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Tuesday, March 25

7:00am Registration (Open until 5:30pm)

8:00 Plenary Keynote Introduction
Harry Glorikian, Managing Partner, Scientia Advisors

8:15 Diagnosing the Disease: Disruptive Innovation in Healthcare
Clayton M. Christensen, DBA, Robert and Jane Cizik Professor of Business Administration, Harvard Business School
In the absence of the ability to precisely define a disease, the care of patients is best undertaken by highly skilled professionals, whose intuition is based on deep expe-rience. This describes the history of health care, and we call this the practice of intuitive medicine. Molecular biology holds the promise of transforming medical practice into a new phase that we call precision medicine. It promises to dramatically reduce cost and increase the predictable effectiveness of therapy.

9:45 Coffee Break

10:15am �E1:15pm Morning Pre-Conference Short Course*

(SC4) THE EPIGENETICS STEM CELL SIGNATURE Sponsored by Aviva Systems Biology Speakers: Mark E. Levenstein, Ph.D., Research Scientist, WiCell Research Institute Jeffrey Falk, Ph.D., Director of Technology Applications, Molecular Biology, Aviva Systems Biology Joseph C. Wu, M.D., Ph.D., Instructor, Cardiovascular Medicine, Molecular Imaging Program, Stanford University School of Medicine (tentative) Yue Xiong, Ph.D., Professor, Biochemistry, University of North Carolina at Chapel Hill Key Learning Points: General Mechanisms of Epigenetic Regulation Identification of Key Pathways and Biomarkers Involved in Human Stem Cell Differentiation by Decoding Promoter Methylation Patterns in Human ES Cells Effects of Epigenetic Modulation on Reporter Gene Expression:Implications for Stem Cell Imaging Control of Lung and Mammary Stem and Progenitor Cell Cycle *Separate Registration Required

1:15 Lunch on Your Own

2:30 - 5:30 Afternoon Pre-Conference Short Course*

(SC7) CANCER STEM CELLS Techniques for isolating cancer stem cells Methods to characterize cancer stem cells Approaches for developing anti-cancer stem cells compounds Characterization and Targeting of Leukemia Stem Cells Craig T. Jordan, Ph.D., Director, Hematologic Malignancies Translational Research Program, James P. Wilmot Cancer Center and Associate Professor of Medicine, University of Rochester School of Medicine �Cancer Stem Cells�Ein Solid Epithelial Tumors: Working Definition and Implications for Patient Prognosis Piero Dalerba, M.D., Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Identification of Stem Like Cells in Bone Sarcomas C. Parker Gibbs, M.D., Associate Professor, Orthopaedics, University of Florida Characterizing Brain Tumor Stem Cells in Man and Mouse Peter B. Dirks, Ph.D., Scientist & Principal Investigator, Neurosurgery, Hospital for Sick Children *Separate Registration Required