Rimonabant：首度的大麻酚暢銷藥

Abstract

Marinol®, Cesamet®, Sativex ® and Rimonabant are all commercially-marketed cannabinoids. They treat a variety of conditions from weight-loss to pain relief. The introduction of cannabinoids into the pharmaceutical marketplace has begun, and attitudes to the drugs are changing. This increased acceptance will lead to greater market penetration, and the importance of the area will be seen with the first cannabinoid reaching blockbuster status before the end of the decade.

The growth of this class of products has not yet been realised. As a resource for developing new pharmaceutical products this area will continue to provide potential for the future, and there will be increased R&D efforts into this market. But what treatment areas will benefit? What are the products currently coming through the pipeline? Just how much market potential does this area offer?

Visiongain' s latest report, Rimonabant: The first of the Cannabinoid blockbusters, forecasts the cannabinoid market in 2007 to generate $709 million in sales. This has grown 45% from 2006, when it was generating $386 million. The profile of the market will be raised considerably with Rimonabant, by Sanofi-Aventis, used to treat obesity and set to reach impressive sales in its first few years. Rimonabant, branded Acomplia and Zimulti (US), has now been approved for sale in all 25 countries of the European Union by the European Commission. Make no mistake, major Pharma will not sit around and watch blockbusters being created without wanting to take some of the action. Will you be part of the success? Is this an area that your company is involved in? If not, is it an area you should be involved in? Find out today.

Buying this report will provide you with the answers you need to make those business-critical decisions. Designed as a vital business aid, Rimonabant: The first of the Cannabinoid blockbusters provides the industry' s leading evaluation of the market. Now in its second edition, the report focuses on the following aspects of the worldwide cannabinoid market:

• Current Products
• Pipeline Cannabinoid Products
• Company Profiles and Analysis
• Market Activity
• Revenue Forecasts to 2012
• Regulatory Issues of Cannabinoids in each of the eight major markets
• Alternative therapeutic areas

The report provides in-depth market analysis for current and potential products. The report extensively identifies cannabinoid drugs market potential by analysing the latest clinical trial research and highlighting new indications. The study also assesses the challenges faced by potential companies. Attitudes to cannabinoids are changing - it will experience its first blockbuster.

Why You Must Buy This Report:

This 190+ paged report features over 25 tables, and over 40 graphs and figures. The latest news, insights and analysis of the latest developments are included, with an in depth review of the cannabinoids market. This report is vital to help gain and develop your understanding of this growing sector of the pharmaceutical market, and will give your company ' the edge' over your competitors. You can not afford to be without this latest report from visiongain.

Five key questions this report answers are:

• What is the market potential for cannabinoids treating various diseases?
• What latest clinical trials/experimental research has been performed to develop cannabinoids for therapeutic uses?
• What is the global cannabinoid market value today and what is its future worth?
• When will the cannabinoid market first claim a blockbuster?
• What are the regulatory issues surrounding cannabinoids and medicinal cannabis use in the eight major markets?

Table of Contents

Executive Summary

• E.1 Introduction to the Cannabinoids Market
• E.2 Cannabinoid Potential Therapeutic Areas
• E.3 GW Pharmaceuticals: The Cannabinoid Company

Chapter 1. Introduction

• 1.1 Purpose of Report
• 1.2 Objectives of Report
• 1.3 Scope of Report

Chapter 2. Introduction to Cannabinoids

• 2.1 A Historical Background to Cannabinoid Therapies
• 2.2 An Overview of Cannabinoids
  • 2.2.1 Herbal Cannabinoids
  • 2.2.2 Endogenous Cannabinoids
  • 2.2.3 Synthetic Cannabinoids
• 2.3 How do Cannabinoids Differ to Cannabis?
• 2.4 An Overview of Cannabinoid Receptors
• 2.5 Marinol, Nabilone, Sativex & Rimonabant: The four Medicinal Cannabinoids of Importance
• 2.6 The Therapeutic Potential of Cannabinoids
• 2.7 Major Questions Regarding Cannabinoids
  • 2.7.1 Are They Safe?
  • 2.7.2 What Routes of Administration Will be Used for Therapeutics?

Chapter 3. Potential Cannabinoid Therapies

• 3.1 Cannabinoids of Therapeutic Value
• 3.2 The Cannabinoid Drugs currently on the Global Market
• 3.3 The Potential Clinical Uses of Cannabinoids Overview
• 3.4 Cannabinoids and Pain: An Alternative to Opioids?
  • 3.4.1 Experimentally Induced Acute Pain
  • 3.4.2 Post Surgical Acute Pain
  • 3.4.3 Chronic Pain
  • 3.4.4 Chronic Non-malignant Pain
  • 3.4.5 Neuropathic Pain
    • 3.4.5.1 European Journal of Pain
    • 3.4.5.2 European trials of Sativex
    • 3.4.5.3 Marijuana linked with Peripheral Neuropathy with AIDS sufferers.
  • 3.4.6 Migraine
  • 3.4.7 Cannabinoids and Pain: A Lucrative Market to R&D?
• 3.5 Neurological
  • 3.5.1 Dystonia
  • 3.5.2 Huntington' s Disease
  • 3.5.3 Parkinson' s Disease
    • 3.5.3.1 Cannabinoid Receptors in GP1
    • 3.5.3.2 New Target for Parkinson' s Discovered
  • 3.5.4 Tourette' s Syndrome
  • 3.5.5 Cannabinoids and Movement Disorders: The Future
  • 3.5.6 Cannabinoids and Alzheimer' s Disease: A High Potential
  • 3.5.7 Cannabinoids and Epilepsy: No Trials Performed, Yet
  • 3.5.8 Cannabinoids and Depression: Future Looks Good
  • 3.5.9 Cannabinoids and Traumatic Brain Injury: Prospects Injured
• 3.6 Cancer
  • 3.6.1 Cannabinoids and Cancer-Associated Cachexia/Anorexia: Prospects Look Promising
  • 3.6.2 Cannabinoids and Cancer: A New Hope
    • 3.6.2.1 Skin Cancer
    • 3.6.2.2 Tumour
    • 3.6.2.3 General Cannabinoid Treatments
    • 3.6.2.4 Cannabinoids as antineoplastic agents?
• 3.7 Eating Disorders
  • 3.7.1 Cannabinoids and Obesity: A Large Potential
• 3.8 Dysfunction of the Immune System
  • 3.8.1 Cannabinoids and Multiple Sclerosis: The Most Likely Therapeutic Use
  • 3.8.2 Cannabinoids and Rheumatoid Arthritis: A Possible Use
  • 3.8.3 Cannabinoids and Chron' s Disease/Ulcerative Colitis: Experimental Data Looks Good
• 3.9 Respiratory
  • 3.9.1 Cannabinoids and Asthma: Numerous Studies Performed
  • 3.9.2 Cannabinoids and Intractable Breathlessness: A Rare Answer to an Unknown Disease?
• 3.10 Anti Addiction
  • 3.10.1 Cannabinoids and Drug Withdrawal: A New High?
• 3.11 Miscellaneous
  • 3.11.1 Cannabinoids and Glaucoma: Temporary Relief Found
  • 3.11.2 Cannabinoids and Obstetrics/Gynaecology: Centuries Old Remedies May Hold Potential
  • 3.11.3 Cannabinoids and Diabetes
• 3.12 Visiongain' s Perspective of Cannabinoid Therapeutics

Chapter 4. The Worldwide Cannabinoids Market: Current Cannabinoids and Potential Products

• 4.1 Overview of Today' s Global Cannabinoids Market: A Potential Blockbuster?
• 4.2 Total Global Cannabinoid Market
• 4.3 Marinol
  • 4.3.1 Unimed Pharmaceuticals Inc Markets the Leading Cannabinoid Product Marinol
  • 4.3.2 Marinol was the Standard for Cannabinoid Therapies
  • 4.3.3 Marinol' s Patient Population is Driven by AIDS Wasting
  • 4.3.4 Alzheimer' s Disease Set to Compete With AIDS Wasting Patient Population
  • 4.3.5 Marinol Revenues Boosted by Market Exclusivity and Approval in Various International Markets
  • 4.3.6 Global Marinol Market: First Half of 2004 Revenues Drop Due to Unimed Subsidiaries Distribution Contract Renegotiation
  • 4.3.7 Market Drivers of Marinol
  • 4.3.8 Market Restraints of Marinol
  • 4.3.9 Added Indications of Marinol Will Aid Market Revenues
  • 4.3.10 Unimed and Nektar Therapeutics' Phase I Study of Metered Dose Inhaler (MDI) Holds Promise
  • 4.3.11 Metered Dose Inhaler Formulation of Marinol (Dronabinol)
  • 4.3.12 Cost of Marinol vs. Cannabis
  • 4.3.13 Stages of Development of Marinol
  • 4.3.14 Revenue Forecast 2006 - 2011
• 4.4 Nabilone
  • 4.4.1 Nabilone' s European Market Dominance
  • 4.4.2 Nabilone' s Sales Will Approach the $16.3 million mark in 2007
  • 4.4.3 Cambridge Labs Must Act Now to Maximise Nabilone' s Profits
  • 4.4.4 THC Pharma and Delta 9 Pharma Compete to Supply Germany with Dronabinol (Delta-9- Tetrahydrocannabinol)
  • 4.4.5 Launch of Cesamet oral capsules in USA
  • 4.4.6 Valeant Files Investigational New Drug Application for Cesamet in Cancer Chemotherapy-Induced Neuropathic Pain
  • 4.4.7 Stages of development of Nabilone
  • 4.4.8 Revenue Forecast 2006 - 2012
• 4.5 Sativex
  • 4.5.1 Market Prospects for Cannabinoids Will Decided by Sativex
  • 4.5.2 UK MS Spasticity Status Application of Sativex Rests With MHRA
  • 4.5.3 Dexanabinol' s Traumatic Brain Injury Phase III Results Hinder Cannabinoids Potential?
  • 4.5.4 The Potential Value of the Cannabinoid Market
  • 4.5.5 Stages of development of Sativex
  • 4.5.6 Sativex Revenue Forecast: 2006-2011
• 4.6 Rimonabant
  • 4.6.1 Market Prospects for Cannabinoids Will be Decided by Acomplia
  • 4.6.2 New data shows Acomplia benefited patients with type II diabetes
  • 4.6.3 Acomplia diet pill delayed a third time
  • 4.6.4 Stages of development of Acomplia
  • 4.6.5 Phase III testing of Diabetes
  • 4.6.6 Rimonabant Life-Cycle
  • 4.6.7 Rimonabant Revenue Forecast: 2006-2011
• 4.8 Cannabinoids Potential to Gain Blockbuster Status: Visiongain' s Perspective
• 4.9 Will Cannabinoids Achieve Blockbuster Status? A Survey of Industry Representatives
• 4.10 GW Pharmaceuticals Perspective on Cannabinoids Achieving Blockbuster Status

Chapter 5. Pipeline Cannabinoid Products

• 5.1 Introduction to Cannabinoid Companies
• 5.2 Impressive Cannabinoids Pipeline
• 5.3 Growing Interest of Big Pharmaceuticals in Cannabinoid R&D
• 5.4 Almirall Prodesfarma
  • 5.4.1 Agreement between Almirall and GW
  • 5.4.2 Key Financial Data
• 5.5 Atlantic Technology Venture Inc and Indevus
  • 5.5.1 Indevus acquires and commences Phase II Trials for IP 751 (CT-3)
  • 5.5.2 Indevus' s Pipeline
• 5.6 Bayer Healthcare AG
  • 5.6.1 Bayer has licence to Sativex in the UK
  • 5.6.2 Bayer HealthCare & GW in $41 Million Marketing Agreement
  • 5.6.3 Key Financial Data
• 5.7 GW Pharmaceuticals
  • 5.7.1 GW Pharmaceuticals: The Innovative Leading Cannabinoids Company
  • 5.7.2 GW' s Advance Delivery System (ADS) Received AiM Stock Exchange Award
  • 5.7.3 GW Pharmaceuticals instrumental in developing Sativex
  • 5.7.4 GW Pharmaceuticals to work on Obesity Fighting Drug
  • 5.7.5 Phase III trials of Sativex for neuropathic pain
  • 5.7.6 GW Pharmaceuticals Product Pipeline is Extensive
  • 5.7.7 GW Pharmaceuticals in strategic alliance with Otsuka
• 5.8 MakScientific/Endo Pharmaceuticals Inc
  • 5.8.1 Novel Selective CB2 Agonists from MakScientific/Endo Pharmaceuticals Inc
  • 5.8.2 BTG begin interest in developing CB2 receptor
  • 5.8.3 Total Endo Sales by Region
• 5.9 Novartis
  • 5.9.1 Novartis' Interest in Cannabinoid Agonists for Pain Control
  • 5.9.2 Key Financial Data
• 5.10 Par Pharmaceuticals
  • 5.10.1 Par Pharmaceuticals entered agreement with Valeant
  • 5.10.2 Par Pharmaceuticals announced that Valeant exercised the right to terminate agreement
  • 5.10.3 Key Financial Data
• 5.11 Pharmos Corporation
  • 5.11.1 Pharmos' Cannabinor development
• 5.12 Pfizer
  • 5.12.1 Pfizer' s Four CB1 Candidates
  • 5.12.2 Key Financial Data
• 5.13 Sanofi-Aventis
  • 5.13.1 Sanofi-Aventis' Anti-Obesity /Anti-Smoking Drug Acomplia is a Potential Blockbuster
  • 5.13.2 Rimonabant update in the US
  • 5.13.3 Key Financial Data
• 5.14 Solvay
  • 5.14.1 Bristol-Myers Squibb and Solvay Pharmaceutical' s SLV319 Compound
  • 5.14.2 Key Financial Data
• 5.15 Valeant Pharmaceuticals
  • 5.15.1 Valeant receives two PDUFA dates
  • 5.15.2 Valeant acquires Nabilone
  • 5.15.3 Key Financial Data
• 5.16 Yissum
  • 5.16.1 Yissum Drive Cannabinoid Market Progress with Collaborations and Research Efforts
  • 5.16.2 Yissum from Dexanabinol Agreement Now Under Question

Chapter 6. Regulatory Issues of Cannabinoids and Medically Approved Cannabis

• 6.1 The Politics of Therapeutic Cannabinoid and Cannabis Use
• 6.2 The US
  • 6.2.1 Two FDA Programmes Aid Cannabinoid Drug Development
  • 6.2.2 The DEA Rescheduling of Marinol to Schedule III Increases Availability for Patients
  • 6.2.3 Cannabis Remains under Schedule I of the US 1971 Convention on Psychotropic Substances
  • 6.2.4 Medical Cannabis Legal in Eleven US States
  • 6.2.5 Medical Cannabis Compassion Clubs in the US have Grown in Popularity
  • 6.2.6 New Cannabinoids and Scheduling Regulations in the U.S: Will They Be Subject to Scheduling?
• 6.3 Canada
  • 6.3.1 Regulations Amending the Marihuana Medical Access Regulations (MMAR)
  • 6.3.2 Remaining Acts and Regulations
  • 6.3.2 The first country to approve Sativex
• 6.4 The UK
  • 6.4.1 Schedule I Classification of Misuse of Drugs Act 1971-' No Therapeutic Value'
  • 6.4.2 Dronabinol Rescheduled to Schedule II by UK Government
  • 6.4.3 Cannabinoid Therapeutics: UK Government Willing to Permit Introduction
  • 6.4.4 Home Office License Required to Research Cannabinoids in UK
  • 6.4.5 The House of Lords Science & Technology Committee' s Report on Cannabinoids
  • 6.4.6 Abstract from The House of Lords Science & Technology Committee' s ' Cannabis: The Scientific and Medical Evidence' Report
• 6.5 Japan
  • 6.5.1 Japan' s Cannabis Control Act 1948 Illegalises Medicinal Cannabis and Cannabinoid Research
• 6.6 France
  • 6.6.1 List IV of Decree Law 1990
  • 6.6.2 French Medics Allowed To Prescribe Cannabinoids Under Temporary Use Authorisations
• 6.7 Germany
  • 6.7.1 Schedule II of the Narcotics Act 1996
  • 6.7.2 German Federal Government Breaks Its Promise on Medical Cannabis
  • 6.7.3 German Administrative Court Rejects Law Suits Against the Federal Institute for Pharmaceuticals and Medical Products
• 6.8 Italy
  • 6.8.1 List IV of Decree Law 1992
  • 6.8.2 Four Italian Regions Request Medicinal Cannabis and Its Derivatives
  • 6.8.3 Italian Judge Forces Italy' s NHS to Supply Cannabinoids
  • 6.8.4 Italians Restricted Supplies of Nabilone and Marinol
• 6.9 Spain
  • 6.9.1 No specific Legal Definition of Cannabinoids
  • 6.9.2 Spanish Health Minister Announces Intention of Medical Cannabis Extract Availability

Chapter 7. Conclusion to Cannabinoids

• 7.1 A Potential Blockbuster?

List of figures

• Figure 2.1 Chemical Structures of the Major Cannabinoids
• Figure 4.1 Valeant' s Drug Pipeline
• Figure 5.1 Indevus' s Pipeline

List of graphs

• Graph E.1 Total Cannabinoid Market Revenue Forecast ($bn)
• Graph E.2 Sativex Revenue Forecast ($m)
• Graph E.3 Rimonabant Revenue Forecast ($bn)
• Graph 4.1 Revenues of Cannabinoid Market ($m)
• Graph 4.2 Marinol Revenue Forecast 2006-2012 ($thousands)
• Graph 4.3 Marinol Percentage Growth
• Graph 4.4 Nabilone Revenue Forecast 2006 - 2012 ($)
• Graph 4.5 Nabilone Percentage Growth
• Graph 4.6 Sativex Revenue Forecast 2006 - 2012 ($m)
• Graph 4.7 Sativex Percentage Growth
• Graph 4.8 Rimonabant Revenue Forecast 2006 - 2012 ($bn)
• Graph 4.9 Investment Banks' Revenue Forecast on Rimonabant ($bn)
• Graph 5.1 Alimrall Sales (EUm)
• Graph 5.2 Almirall R&D Costs (EUm)
• Graph 5.3 Almirall Sales By Region (EUm)
• Graph 5.4 Bayer Sales (EUm)
• Graph 5.5 Bayer Net Profit (EUm)
• Graph 5.6 Bayer R&D Costs (EUm)
• Graph 5.7 Bayer Regional Sales ($m)
• Graph 5.8 Novartis Sales ($m)
• Graph 5.9 Novatis Net Profit ($m)
• Graph 5.10 Novartis R&D Costs ($m)
• Graph 5.11 Novartis Sales by Region ($m)
• Graph 5.12 Par Sales ($ thousands)
• Graph 5.13 Par Net Profit ($ thousands)
• Graph 5.14 Par R&D Costs ($m)
• Graph 5.15 Pfizer Sales ($m)
• Graph 5.16 Pfizer Net Profit ($m)
• Graph 5.17 Pfizer R&D Costs ($m)
• Graph 5.18 Pfizer Sales By Region ($m)
• Graph 5.19 Sanofi-Aventis Sales (EUm)
• Graph 5.20 Sanofi-Aventis Net Profit (EUm)
• Graph 5.21 Sanofi-Aventis R&D Costs (EUm)
• Graph 5.22 Sanofi-Aventis Sales By Region (EUm)
• Graph 5.23 Solvay Sales (EUm)
• Graph 5.24 Solvay Net Profit (EUm)
• Graph 5.25 Solvay R&D Costs (EUm)
• Graph 5.26 Solvay Sales By Region (EUm)
• Graph 5.27 Valeant Sales ($m)
• Graph 5.28 Valeant Net Profit ($m)
• Graph 5.29 Valeant R&D Costs ($m)
• Graph 5.30 Valeant Sales By Region ($m)

List of Tables

• Table E.1 Potential Diseases All Cannabinoids May Treat
• Table 2.1 The Major Cannabinoids in Cannabis
• Table 2.2 Properties of the Major Cannabinoids in Cannabis
• Table 2.3 Synthetic Cannabinoids and Their Characteristics
• Table 2.4 Potential Therapeutic Areas of Cannabinoid Therapies
• Table 2.5 Acute and Chronic Adverse Effects of THC
• Table 3.1 Potential Diseases All Cannabinoids May Treat, 2007
• Table 3.2 Cannabinoid Clinical Trial Outcomes of Various Diseases
• Table 3.3 Background to Diseases in Which Cannabinoids may Have a Use
• Table 3.4 The Potential Circumstances for Cannabinoid Use in Pain Control
• Table 3.5 Neuropathic Pain Disorders
• Table 3.6 Target Patients for Cannabinoid Pain Relief
• Table 3.7 Visiongain' s Perspective of the Therapeutic Potential of Cannabinoids by Disease, 2007
• Table 4.1 Revenues of Cannabinoid Market ($m)
• Table 4.2 Top Products in the same Therapeutic Area
• Table 4.3 Stages of Development
• Table 4.4 Countries where Nabilone is Marketed by Cambridge Labs Distribution Partners
• Table 4.5 THC Pharma Cannabinoid Catalogue Products, 2007
• Table 4.6 Stages of Development
• Table 4.7 Stages of Development
• Table 4.8 Stages of Development
• Table 4.9 Investment Banks' Revenue ($bn)
• Table 5.1 Endo Sales by Region
• Table 5.2 Pfizer CB1 Candidates in R&D, 2007
• Table 6.1 Schedule III Benefits of Marinol Compared to Schedule II
• Table 6.2 11 US States That Have Legalised Medical Use of Cannabis

Organisations Listed

• AFT
• Alcasynn Pharmaceuticals
• AOP
• Almirall Prodesfarma
• AstraZeneca
• Atlantic Technology Venture Inc.
• Bayer Healthcare
• Biogen Idec
• BMS
• BTG
• Cambridge Laboratories
• Cedarburg Pharmaceuticals
• Celltech
• Chiesl
• Delta 9 Pharmaceuticals
• Dov Pharmaceuticals
• Eli Lilly
• Endo Pharmaceuticals
• GSK
• GW Pharmaceuticals
• MakScientific
• Medifront
• Medilink
• MegaPharm
• Metaphore Pharmaceuticals
• Nektar Therapeutics
• Novartis
• Orphan Australia
• Otsuka Pharmaceuticals
• Par Pharmaceuticals
• Pfizer
• Pharmos
• Prestwick Pharmaceuticals
• Sanofi-Aventis
• Serb Laboratories
• Serono
• Schering-AG
• Solvay Pharmaceuticals
• Teva Pharmaceuticals
• THC Pharmaceuticals
• Unimed Pharmaceuticals
• Valeant Pharmaceuticals
• Yissum Research Development Co.