最新生物資訊科學：策略、商業模式、未來趨勢

Abstract

The life science informatics marketplace--known as bioinformatics--is set to expand as high-tech companies infiltrate this arena and biopharmaceutical companies incorporate key informatic solutions into their business strategies. TriMark Publications believes that many of the segments of bioinformatics described in this report offer an unusual opportunity for accelerated expansion within the coming years. This study is arranged to provide an overview of bioinformatics market segments and offer evidence that these segments are poised for significant future growth. Each segment is accompanied by analysis and forecasts by product type and application. This analysis surveys the bioinformatics market and the latest information regarding emerging new products and industry trends. The study will quantify and qualify the bioinformatics market segments as an area of research, product development and investment. Forecasts of the bioinformatics market and an analysis of products in the worldwide information-processing market will provide a basis for understanding the significance of past developments and future possibilities within this market category.

TABLE OF CONTENTS

1.0 Overview

1.1 Statement of Report

1.2 Objectives of This Report

1.3 Scope of This Report

1.4 Methodology

2.0 Introduction

2.1 Global Bioinformatics Products Industry

2.2.1 Bioinformatics and the Internet

2.3 Company Evaluation Overview

2.4 Market Outlook

2.4.1 Competitive Structure

2.5 Applications of Bioinformatics

2.5.1 Healthcare

2.5.2.1 R&D Applications Growth

2.5.2.2 Allocation of Research and Development

2.5.2.3 Drug Discovery and Informatics

2.5.2.4 Collaborative Agreements

2.5.2.5 Traditional Drug Discovery Process

2.6 The Human Genome Project (HGP)

2.6.1 Goals of the Human Genome Project

2.6.2 Benefits of the Human Genome Project

2.7 Barriers to Entry

2.8 Proteomincs and Databases

2.8.1 Protein Database Standards

2.8.2 Future Trends

3.0 The U.S. Bioinformatics Market

3.1 Overview

3.2 Market Revenue and Growth Forecasts

3.3 Market Drivers

4.0 Genomics

4.1 The Biotechology Industry

4.2 The Development of a Genomics Market

4.2.1 Market Drivers

4.2.2 Market Restraints

4.2.3 Market Size and Growth Projections

4.2.4 The U.S. Genomics Market

4.3 Biochips and Microarrays

4.3.1 Key Challenges

4.3.2 Free Ware

4.3.3 New Tools

4.4 Bioinformatics

4.5 Disease Targets

4.6 Functional Genomics

4.7 Gene Sequencing

4.9 Comparative Genomics

4.10 Genome Database Arrays

4.11 High Throughput Genomics

4.11.1 High-throughput Technology

4.11.2 Lab on a Chip

4.11.3 Key Benefits of LabChip Systems

4.12 Pharmacogenomics

4.13 DNA Analysis Arrays

4.14 Proteomics

4.15 Sequencing

4.16 Single Nucleotide Polymorphism (SNP)

4.17 Structural Genomics

4.18 Photolithography

4.19 Instrumentation

5.0 The Bioinformatics Industry

5.1 Definition and Role of Bioinformatics

5.1.1 Bioinformatics Sector Overview

5.1.2 The Future Status of Bioinformatics

5.2 Types of Data and Bioinformatics Applications

5.2.1 Validated Core Modeling Technology

5.2.2 Broad Applicability

5.2.3 Data Management Compliant with Industry Standards

5.2.4 Open Architecture

5.2.5 Ease of Use

5.2.6 Increased Access

5.3 Functions of Informatics Software

5.3.1 Data Management

5.3.2 Data Transformation

5.3.3 Data Collaboration

5.3.4 Interface for Online Data Sources

5.4 Target Markets for Informatics Software

5.5 Steps Involved in Bringing a Drug to Market

5.6 Costs Incurred in Developing a New Drug

5.7 Industry Drivers and Challenges

5.8 Industry Risks

5.9 Products of Bioinformatics

5.10 Bioinformatics Processes

5.11 Informatics Tools and Functionalities

5.11.1 Sequence to Structure

5.11.2 Lead Identification and Optimization

5.11.3 Development and Formulation

5.11.4 Improving Materials and Processes

5.11.5 Other Materials Based Industries

5.12 Role of Bioinformatics in the Biotechnology Value Chain

5.13 Bioinformatics Market Segments

5.13.1 Database

5.13.2 Hardware

5.13.3 Software

5.13.4 Bioinformatics Services

5.14 Bioinformatics Market Size

5.14.1 Sales and R&D

5.14.2 IT Budget

5.14.3 Projected Bioinformatics Market Size

5.14.4 Bioinformatics Market Break-Up

5.15 Bioinformatics Business Models

5.15.1 Changing Business Models

5.15.2 Competition for Pure Play Informatics Companies

5.15.3 Non-Profit Organizations

5.15.4 In-House Bioinformatics Solutions

5.15.5 Large IT Companies

5.16 Bioinformatics Target Disciplines

5.16.1Comparative Genomics

5.16.2 Pharmacogenomics

5.16.3 Functional Genomics

5.16.4 Proteomics

5.16.5 Structural Genomics

5.16.6 Image Informatics

5.16.7 Clinical Trial Informatics

5.16.8 Cheminformatics

5.17 Bioinformatics Architecture

5.18 Bioinformatics Applications

5.18.1 Data Search Tools

5.18.2 Data Visualizations Tools

5.18.3 Data Mining and Clustering

5.18.4 Enterprize Solutions

5.18.5 Data Warehousing

5.19 Evaluation of Bioinformatics Solutions

5.19.1 Requirements of Study

5.19.2 Shortlisting the Options

5.19.3 Scoring Patterns

5.19.4 Performance

5.19.5 Data Storage

5.19.6 Data Management in Drug Discovery

5.19.7 Key Issues in Bioinformatics Data Storage

5.20 Convergence of Industries

5.21 Proteins as a Driver

5.22 Biotech Alliances

5.23 Current Bioinformatics Research

5.24 New Bioinformatics Modeling Algorithms

5.24.1 Data Integration

5.24.2 Constraint-Based Modeling

5.24.2.1 Karyote

5.24.2.2 Ortoleva

5.24.3 Modeling versus Computation

5.24.4 3D Modeling

5.25 Patenting Bioinformatics Algorithms

6.0 Product Development and Launches

7.0 Global Market Perspective

7.1 Corporate Profiles

INDEX OF FIGURES

• Figure 1: Global Biotechnology Industry
• Figure 2: Informatics Applications along the Drug Discovery Value Chain
• Figure 3: Bioinformatics Software Functionalities
• Figure 4: Growth of GenBank, 1982-2002
• Figure 5: EMBL Database Growth, 1991-2003
• Figure 6: Steps Involved in Bringing a Drug to Market
• Figure 7: Break-Up of the Total Costs in Developing a New Drug
• Figure 8: Role of Bioinformatics in the Biotechnology Value Chain
• Figure 9: Worldwide Projected Sales and R&D Expenditure, 2000-2010
• Figure 10: Worldwide Projected Growth in IT Budget, 2000-2010
• Figure 11: Worldwide Projected Bioinformatics Market, 2000-2010
• Figure 12: Worldwide Bioinformatics Market Break-Up, 2000-2010
• Figure 13: Steps of a Proteomics Experiment
• Figure 14: Bioinformatics Architecture

INDEX OF TABLES

• Table 1: Leading Biotechnology Companies
• Table 2: Pharmaceutical R&D Spending by Type, Growth Rate and Expenditure, 1980-2001
• Table 3: Pharmaceutical R&D Expenditures by World Region, 1990-2003
• Table 4: Total of Domestic U.S. R&D and R&D Abroad, Ethical Pharmaceuticals, Research-Based Pharmaceutical Companies, 1980-2003
• Table 5: Global Pharmaceutical R&D Expenditures, 1993-2004
• Table 6: R&D Spending at Top Pharmaceutical Companies: 2002 versus 2003
• Table 7: SIB Informatics Database
• Table 8: The U.S. Biotechnology Industry Size & Revenue, 1995-2001
• Table 9: Top Dozen U.S. Biotechnology Companies by Market Capitalization
• Table 10: Top Five U.S. Biotechnology Companies in Genomic Segment
• Table 11: Top Six U.S. Biotechnology Companies in Pharma Segment
• Table 12: Global Biotechnology Industry Major Segments, 2004
• Table 13: Genomics Sector Market Size, 2001-2010
• Table 14: The Biochip Array Market, 2000-2010
• Table 15: Selected Competitors in the Biochip Markets
• Table 16: Biochip Microarray Products
• Table 17: Microarrays (DNA Chips) Market, 2000-2010
• Table 18: Bioinformatics Tools
• Table 19: The Worldwide Market for Bioinformatics, 2000-2008
• Table 20: Functional Genomics Companies Building Advanced Integrated Platforms and Substantial Databases
• Table 21: Companies Using New Genomic Tools
• Table 22: Detection Technology Companies for Genomics
• Table 23: Spotting Technology Suppliers
• Table 24: On-Chip (in-situ) Synthesis Market Segment
• Table 25: Non-DNA Based Chip Suppliers
• Table 26: Robotics or “Lab-on-a-Chip” Market Sector
• Table 27: Key High Throughput and Systemic Approaches for Genomic Analysis
• Table 28: Total Biochip Market, 2002-2010
• Table 29: Pharmacogenomics Segment Players
• Table 30: The World Wide Market for Pharmacogenomics, 2000-2008
• Table 31: Competitors in the SNP Genotyping Segment
• Table 32: Scanning and Detection Technology Suppliers
• Table 33: Data Source and Bioinformatic Investigations
• Table 34: Companies in the Bioinformatics Software and Software-Related Services Sector
• Table 35: Drivers and Challenges of the Bioinformatics Industry
• Table 36: Bioinformatics Courses on Offer
• Table 37: Web-Based Bioinformatics Courses on Offer
• Table 38: Bioinformatics Activities, Sub-Activities and Key Players
• Table 39: Alliances between IT/Telecom and Biotechnology Firms
• Table 40: Types of Intellectual Property Protection for Bioinformatics Tools
• Table 41: Bioinformatics Market Size, 2000-2010