissue/Organ Complexity
  • Table 27 Skin Substitute Products and Market Focus
  • Table 28 U.S. Regulatory Considerations
  • Table 29 Number of United States Organ Transplants, January-June 2016
  • Table 30 Bioprinting Industry Acquisitions and Strategic Alliances, January 2014-February 2016
  • Table 31 Leading Reagent, Media and Microplate Suppliers, January 2017
  • Table 32 Three-dimensional Technology Product Market, Through 2021 ($ Millions)
  • Table 33 Common Three-dimensional Assays
  • Table 34 Three-dimensional Tumor Models Developed for Drug Discovery, June 2017
  • Table 35 Summary of EV3D Benefits/Advantages
  • Table 36 Global Market for Three-dimensional Culture Used in Cancer Drug Development, Through 2021 ($ Millions)
  • Table 37 In Vitro Testing in Cosmetics
  • Table 38 Alliances Between Bioprinting and Cosmetics Companies, 2015
  • Table 39 In Vitro and In Vivo Assays in the Tier 1 Screening Battery, January 2014
  • Table 40 Global Market for Three-dimensional Cultures Used in Predictive Tox Applications, Through 2021 ($ Millions)
  • Table 41 Global Market for Three-dimensional Cultures Used in Stem Cell Research Applications, Through 2021 ($ Millions)
  • Table 42 New Applications That Have Emerged Since the 2015 Report
  • Table 43 Global Market for Next-Generation 3D Applications, Through 2021 ($ Millions)
  • Table 44 Patents Assigned in 3D Cell Culture, 2009-2017

List of Figures

  • Summary Figure Global Three-dimensional Cell Culture Market, 2015-2021 ($ Millions)
  • Figure 1 Technology Maturity
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