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為了機能性篩選的RNAi
RNA干涉(RNAi)廣泛作為特別指定潛在性藥劑標的與確認療法、探求未知細胞路徑、以及實施全生染色體組機能篩選的篩選工具。此篩選用來開發低分子干涉RNA(siRNA)和小髮夾型核醣核酸（short hairpin RNA; shRNA），現在相當穩固且感受性高，已成為可靠性高、高處理的工具。此會議是針對做各種應用之體外及體內RNAi篩選的活用、適當的模式系統和試劑的選擇、RNAi delivery、Off-Target effect、解決是偽陽性或陰性問題、改善品質管理和數據分析等進行討論的活動。

11月3日 星期四

Assay design和設定

1:30 pm Chairperson’s Remarks

Christophe Echeverri, Ph.D., CEO & CSO, Cenix BioScience GmbH

1:40 Talk Title to be Announced

Alex Gaither, Ph.D., Research Investigator II, Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research

2:10 Screening Approaches Towards Identifying Genes Associated with DNA Re-Replication in Cancer Cells

Scott Martin, Ph.D., Team Leader, RNAi Screening, NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, NIH

The NIH Chemical Genomics Center has established an RNAi screening facility that performs screens in collaboration with investigators throughout the NIH intramural community. An initial genome-wide campaign involved screening for genes associated with aberrant DNA replication. Screening was conducted using libraries comprised of both pooled and individual siRNAs. Combining these approaches led to a thorough examination of genes associated with DNA replication and served as a way to compare the value of both platforms.

2:40 RNAi Screening Comes of Age: For the Love of My Target

Hakim Djaballah, Ph.D., Director, HTS Core Facility, Memorial Sloan Kettering Cancer Center

RNAi screening has offered the premise of performing several thousand simultaneous knockdowns leading to the discovery and validation of existing and novel targets. Several years on, has the technology matured enough to keep up with its premise?

3:10 Networking Refreshment Break in the Exhibit Hall with Poster Viewing

3:45 Speaker to be Announced

Sponsored by
4:15 Sponsored Presentation
Speaker to be Announced

5:45 End of Day

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