Abstract
Advances in Microscopy Increase Success of Clinical Trials
Rapid technological advances in microscopy foster research on cellular processes and boost pharmaceutical development. These breakthroughs allow cost-effective high-content screening, which monitors live cells, thus reducing instances of clinical trial errors such as adsorption, distribution, metabolism, excretion, and toxicology profiles (ADMET). High-content screening, the latest in the high-end microscopy arsenal, increases chances of drugs satisfying increasingly stringent regulatory safety standards. Cytological profiling is also progressively utilized in trials involving drugs with highly specific biochemical effects, such as kinase inhibitors. Further, progress in imaging technologies and labeling techniques in the life sciences sector enables charting of prominent events within living cells in real-time and in three dimensions (3D).
This Technical Insights study identifies and analyzes not only global emergent, but also novel applications of existing microscopy technologies. The research service also offers in-depth information on R&D and product development. It looks at market trends, drivers and restraints in addition to technical challenges. Case studies, divided into categories by company and university, are included to aid participants plan for the long term effectively.
Microscopy Vital Part of Composition Studies and Non-destructive Testing
As technology in the materials and electronics sector becomes increasingly complex and cutting edge, microscopy is being deployed as an integral part of the multi-billion dollar industry of composition studies and nondestructive testing. Microscopy or visual inspection is, currently, the primary evaluation method of a growing number of quality-control programs to appraise the condition and quality of a weld or component.
"The need for more sophisticated instrumentation will increase as companies develop advanced engineering, industrial, and electronic materials," observes the analyst of this research. "This is especially following recent surveys revealing over 20 percent market share by the world visual inspection equipment segment in the nondestructive test equipment market."
Consumer Demands Shape Dynamics of Microscopy Technology Development
Participants are offering product differentiation -- creating new products and enhancing existing ones -- to combat the growing threat of competition. The resulting boost to microscopy systems and technology also allows overcoming of long-standing challenges such as lens aberration. As conventional microscopy moves into the realm of digitalization, its applications are increasingly automated and integrated. This permits ease of use, encouraging customer preference for simple integrated microscopy systems which reduce end-user confusion.
"Developments in the electron and confocal microscopy along with laser scanning cytometry are impacting this imaging sector positively," elaborates the analyst. "Though not directly related, technology leap of quantum dots and its applications is also a driver for the development of microscopy field."
Table of Contents
- 1. Executive Summary
- 1. Scope and Methodology
- 2. Key Findings
- 1. Noteworthy Emerging Technologies
- 2. Noteworthy Applications
- 3. Assessment of Competing Technologies
- 3. Technology Drivers and Restraints Briefing
- 1. Technology and Market Drivers Outlook
- 2. Technology and Market Restraints Outlook
- 2. Technology and Applications Viewpoint
- 1. Technology Primer
- 1. Light-Based Microscopy - I
- 2. Light-Based Microscopy - II
- 3. Advanced Light-based Microscopy - I
- 4. Advanced Light-based Microscopy - II
- 5. Electron Microscopy - I
- 6. Electron Microscopy - II
- 7. X-ray Microscopy - I
- 8. X-ray Microscopy - II
- 9. Detection And Labelling - I
- 10. Detection And Labelling - II
- 2. Applications Analysis and Trends
- 1. Introduction
- 2. Light and Fluorescence Microscopy Applications
- 3. Technology Roadmap
- 3. Noteworthy Innovation at Key Academic and Government-related Institutions
- 1. Automated Microscopy: Track Broad Effects of Drugs
- 2. Nanoantennas Show Promise in Diagnostic Imaging
- 3. Microscopy Scans Show How Brain Cells Process Energy
- 4. Noteworthy Innovation at Key Companies And Market Factors
- 1. Nanomicroscope
- 2. Worlds Highest-Resolution Electron Microscope
- 3. Influential Market Factors
- 3. Technology Adoption Factor Analysis
- 1. Primary Challenges
- 1. Technology Restraints
- 2. Market Restraints
- 3. Analysis of Competing Technologies
- 2. Analysis of Drivers
- 1. Benefits of Specific Technologies
- 2. Adoption Drivers for Microscopy
- 3. Additional Factors Driving This Sector
- 3. Assessment of Innovation and Opportunities -- North America (Universities)
- 1. Lithographic Technique For Positioning Ssingle Molecules
- 2. Atomic Anchors Discovery A Boost For Nanotech Design
- 3. Reduce Signal-To-Noise Ratio In AFM
- 4. Tomography Method Improves Resolution In Thick Samples
- 5. Nanotech And The Quest For The Perfect Lens
- 6. Perfect Lens Not So Perfect?
- 7. Creating Gold Quantum Dots For Biological Labeling; Optics
- 8. Silica-Dye-Antibody Nanostructure Yields Powerful Fluorescence
- 9. Using Quantum Dots To Tag Faulty Genes
- 10. Launching Cancer Nanotechnology Research Program
- 11. New Center Probes Nanoscale Material
- 4. Assessment of Innovation and Opportunities -- North America (Corporates)
- 1. 3D MRI: Watch one electron spin
- 2. New Technique Improves Power Of Atomic Force Microscopy
- 3. AFM Nanobiochips: A Million Spots In One
- 4. Spinning Up For Spintronics
- 5. Complete Simulations Package For HRTEM
- 6. Prototype Neutron Microscope
- 7. Fluorescence Resonance Energy Transfer (FRET) - Seeking A Better Method
- 8. High-Content Screening: Automated Scans Track Effects Of Drugs On Cells
- 5. Assessment of Innovation and Opportunities -- North America (Company Profiles)
- 1. Quantum Dot Corporation
- 2. Veeco Inc.
- 3. Nikon
- 4. Hitachi And Olympus
- 5. BioForce
- 6. CompuCyte Corp.
- 7. GE Healthcare
- 8. Additional Companies - I
- 9. Additional Companies - II
- 6. Assessment of Innovation and Opportunities -- Europe
- 1. STM Helps to Make Nanoscale LEDs - UK
- 2. AEM for British Nanotech Research - UK
- 3. Fluorescent Probes Form Quantum Dots - UK
- 4. Tiny Lightweight AFM Can Be Used in the Field - Switzerland
- 5. Multiphoton Microscopy 3D Micro-Imaging Technology Licensed - Germany
- 6. Focused Ion Beam Microscopy for Materials - Germany
- 7. New Infrared Nanotechnology - Germany
- 8. Nondestructive Testing STM Measures Vibrations to Find Defects - Germany
- 9. X-Ray Imaging without Lenses - Germany
- 10. Disposable Flow-Through Slides for Cell Culture and Imaging on Same Slide - Germany
- 11. Novel Capsule Enables Scanning Electron Microscopy on Wet Samples - Israel
- 12. Material Microstructures in 4D - Denmark
- 13. Additional Companies
- 7. Assessment of Innovation and Opportunities -- Asia Pacific
- 1. Nanoagglomerates in Epitaxial Thin Films for MRAM Applications - China
- 2. Scanning Probe Microscopy - Korea
- 3. Optical Systems Enable Microscopic Displacement Measurement - Australia
- 4. Make Nano- and Atomic-Scale Devices with Scanning Microscopy - Australia
- 8. Sources of Funding
- 1. Nanotechnology: Governments and Venture Capital
- 2. Government Research Centers
- 4. Patents and Database of Key Industry Participants
- 1. Selected Patents
- 1. Patents I
- 2. Patents II
- 3. Patents III
- 4. Patents IV
- 2. Database of Key Industry Participants
- 1. Key Company Contacts
- 2. Key University Contacts
- 5. Frost & Sullivan 2005 Science and Technology Awards
- 1. Technology Innovation
- 1. Award Description
- 2. Award Recipient
- 2. Technology Leadership
- 1. Award Description
- 2. Award Recipient
- 6. Critical Reference Tables
- 1. Decision Support Database
- 1. Number of Biotech Companies by Region; 1999-2006
- 2. Government R&D Investment in Biotechnology (Million USD) by Region; 1999-2006
- 3. Private Investment in Biotechnology (Million USD) by Region; 1999-2006
- 4. Government Healthcare Expenditure (1999-2006)
- 5. Private Healthcare Expenditure (1999-2006)
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