Abstract
Executive Summary
Despite the heavy investment made into brain cancer research, primary brain cancer, with glioblastoma multiforme being the most aggressive and most common form, remains one of the most deadly diseases in the developed world. While primary brain tumors are relatively rare, the chances of survival for patients with the disease are very low, even with the best treatment options currently available. Datamonitor predicts that there will be around 26,000 new cases of glioblastoma multiforme diagnosed in the seven major markets (US, Japan, France, Germany, Italy, Spain and UK) in 2007. In the US alone, around 14,000 people will die from brain cancer in 2007.
There are today more than 125 therapeutics targeting brain cancer, from early preclinical to marketed drugs. Brain Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 75 different targets. These targets are further categorized on the CD-ROM by 30 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Brain Cancer Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
- Investigators
- Includes more than 115 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
- Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
- Drug name & Synonyms
- Lists commercial, generic and code names for drugs. In all more than 200 names
- Developmental stage
- This Drug Pipeline Update contains more than 125 drugs in active development for the treatment of brain cancer:
- 9 marketed drugs
- > 10 projects in Phase III
- > 50 projects in Phase II
- > 20 projects in Phase I
- > 30 projects in Preclinical
- Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
- Indications
- Included brain cancer drugs are also in development for over 100 other indications.
- Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
- Targets
- Identified drugs are linked to more than 75 different targets,
divided into 30 classifications of molecular function:
- - Auxiliary transport protein activity
- - Catalytic activity
- - Cell adhesion molecule activity
- - Cysteine-type peptidase activity
- - Cytokine activity
- - DNA repair protein
- - DNA topoisomerase activity
- - DNA-directed DNA polymerase activity
- - Extracellular ligand-gated ion channel activity
- - G-protein coupled receptor activity
- - Growth factor activity
- - Ion channel activity
- - Kinase activity
- - Ligand-dependent nuclear receptor activity
- - Lipid kinase activity
- - Lipid phosphatase activity
- - Molecular function unknown
- - Peptidase activity
- - Protein serine/threonine kinase activity
- - Receptor activity
- - Receptor signaling protein serine/threonine kinase activity
- - Receptor signaling protein tyrosine phosphatase activity
- - Structural constituent of cytoskeleton
- - T cell receptor activity
- - Transcription factor activity
- - Transcription regulator activity
- - Transferase activity
- - Translation regulator activity
- - Transmembrane receptor activity
- - Transmembrane receptor protein tyrosine kinase activity
- Identified targets are categorized into 11 different primary and
alternate sub-cellular localizations:
- - Cell surface
- - Clathrin-coated vesicle
- - Cytoplasm
- - Cytosol
- - Endoplasmic reticulum
- - Endosome
- - Extracellular
- - Mitochondrion
- - Nucleolus
- - Nucleus
- - Plasma membrane
- Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
- Identified drugs are linked to more than 75 different targets,
divided into 30 classifications of molecular function:
- Target Expression Profile
- Direct links are provided from inside the application to 52 protein
expression profiles of 42 drug targets in various human tissues and cancer
types, cell lines and primary cells, includin u to
- - 48 different normal tissue types
- - 20 different types of cancer
- - 47 cell lines
- - 12 samples of primary blood cells
- Direct links are provided from inside the application to 52 protein
expression profiles of 42 drug targets in various human tissues and cancer
types, cell lines and primary cells, includin u to
- Pathway Referals
- Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
- - BioCarta 180 Pathways
- - KEGG 51 Pathways
- - NetPath 17 Signaling Pathways
- Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
- Mechanism
- In total there are more than 90 different drug mechanism of action represented in this Drug Pipeline Update.
- Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
- Compound
- Identified drug compounds are described by:
- Compound type, Chemical name, CAS Number and molecular weight
- Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
- Drug Profile
- Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
- Drug Name & Synonyms
- Presentation of drug name and synonyms
- Principal Investigator & Partners
- Presentation of principal investigator and partners
- Target and Molecular Function of Target
- Described target(s) is/are presented with:
- Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
- Target Localization
- Described target(s) is/are presented with primary and alternate localizations.
- Target Expression Profiles
- Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
- Targeted Pathways
- Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
- Mechanism
- Drug mechanism of action
- Developmental Projects
- Summary field of developmental projects for the drug, including indication, developmental stage and status.
- Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
- Drug Description
- Short introduction to drug
- Compound Data
- Compound type, Chemical name, CAS Number and molecular weight
- Patent Data
- Available patent information related to the drug is presented here.
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
- Phase III Data
- Available Phase III development data, developmental history and scientific data.
- Phase II Data
- Available Phase II development data, developmental history and scientific data.
- Phase I Data
- Available Phase I development data, developmental history and scientific data.
- Preclinical Data
- Available preclinical development data, developmental history and scientific data.
- Licensing Information
- Availability for licensing
- Application Features
- Use 13 different parameters, available in drop-down menus, to find
and sort among drugs
- - Drug status
- - Clinical Trial Status
- - Principle Investigator
- - Partners
- - Indication
- - Developmental Stage
- - Compound Type
- - Mechanism
- - Target
- - Molecular Function of Target
- - Target Localization
- - Targeted Pathways
- - Free text search of entire drug profile contents
- Direct linkage from inside the application to related internet
resources
- - Drug data is linked to search engines like Google and PubMed
- - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
- - Direct links to company web pages of principal investigators
- Export and sharing of information
- - Found information is easily shared with others over e-mail, file export (xls) or in print
- Use 13 different parameters, available in drop-down menus, to find
and sort among drugs
- System Requirements
- - AMD-Athlon/Pentium II PC
- - Windows 98/NT4/2000/ME/XP/VISTA
- - 8x-speed CD Rom drive
- - SVGA 16 bit display. (32 bit recommended)
- - 32 MB of available RAM (128 MB recommended)
- - Internet access (for related internet resources)
