藥品研發技術之進歩

Abstract

Developing High Throughput Technologies for Protein Analysis

As most drug targets are proteins, there is a vested interest in high throughput technologies for proteins. Proteins are 3D fragile structures unlike DNA chips, so concept of surface chemistry and density requirements need to be evaluated before plunging into chip manufacturing.

Demand for Tools which Promise to Hasten the Drug Discovery Process

The pharmaceutical industry is now under tremendous pressure from dwindling drug pipelines, no recent launch of potential blockbuster drugs and expiry of patents for the present blockbuster drugs. Pharmaceutical companies are now looking for tools that would hasten the drug discovery process and improve productivity. Any tool or technology that has been found to have these benefits is being actively pursued.

Automation Not Living Up to the Expectations

Technologies such as HTS as well as automation of the drug discovery process have not lead to any significant increase in the drug pipelines. The assumption of increasing the probability of a successful drug discovery by screening more number of compounds has not yielded results. So the goal is to make these technologies yield maximum output.

Table of Contents

1. Executive Summary

• 1. Introduction
  • 1. Introduction to Drug Discovery
  • 2. Drug Discovery Process
• 2. Scope and Methodology
  • 1. Scope
  • 2. Methodology

2. Technology and Application Viewpoint

• 1. Technology and Application Analysis
  • 1. Technology Primer
  • 2. Latest Technologies Prove Useful to the Future of Drug Discovery
• 2. Market Trends and Regulations
  • 1. Mergers & Acquisition
  • 2. Regulations and Political Factors

3. Technology Adoption Factor Analysis

• 1. Drivers and Industry Trends
  • 1. Technology Drivers
  • 2. Technology Trends
• 2. Challenges and Restraints
  • 1. Challenges
  • 2. Restraints

4. Assessment of Innovations and Opportunities

• 1. Innovative Developments in North America
  • 1. Enzyme Fragment Complementation Assay Technology for Screening Compounds--USA
  • 2. Caliper's LabChip Technology--USA
  • 3. New Molecular Descriptor with High Information Content--USA
  • 4. New Approach in Drug Discovery Technology--USA
  • 5. New Combined Program Offering Quicker Results in Drug Discovery--USA
  • 6. Biosensor Dye Aid Viewing Proteins in Live Cells--USA
  • 7. Integrated Microfluidic Chips to Image the Biology of Disease--USA
  • 8. Small Molecule Based Drug Discoveries for Obesity Autoimmune and Alzheimer's Disease--USA
  • 9. New Technique to Analyse the Toxic Level--USA
  • 10. New Microarray System to Efficiently Examine Gene Regulation --USA
  • 11. Analog for Poly D-Lysine (PDL) for Culture of Fastidious Cells in Normal and Reduced Serum Media--USA
  • 12. Nanopore Device Speeds up the Drug Discovery Process--USA
  • 13. Nanoantenna Help Drug Discovery by Imaging Protein Structure--USA
  • 14. Dual Color Infrared Imaging--USA
• 2. Innovative Developments in Europe/Asia
  • 1. Bio-Analytical Instrument for Effective Drug Discovery--UK
  • 2. System to Speeden the Drug Discovery Process--Moscow
  • 3. High Throughput Electrophysiology for Screening--Sweden
  • 4. Epibase - A New Technology Platform for Drug Discovery--Belgium
  • 5. Novel Solution for Protein Microarrays--Germany
  • 6. MALDI-TOF and TOF/TOF Technology for Proteomics and Biomarker Discovery Studies--Germany
  • 7. 3D Tomography of Flexible Proteins--Sweden
  • 8. Fieldtemplater Technology Helps Ion Channel Drug Discovery--UK
  • 9. Delphi Technology Identifies Receptors--Switzerland

5. Contacts and Patents

• 1. Key Patents
  • 1. Companies
  • 2. Universities
• 2. Key Contacts and Glossary
  • 1. Contacts
  • 2. Glossary

6. Frost & Sullivan 2005 Science and Technology Awards

• 1. Technology Innovation Award
  • 1. Award Description
  • 2. Award Recipient
• 2. Excellence in Technology Award
  • 1. Award Description
  • 2. Award Recipient
• 3. Product Innovation Award
  • 1. Award Description
  • 2. Award Recipient

7. Critical Reference Tables

• 1. Decision Support Database
  • 1. Pharmaceutical R&D Expenditure--World (1999 - 2006)
  • 2. Percent Pharmaceutical R&D Expenditure--World (1999 - 2006)
  • 3. Percent Government Biotech Investment--World (1999 - 2006)
  • 4. Government R&D Investment on Biotechnology--World (1999 - 2006)
  • 5. Private Investment in Biotechnology--World (1999 - 2006)
  • 6. Percent Government Investment in Biotechnology--World (1999 - 2006)