質量分析：生命科學市場中的機會

Abstract

Mass spectrometry (MS) is an analytical technique that is used to identify unknown compounds, quantify known compounds, and elucidate the structure and chemical properties of molecules. Traditionally large, intricate and expensive instruments, mass spectrometers are most often found in core facilities, however, lower cost models have recently been launched--enabling smaller groups of life scientists to acquire them. Designed to provide a detailed analysis of this expanding market from the end-users perspective, Mass Spectrometry: Opportunities in the Life Science Market examines researchers experimental design, instrument configurations and future purchasing plans. Based on 36-question survey of 850 scientists who currently use, or plan to use, mass spectrometry in their research, it thoroughly analyzes scientists loyalty to the supplier of their most recently purchased mass spectrometer as well as purchasing motivations, likelihood to recommend that supplier and likelihood to re-purchase. In addition to assessing users satisfaction with specific features of the instrument, it explores the current use of quantitative proteomics methods and highlights developments needed to encourage widespread use.

The major objectives of this report are as follows:

• Benchmark the current usage and applications of mass spectrometers and project future usage and applications
• Identify the mix of mass spectrometer suppliers currently used and future purchasing plans
• Establish the supplier of the labs newest mass spectrometer, when it was purchased and the reason for its purchase
• Determine the mass spectrometer specifications including ion sources, ionization detectors, instrument configuration and analysis software
• Evaluate the level of customer loyalty towards, and satisfaction with, mass spectrometer suppliers
• Establish the current use of quantitative proteomics methods and project scientists future needs

Table of Contents

Section 1. Analysis and Interpretation of Survey Results

Introduction

Application-Driven Mass Spectrometer Parameters

1-3 Ionization Techniques

1-4 Instrument Configurations

1-6 Sample Preparation and Complexity

1-7 Throughput Levels

1-8 Sample Origin

Mass Spec Market Dynamics

1-9 Leading Suppliers

Customer Satisfaction and Loyalty

1-11 Product Performance Attributes

1-12 Overall Satisfaction by Brand

1-13 Likelihood to Repurchase and/or Recommend

1-15 Customer Loyalty Scores by Brand

Market Dynamics

1-16 Influencers of Future Purchasing

1-17 Purchase Motivation

1-18 Expectations for Growth

Emerging Applications: Focus on Quantitative Proteomics

1-19 Quantitative Proteomics Use and Methods

1-20 Product Performance Attributes

1-21 Desired Improvements

Conclusion

Section 2. Study Methodology and Demographics

2-1 Methodology

2-6 Definition of Terms

2-7 Demographics

2-8 Questionnaire

Section 3. Presentation of Survey Data

Usage and Applications (Respondents = 653)

3-1 Use of mass spectrometry in research

3-5 Types of scientists*

3-6 Applications for which mass spectrometry is performed

3-7 Applications for which there are plans to perform mass spectrometry*

3-8 Origins of the primary sample studied using mass spectrometry*

3-11 Most significant advantages of identifying proteins using mass spectrometry

3-12 Ways in which protein samples are prepared for mass spectrometer analysis

3-13 Complexity of the samples analyzed by mass spectrometry

3-14 Locations of the mass spectrometers used most often

3-15 Future plans to purchase mass spectrometers

3-16 Timeframe for purchasing new mass spectrometers**

3-17 Suppliers from which new mass spectrometers are most likely to be purchased**

Throughput (Respondents = 380)

3-19 Average number of mass spectrometer analyses performed per month

3-20 Change in number of analyses performed over the next 12 months

Mass Spectrometer Instruments (Respondents = 380)

3-22 Number of accessible mass spectrometers

3-23 Suppliers of accessible mass spectrometers and suppliers of the newest mass spectrometers

3-25 Ionization sources used in mass spectrometry

3-26 Ion detectors used in mass spectrometry

3-27 Instrument configurations used in mass spectrometry

Most Recently Purchased Mass Spectrometers (Respondents = 380)

3-28 When the newest mass spectrometers were purchased

3-29 Reasons why mass spectrometers were purchased from particular suppliers

3-30 Types of software used to analyze the data obtained from the most recently purchased mass spectrometers

3-31 Types of information provided by the software used to analyze the spectral data from the most recently purchased mass spectrometers

3-32 Satisfaction with specific features of the most recently purchased mass spectrometers

3-34 Overall satisfaction with the most recently purchased mass spectrometers

3-35 Change in opinion of most recent supplier

3-36 Likelihood to purchase a mass spectrometer again from the same suppliers

3-37 Likelihood to purchase other equipment from the most recent suppliers

3-38 Likelihood to recommend a mass spectrometer from the most recent suppliers

3-39 Most important features of a new mass spectrometer

Quantitative Proteomics (Respondents = 99)

3-40 Familiarity with methods to quantify protein expression

3-43 Planned use of methods to quantify protein expression

3-44 Satisfaction with specific characteristics of the method used for protein quantification

3-46 Overall satisfaction with the method used for protein quantification

3-47 Performance of multiplexing

3-48 Most important areas of development to increase the widespread use of quantitative proteomics

3-4 Greatest challenges with regards to the adoption of mass spectrometry

Section 4. Appendices

4-1 Insights and Perspectives

4-27 Cross-Tabulations of Survey Data

4-112 Quadrant Analysis for Mass Spectrometer Attributes

4-119 Other Recent Publications

4-121 About BioInformatics

4-122 Our Valued Clients

*Based on the responses of 653 scientists who currently use MS in their research and 197 scientists who plan to use MS.

**Based on the responses of 125 scientists who have plans to purchase a mass spectrometer.