The worldwide market for sequencing products will grow from an estimated $1.3 billion in 2010 to more than $3.3 billion by 2015, a compound annual growth rate (CAGR) of 20.5% over the next 5 years.
Life-science research and drug discovery and development applications represent the two largest markets for DNA sequencing revenues, accounting for an estimated $920.1 million in 2010. These markets are forecast to grow at a compound annual growth rate (CAGR) of 13% to reach nearly $1.7 billion in 2015.
Emerging applications, including personal genomics and clinical diagnostics, are forecast to account for $541.4 million by the year 2015, an increase from $15.5 million in 2010 representing a 103.5% compound annual growth rate (CAGR).

STUDY GOALS AND OBJECTIVES

BCC' s goal for this study is to determine the status of current and newer generation DNA (deoxyribonucleic acid) sequencing technologies, products and services and to assess their worldwide growth potential over a 5-year period from 2010 to 2015. Our particular interest is to characterize and quantify the DNA sequencing products market by application, technology, analysis type, geography, and end user. Sequencing applications market segments that will provide substantial future growth opportunities for next-generation DNA sequencing companies include research, drug discovery and development, bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. Applications providing growth opportunities for genomics suppliers include sequence capture and bioinformatics.

Our main objective is to present a comprehensive discussion of DNA sequencing technologies; industry structure; key applications; major sequencing initiatives; global markets; intellectual property (IP) and patenting status; and sequencing companies. This discussion will assist life-science companies in strategic planning to meet the challenges and opportunities of this dynamic industry.

REASONS FOR DOING THE STUDY

The Human Genome Project (HGP) moved DNA sequencing technology to the forefront of life-science research as a genetic analysis tool. The HGP relied heavily on Sanger sequencing by capillary electrophoresis to decipher the DNA sequence of the bases in the human genome. A significant outcome of the HGP was improvements in the efficiency and costs of DNA sequencing. During this time period, the DNA sequencing industry consolidated, resulting in one dominant company, Applied Biosystems.

Beginning in 2005, new DNA sequencing technologies have emerged that are radically changing the structure of the industry and opening up exciting new market applications. Contributing to the rise of these new sequencing technologies are advances in nanotechnology, microfluidics, imaging, enzymology, and bioinformatics. Based on these market and technology dynamics, it is timely to examine the future DNA sequencing markets.

Ongoing discoveries in nanotechnology, bioinformatics, microfluidics, imaging, enzymology, and bioinformatics are revolutionizing many life-science fields, and providing novel platforms for next-generation DNA sequencing. At the same time this is occurring, there is a growing market demand for analysis of the genomes of many species and cancers and for understanding the role of genetic variation among individuals in disease. The genetic analysis industry seeks to meet these needs with tools such as microarrays, real-time polymerase chain reaction (RT-PCR), and DNA sequencing instruments.

Next-generation sequencing has created new opportunities to compete with traditional genetic analysis tools, and this report examines this trend and its significance for companies supplying DNA sequencing products and services.

Next-generation, and follow-on, third-generation DNA sequencing technologies will continue to change the dynamics of the DNA sequencing industry and create novel market opportunities. This report analyzes these trends and their impact on the future markets for DNA sequencing technologies.

Given the evolving nature of this industry, it is particularly timely to gain an understanding of these technological and competitive forces and the impact on the genetic analysis markets.

SCOPE OF REPORT

The study scope includes DNA sequencing technologies likely to be commercialized within the next 5 years. Sanger, next-generation, and third-generation technologies are included. Each technology is analyzed to determine its market status, impact on future market segments, and forecast growth from 2010 through 2015. Advantages and limitations of each technology together with market driving forces are discussed.

BCC examines the sequencing industry structure, strategic industry alliances and acquisitions, and sequencing patents. The strategies of the main sequencing companies are discussed. The markets for sequencing applications, including de novo whole-genome sequencing, resequencing, ChipSeq, MethylSeq, and RNASeq, are analyzed.

METHODOLOGY

BCC surveyed key users and producers in each of the market applications that will be commercially important during the next 5 years: research, drug discovery and development, forensics and human identification (ID), bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. Based on our industry discussions and market analysis, we project the future applications of sequencing platforms and forecast sales revenues for 2010 through 2015.

The sequencing market is analyzed by technology, product type, application, customer, analysis type, geography, and genome type, with forecasts of market demand from 2010 through 2015. We analyze which applications and analyses will be important to the future of DNA sequencing, and the customer groups that will be consumers of the technologies. We also analyze the impact of other genetic analysis technologies like microarrays on the growth of sequencing.

INFORMATION SOURCES

BCC surveyed leading DNA sequencing, biotechnology, and nanotechnology companies as well as core sequencing facilities and laboratories to obtain data for this study. Included were research tools, drug, biotechnology and nanotechnology firms, and leading life-science research institutions. We also spoke with leading industry thinkers. In addition, we compiled data from secondary sources, including industry, trade, and government.

ANALYST CREDENTIALS

The author, John Bergin, has written previous BCC Research biotechnology reports, titled Epigenomics: Emerging Opportunities in Biomarkers, Diagnostics and Therapeutics; Global Biochip Markets: Microarrays and Lab-on-a-Chip; RNA Interference in the Post-Genomics Era: Markets and Technologies; Synthetic Biology: Emerging Global Markets; Biologic Imaging Reagents: Technologies and Global Markets. Mr. Bergin has held business development, sales, and marketing positions with a Fortune 500 advanced materials company as well as executive management positions with a nanotechnology company. Mr. Bergin holds the following degrees: B.S. Chemistry, M.S. Biotechnology, and Masters of Business Administration.

DNA Sequencing: Emerging Technologies and Applications

Chapter- 1: INTRODUCTION -- Complimentary

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC REPORTS
ANALYST CREDENTIALS
BCC ONLINE SERVICES
DISCLAIMER

Chapter-2: EXECUTIVE SUMMARY

SUMMARY TABLE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)
SUMMARY FIGURE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, 2009-2015 ($ MILLIONS)
EXECUTIVE SUMMARY (CONTINUED)

Chapter-3: OVERVIEW

INTRODUCTION
MARKET POTENTIAL OF DNA SEQUENCING PRODUCTS
SEQUENCING INDUSTRY GROWTH DRIVING FORCES
SEQUENCING INDUSTRY GROWTH ... (CONTINUED)
SEQUENCING PRODUCTS
SEQUENCING INSTRUMENTS
SEQUENCING CONSUMABLES
SEQUENCING PRODUCT LIFE CYCLE STATUS
COMMERCIAL STATUS
SEQUENCING INDUSTRY
SEQUENCING INDUSTRY (CONTINUED)

Chapter-4: DNA SEQUENCING TECHNOLOGIES

GENETIC ANALYSIS
GENETIC ANALYSIS (CONTINUED)
HISTORY OF DNA SEQUENCING
HISTORY OF DNA SEQUENCING (CONTINUED)
HISTORY OF DNA SEQUENCING (CONTINUED)
HISTORY OF DNA SEQUENCING (CONTINUED)
OVERVIEW OF SEQUENCING TECHNOLOGIES
SANGER SEQUENCING
SANGER SEQUENCING TECHNOLOGY
SANGER SEQUENCING COSTS
LIMITATIONS OF SANGER SEQUENCING
TECHNOLOGY DEVELOPMENTS IN SANGER SEQUENCING
NEXT-GENERATION SEQUENCING TECHNOLOGIES
INTRODUCTION
NEXT-GENERATION SEQUENCING WORKFLOW
Next-generation Sequencing ... (Continued)
SEQUENCING BY SYNTHESIS WITH REVERSIBLE TERMINATORS
PYROSEQUENCING
SEQUENCING BY LIGATION
Sample Preparation
Sequencing Reaction
Cycle 1
Cycle 2
Cycles 3 to 5
Decoding
THIRD-GENERATION SEQUENCING
Single-molecule Sequencing by Synthesis
Nanopore Sequencing
Nanopore Sequencing (Continued)
Nanopore Sequencing (Continued)
Nanopore Sequencing (Continued)
SEQUENCING TECHNOLOGY PLATFORMS COMPARED
Sequencing Technology ... (Continued)
SEQUENCING PRODUCT LIFE CYCLE
SEQUENCING INSTRUMENT CUMULATIVE INSTALLED BASE
SEQUENCE READ LENGTH
SEQUENCER PERFORMANCE SPACE
END-USER SWITCHING
PAIRED-END READS
BARCODING
DNA POLYMERASES
SEQUENCING BIOINFORMATICS
TECHNOLOGY CHALLENGES FOR NEXT-GENERATION PLATFORMS
Technology Challenges ... (Continued)

Chapter-5: DNA SEQUENCING APPLICATIONS

INTRODUCTION
RESEARCH AND DRUG DISCOVERY APPLICATIONS
INTRODUCTION
Introduction (Continued)
DE NOVO SEQUENCING
De Novo Human Sequencing
De Novo Microbial Sequencing
RESEQUENCING
Whole Genome Resequencing (Genome-wide Association Studies or Loci Discovery)
Targeted Resequencing
SEQ-BASED METHODS
Chromatin Immunoprecipitation Applications
DNase-seq
Gene Expression Analysis
MethylSeq
DNA Mutation Studies
Complementary Sequencing and Microarray Platforms Drive Market Growth
DIAGNOSTICS AND DRUG DISCOVERY
DIAGNOSTICS AND DRUG DISCOVERY (CONTINUED)
DIAGNOSTICS AND DRUG DISCOVERY (CONTINUED)
PERSONAL GENOMICS

Chapter-6: DNA SEQUENCING INITIATIVES

INTRODUCTION
NHGRI $1,000 GENOME PROJECT FUNDING
SEQUENCING-RELATED GENOMICS PROJECTS OVERVIEW AND STATUS
GENOME SEQUENCING PROJECTS
Functional Genomics in Norway (FUGE) II
Personal Genome Project
Archon X Prize in Genomics
Genomes 10K Project
1,000 Plant and Animal Reference Project
MEDICAL SEQUENCING PROJECTS
Mapped Autosomal Mendelian Disorders
Allelic Spectrum in Common Disease Program
Clinseq Project
CANCER SEQUENCING PROJECTS
Cancer Genome Project
Tumor Sequencing Project (TSP)
The Cancer Genome Atlas
MICROBIAL SEQUENCING PROJECTS
Human Microbiome Project
Microbial Genome Sequencing Project
Marine Microbial Genome Sequencing Project
Fungal Genome Initiative
Pathogen Sequencing Program
Genomic Encyclopedia of Bacteria and Archaea (GEBA)
Metagenomics of the Human Intestinal Tract (MetaHIT)
Gut Microbiome Initiative
10,000 Microbial Genomes Project
GENOME VARIATION PROJECTS
Encyclopedia of DNA Elements (ENCODE)
1,000 Genomes Project
1,000 Plant Genomes Project
Resequencing Technology Program
Human Genome Structural Variation Project
Yanhuang Project
AGRICULTURAL GENOMICS
National Plant Genome Initiative
EPIGENOMICS SEQUENCING PROJECTS
EUROPE
UNITED STATES
United States (Continued)
ASIA
IMPACT OF SEQUENCING PROJECTS

Chapter-7: DNA SEQUENCING INDUSTRY STRUCTURE

INDUSTRY STRUCTURE ANALYSIS
INDUSTRY STRUCTURE ANALYSIS (CONTINUED)
THE ROLE OF EARLY ADAPTORS
SEQUENCING INSTRUMENT COMPETITOR POSITIONING
Sequencing Instrument ... (Continued)
Sequencing Instrument ... (Continued)
SEQUENCING SAMPLE PREPARATION INDUSTRY
Sequencing Sample ... (Continued)
SEQUENCING BIOINFORMATICS INDUSTRY
SEQUENCING SERVICES INDUSTRY
SEQUENCING INSTRUMENTS COMPETITOR MARKET SHARES
Sequencing Instruments ... (Continued)
INDUSTRY ACQUISITIONS AND STRATEGIC ALLIANCES
Industry Acquisitions ... (Continued)
Industry Acquisitions ... (Continued)
Industry Acquisitions ... (Continued)
SEQUENCING REAGENTS SUPPLY ALLIANCES
PERSONAL GENOMICS INDUSTRY DYNAMICS
Personal Genomics ... (Continued)
DNA SEQUENCING END USERS
Major Sequencing Centers
Major Sequencing Centers (Continued)
Large Core Sequencing Centers
Small to Mid-size Laboratories
Sequencing Service Laboratories
Sequencing Service ... (Continued)

Chapter-8: DNA SEQUENCING MARKETS

GROWTH DRIVING FORCES
GROWTH DRIVING FORCES (CONTINUED)
GROWTH DRIVING FORCES (CONTINUED)
GENETIC ANALYSIS MARKETS
GENETIC ANALYSIS MARKETS (CONTINUED)
DNA SEQUENCING PRODUCTS MARKETS
DNA SEQUENCING MARKETS BY PRODUCT TYPE
DNA Sequencing ... (Continued)
DNA SEQUENCING MARKETS BY SANGER AND NEXT-GENERATION FORMATS
DNA SEQUENCING MARKETS BY END USER
DNA Sequencing ... (Continued)
DNA SEQUENCING MARKETS BY TECHNOLOGY
DNA SEQUENCING MARKETS BY END-USER APPLICATION
Research and Drug Discovery and Development
Forensic and Human ID
Bacterial Genomics
Agricultural Genomics
Clinical Diagnostics
Personal Genomics
Personal Genomics (Continued)
Other Applications
Other Applications (Continued)
DNA SEQUENCING MARKETS BY GENOME TYPE
DNA Sequencing Markets (Continued)
DNA SEQUENCING MARKETS BY ANALYSIS TYPE
DNA SEQUENCING MARKETS BY GEOGRAPHY
DNA Sequencing Markets ... (Continued)

Chapter-9: DNA SEQUENCING PATENT STATUS

RECENT PATENT ACTIVITY IN NEXT-GENERATION DNA SEQUENCING
Sequencing by Synthesis
Single-molecule Sequencing
Nanopore Sequencing
Polony Sequencing
Nucleotide Modifications and Analogs
DNA Polymerases
Paired-end Inventions
Other Methods
PATENT POSITION OF SEQUENCING COMPETITORS
TECHNOLOGY DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS
GEOGRAPHICAL DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS
SEQUENCING LITIGATION STATUS
SEQUENCING LITIGATION STATUS (CONTINUED)
INTELLECTUAL PROPERTY POSITION OF SELECTED SEQUENCING COMPANIES
LIFE TECHNOLOGIES
LI-COR BIOSCIENCES
HELICOS BIOSCIENCES
ILLUMINA
INTELLIGENT BIO-SYSTEMS
PACIFIC BIOSCIENCES

Chapter-10: COMPANY PROFILES

23ANDME
AFFOMIX CORPORATION
AFFYMETRIX, INC.
AGILENT TECHNOLOGIES, INC.
AGILENT TECHNOLOGIES, INC. (CONTINUED)
ARTEMIS HEALTH, INC.
BASE4INNOVATION, LTD.
BECKMAN COULTER
BECKMAN COULTER (CONTINUED)
BIO.LOGIS CENTER FOR HUMAN GENETICS
BIONANOMATRIX, INC.
BIOTIQUE SYSTEMS INC.
CALIPER LIFE SCIENCES
CALIPER LIFE SCIENCES (CONTINUED)
CALIPER LIFE SCIENCES (CONTINUED)
COLLABRX, INC.
COMPLETE GENOMICS, INC.
CONEXIO GENOMICS
CORRELAGEN DIAGNOSTICS, INC.
DANAHER MOTION
DECODEME
DELTADOT, LTD.
DNANEXUS, INC.
DNA STAR, INC.
ELECTRONIC BIOSCIENCES
EUROFINS MEDIGENOMIX GMBH
EXPRESSION ANALYSIS, INC.
FASTERIS SA
FEBIT BIOTECH GMBH
FIREBIRD BIOMOLECULAR SCIENCES, LLC
FLUIDIGM CORPORATION
FLUIDIGM CORPORATION (CONTINUED)
FOUNDATION FOR APPLIED MOLECULAR EVOLUTION
GATC BIOTECH AG
GE HEALTHCARE
GENEDATA AG
GENOME DIAGNOSTICS B.V
GENOMEQUEST, INC.
GENOMATIX SOFTWARE, INC.
GENOVOXX GMBH
GEOSPIZA, INC.
HALCYON MOLECULAR
HELICOS BIOSCIENCES CORPORATION
INTERNATIONAL BUSINESS MACHINES CORP.
ILLUMINA, INC.
ILLUMINA, INC. (CONTINUED)
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
INTELLIGENT BIO-SYSTEMS
INTERNA GENOMICS BV
ION TORRENT SYSTEMS
IP GENESIS INC.
ISENTIO AS
KNOME, INC.
LASERGEN, INC.
LI-COR BIOSCIENCES
LIFE TECHNOLOGIES, INC.
LIFE TECHNOLOGIES, INC. (CONTINUED)
LIFE TECHNOLOGIES, INC. (CONTINUED)
LIFECODEXX
LIGHTSPEED GENOMICS
LINGVITAE AS
MICROCHIP BIOTECHNOLOGIES, INC.
MWG BIOTECH AG
MYCROARRAY.COM
NABSYS, INC.
NAVIGENICS
NETWORK BIOSYSTEMS
NEWGENE, LTD.
NUGEN TECHNOLOGIES, INC.
OLINK GENOMICS AB
OPGEN, INC.
OXFORD NANOPORE TECHNOLOGIES
PACIFIC BIOSCIENCES
PACIFIC BIOSCIENCES (CONTINUED)
POPULATION GENETICS TECHNOLOGIES, LTD.
QUANTALIFE, INC.
RAINDANCE TECHNOLOGIES, INC.
REAL TIME GENOMICS
REVEO INC.
ROCHE LIFE SCIENCES
ROCHE LIFE SCIENCES (CONTINUED)
ROCHE LIFE SCIENCES (CONTINUED)
SEIRAD, INC.
SEQUENOM, INC.
SEQUENOM, INC. (CONTINUED)
SEQUENOM, INC. (CONTINUED)
SEQWRIGHT
SHIMADZU SCIENTIFIC INSTRUMENTS
SMARTGENE
SOURCE BIOSCIENCES, PLC.
SORENSON GENOMICS
U.S. GENOMICS
VISIGEN BIOTECHNOLOGIES, INC.
X-PRIZE FOUNDATION
ZS GENETICS
ZS GENETICS (CONTINUED)
ZS GENETICS (CONTINUED)

Press Release

DNA定序產品：預估全球市場在2015年之前將以CAGR20.5％擴大

2010年08月11日

Global Information, Inc.已開始銷售美國市場調查公司BCC Research所發行的報告書「DNA Sequencing: Emerging Technologies and Applications (DNA定序：新技術與應用)」

2005年以後，重新登場的DNA定序技術橫掃同業界，使其構造發生戲劇性的變化。因此，應用新市場的機會越發擴展。預測臨床診斷與個人基因組學(personal-genomics)等新的應用在2015年之前將創出5億4,140萬美元。與2010年的1,550萬美元比較，年複利成長率(CAGR)為103.5％。BCC Research陳述『鑑於該市場與技術動向，現在正是檢證將來DNA定序市場的時機』。

依據該報告，預測全球的定序產品市場將從2010年的13億美元到2015年之前成長為超過33億美元的規模，其間 5年的CAGR為20.5％。該報告的主要目的為調查現行及下一代的DNA（脫氧核糖核酸）定序技術、服務、與產品的動向。CC Research的分析者陳述「我們著眼於DNA定序技術與業界構造、主要的應用領域、及定序的處理，且總括性歸納全球市場動向、智慧財產、專利動向、進入企業的概要等。」。此外，亦聚焦於2010～2015年5年間整體成長的可能性，尤其關注各用途、技術、分析類型、地域、終端用戶的DNA定序產品之特性與定量評價。

在定序的應用中，對下一代的DNA定序企業而言，預估將來會大幅成長的市場區塊有創藥、新藥開發、細菌生染色體組、研究、臨床診斷藥、個人基因組學(personal-genomics)、農業用基因組等。

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DNA定序：新技術與應用

DNA Sequencing: Emerging Technologies and Applications