Abstract
Proteomics is a rapidly evolving field that is rife with commercial opportunities as the technology achieves ever higher throughput at lower cost and greater sensitivity. Proteomics: Current State and Future Directions is a new CHA Advances report that delivers an up-to-the-minute assessment of the state of proteomics and its applications in drug and biomarker discovery. The report provides insight into:
- Strengths and weaknesses of the leading technologies for protein separation, detection, and quantification - with an emphasis on high-throughput approaches
- The fundamental challenge posed by the vast dynamic range among protein concentrations, and the potential solutions in development and entering the market
- Recent applications of proteomics to discover biomarkers for preeclampsia, and for neonatal ureteropelvic junction, and to differentiate between diagnosis of ALS and Parkinson' s disease
- Technologies such as mass spectrometry, antibody-bearing chips, and solution array multiplexing to address the challenge of detecting low-abundance proteins
- The most significant research initiatives and recent product introductions, company profiles, and the major deals and M&As that are shaping the proteomics landscape
Table of Contents
SECTION 1
- Introduction: The Current State of Proteomics Technology
SECTION 2
- A Brief History of Proteomics Technology
SECTION 3
- General Overview of Proteomics Research Challenges
SECTION 4
- Current Technologies
- Protein Separation/Sample Enrichment
- Liquid Chromatography
- Protein Removal
- Mass-coded Labeling
SECTION 5
- Research Comparing Quantification Methods
- Protein Identification and Quantification
- Mass Spectrometry
- Common MS Instrument Types
- Antibody/Protein Array Applications
- Protein Indentification and Quantification, Antibodies
- Protein-Protein Interaction
SECTION 6
- Technical Challenges
- Dynamic Range
- Albumin Removal
SECTION 7
- Selected Research Methods Reports
- Protein microarrays
- Sample Complexity
- Multiphoton Detection
SECTION 8
- Selected Product Introductions
- Beckman-Coulter
- Sigma-Aldrich
- Cambrex
- Serva Electrophoresis
- PerkinElmer
- Thermo Electron
- Sigma-Aldrich
- Agilent Technologies
- Bruker Daltonics
- KREATECH
- Axela Biosensors
- Syngene
- Sigma-Aldrich
SECTION 9
- Selected Deals and Mergers
- Combi Matrix/Biodesign Institute
- Caprion/ICOS
- Affibody/Agilent
- PerkinElmer/Agilix
- Applied Biosystems/Invitrogen
- PerkinElmer/Luminex
SECTION 10
- Expert Interviews: Current State and Future Directions
- Roger Brent, PhD
- Gilbert S. Omenn, MD, PhD
- James R. Heath, PhD
SECTION 11
- Selected Company Profiles
- BiaCore
- BioRad
- Invitrogen
- Luminex
- Thermo Electron
APPENDIX
- CHA Advances - 2006 Proteomics Survey
