INTRODUCTION
STUDY GOALS AND OBJECTIVES
This report focuses on DNA microarrays that now play a key rolein product
development in thepharmaceutical industry. Microarrays are also widely used in
academic research throughout biology and biochemistry. Consequently, the markets
for microarrays are effectively split between academia and industry.
DNA microarrays have their roots in the chemical methods of gene analysis that
developed over the past four decades. But the transition from solution chemistry
to a microarray has been confronted with a number of challenges. Coupled with
the practical completion of the human genome project, there has been intense
interest in characterizing the biological mechanisms that underlie human and
animal physiology. While solution chemistry relied on characterizing one to
perhaps a dozen genes at a time, microarrays focus on thousands of genes at
once.
Needless to say, this has lead to an explosion of microarray data, and this
field gives new meaning to the phrase "drowning in data." Simply put,
although there is a great deal of data being generated, tools to analyze it are
not keeping pace. Consequently, it has become very difficult to fully analyze
microarray data. This is now one of the major issues in the field. However, it
has not stopped most laboratories from both purchasing and using microarrays.
While there are a number of studies that have looked at the overall markets for
microarrays, there has been a dearth of information concerning the materials
used to make these goods. In some cases, material requirements for microarrays
have been satisfied by using products of existing industries. These components
such as substrates and probe molecules have then been incorporated into DNA
microarrays.
Often, these products require modifications to make them suitable for use on a
microarray, but the modifications are generally performed by the existing
industry. For other materials used in microarray production, such as marker
molecules, microarray requirements have forced development of new technology.
(Marker molecules are used to indicate whether or not a biological target has
bound to the probe molecule attached to the substrate. This process is called
hybridization, and is the basis for microarray function.) Even in the field of
existing technology such as the production of DNA oligomers, new producers have
sprung up to fuel the DNA microarray market.
This report will help answer the following questions:
- What are the changes taking place in the microarray industry?
- Which companies produce microarrays, and which firms produce products used to manufacture microarrays? The substrates? The probe molecules? The marker molecules?
- What are the important trends to watch for with regard to microarrays?
REASONS FOR DOING THIS STUDY
While a number of market forecasts relating to microarrays exist, few have
covered in any detail the materials used to produce them. Not only has
microarray production become a significant industry with sales in the several
hundreds of millions of dollars, but the goods needed to supply microarray
production have become its own industry as well.
Many estimates of microarray market size have presented a very incomplete
picture, especially since they have been based more on wishful thinking than
careful analysis. Some sources predicted the early demise of DNA microarrays,
saying they would be replaced by protein microarrays or microfluidics devices.
This report does not agree with these assessments; it covers the technology of
both DNA and other types of microarrays with enough detail for readers to draw
their own conclusions.
This report examines the current microarray market and the materials used to
produce these goods. Readers of this report will be able to distinguish the hype
associated with microarrays from the reality of the market. Readers also will be
able to make plans based on current and future trends in this business, since
some DNA microarrays and materials are waning in popularity and will be replaced
by different technologies.
CONTRIBUTION OF THE STUDY
There have been some wild claims made for the DNA microarray market. Some
forecasts have valued the market for these goods at more than $1 billion, with
continued double-digit growth. This report takes a much more hardheaded look at
the overall microarray market, and the materials used to produce them.
Overall, DNA microarray use will continue to increase over the next few years,
but the product mix is showing some dramatic changes. These changes may affect
suppliers of materials to the microarray market more than the microarray
manufacturers, since the manufacturers' first concern is whether or not their
microarrays will be marketable.
With this information, readers with business interests can make sound judgments
regarding marketing strategies, investment decisions, or strategic plans
concerning the marketing of microarrays. This report has been written to be
readily accessible for readers with a business background. But accuracy of the
technological aspects of microarrays has not been sacrificed.
SCOPE AND FORMAT
This report focuses on DNA microarrays and the materials used to produce them
including substrates, probe molecules and marker molecules. Microarrays are
widely used in the pharmaceutical industry and in academia. This report briefly
covers their uses in these broad applications, and details the costs of actually
using them.
The report does not include market evaluations of antiterrorist applications,
clinical applications, or other environmental detection applications that may
use microfluidics devices, protein microarrays or DNA microarrays. Protein
microarrays and microfluidics devices are not considered to be commercially
important at this time. Thus, the report covers the industry devoted to
producing these goods and some of the technology behind them. It does not cover
in much detail the materials used to produce either microfluidics devices or
protein microarrays. Therefore, most of the report focuses heavily on DNA
microarrays.
The report is broken into four sections:
- an industry structure section that details the makeup of the firms that produce microarrays and those that produce materials used in microarray production, along with selected company profiles
- an extensive technology overview that covers the relevant technology of DNA microarray production and materials, along with comparisons of various technologies
- a thorough description of the available products for DNA microarrays, and the materials used to produce them
- a concluding market applications section that discusses some of the relevant trends in the use and costs of DNA microarrays.
METHODOLOGY AND INFORMATION SOURCES
This report is the end result of five months of concerted effort by the
author. Primary information sources were interviews with several dozen people in
industry, academia and the government. Many of the people interviewed are
recognized authorities in the field, and provided invaluable assistance and
insight, and I would like to thank all who took the time to speak with me for
their help with this project.
This study was not commissioned by any corporation or individual, and is thus as
objective as is possible.
Secondary sources include a number of publications issued by the federal
government, as well as items from the Internet, corporate literature and
peer-reviewed publications.
Any time an estimate has been made, the underlying assumptions are discussed.
Thus, if readers choose to interpret the raw data in a differing manner, it is
possible to do so. Dollar amounts are in constant 2002 dollars, and average
annual growth rates (AAGRs) are calculated using standard tables.
TABLE OF CONTENTS
INTRODUCTION
- STUDY GOALS AND OBJECTIVES
- REASONS FOR DOING THIS STUDY
- CONTRIBUTION OF THE STUDY
- SCOPE AND FORMAT
- METHODOLOGY AND INFORMATION SOURCES
- AUTHOR'S CREDENTIALS
- RELATED PUBLICATIONS
- BCC ONLINE SERVICES
- DISCLAIMER
SUMMARY
- Summary Table:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, THROUGH 2007 ($ MILLIONS) - Summary Figure:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, 2002 AND 2007 ($ MILLIONS)
INDUSTRY STRUCTURE
- INTRODUCTION
- INTRODUCTION (CONTINUED)
- MICROARRAYS AND MICROFLUIDICS DEVICES
- PRODUCERS OF DNA BIOCHIPS AND MICROARRAYS: PHOTOLITHOGRAPHIC CHIPS AND GLASS ARRAYS
- Photolithographic Microarrays
- Affymetrix Substrates
- Affymetrix Biomolecules
- Sequence Information of Affymetrix Biomolecules
- Affymetrix Marker Molecules
- Overall Production Costs
- Photolithographic Microarray Developers
- Photolithographic Microarray Processors
- Table 1 FIRMS OFFERING AFFYMETRIX SLIDE PROCESSING
- THE GLASS ARRAY INDUSTRY
- A Brief History of Glass Microarrays
- Spotted and Unspotted Glass Arrays
- Spotted and Unspotted Glass Arrays (Continued)
- Spotted Arrays
- Table 2 SPOTTED DNA MICROARRAY MANUFACTURERS, 2002
- Unspotted Arrays
- Unspotted Arrays (Continued)
- Table 3 VENDORS OF SUPPLIES AND EQUIPMENT TO THE UNSPOTTED MICROARRAY
MARKET
- Microarray Production by Volume: High-volume Producers
- Table 4 HIGH-VOLUME DNA MICROARRAY PRODUCERS (GLASS AND
PHOTOLITHOGRAPHIC), 2002
- The Low-volume Microarray Industry
- Table 5 MICROARRAY PRODUCTION ON A VOLUME BASIS, 2002 AND 2007 (%)
- Licensing in the Microarray Industry
- A Brief History of Licensing in the Microarray Industry
- Licensing Involving Fluorophores
- Effects of Licensing on the U.S. Industry
- Table 6 EFFECTS OF LICENSING ON THE DNA MICROARRAY INDUSTRY
- Barrier to Foreign Competition
- Barriers to Entry of New Technology
- Decreased Competition
- Intellectual Property Involving Biomolecules
- Table 7 METHODS FOR HANDLING INTELLECTUAL PROPERTY (IP) IN MICROARRAY AND
BIOCHIP PRODUCTION
- Sequence Information Producers
- Costs
- Litigation Possibilities
- Overall Use
- THE PROTEIN CHIP INDUSTRY
- Table 8 PROTEIN MICROARRAY PRODUCERS
- Table 9 PROTEIN PRODUCERS OF BIOCHIPS, BY TYPE
- THE MICROFLUIDICS CHIP INDUSTRY
- Table 10 FIRMS IN THE MICROFLUIDICS INDUSTRY
- MATERIALS FOR MICROARRAYS AND MICROFLUIDICS DEVICES
- MATERIALS FOR MICROARRAYS .. (CONTINUED)
- BIOCHIP AND MICROARRAY SUBSTRATES
- Glass Substrates
- MATERIALS FOR MICROARRAYS AND MICROFLUIDICS DEVICES
- Table 11 GLASS AND POLYMER USE IN SUBSTRATES, 2002 AND 2007 (%)
- Unspotted Substrate Producers
- Table 12 SUPPLIERS OF UNSPOTTED GLASS SUBSTRATES FOR BIOCHIPS, 2002
- The Spotted Glass Substrate Industry
- History of the Agreement Between Amersham and Surmodics
- Polymer Substrates
- Table 13 SUPPLIERS OF POLYMER SUBSTRATES FOR BIOCHIPS, 2002
- Silicon Substrates
- BIOMOLECULES
- DNA Producers
- DNA Oligomers
- Table 14 CAPTIVE AND OPEN PRODUCTION OF DNA OLIGOMERS FOR MICROARRAYS,
2002 AND 2007
- Open Production of DNA Oligomers in Glass Arrays
- A Brief History of DNA Oligomer Production
- Table 15 OLIGOMERIC DNA PRODUCERS, 2002
- Oligo Pricing
- Purified Oligomers
- Oligomer Modifications
- Production of cDNA in the Glass Array Industry
- Table 16 COMMERCIAL PRODUCERS OF CLONED DNA FOR MICROARRAYS
- Table 17 CAPTIVE VS. OPEN cDNA PRODUCTION
- MARKER MOLECULES
- Table 18 DNA LABEL SUPPLIERS, 2002
- Fluorophore Labeling Types
- Direct Label Producers
- Table 19 DIRECT DNA LABEL PRODUCERS
- Indirect Label Producers
- Table 20 INDIRECT DNA LABEL PRODUCERS
- AFFYMETRIX, INC.
- GENISPHERE, INC.
- XENOPORE CORP.
- SURMODICS
- IDT
- ENZO LIFE SCIENCES, INC.
- ICONIX PHARMACEUTICALS, INC.
- INCYTE CORP.
- AGILENT TECHNOLOGIES
- AMERSHAM BIOSCIENCES
- PERKINELMER
- QIAGEN GMBH
- SIGMA-GENOSYS
- BD BIOSCIENCES CLONTECH
- CORNING, INC.
- GENICON SCIENCES CORP.
TECHNOLOGY OVERVIEW
- WHAT IS A BIOCHIP?
- STATIC BIOCHIPS
- WHAT A STATIC BIOCHIP IS
- Table 21 STATIC BIOCHIP COMPONENTS
- Substrates
- Probe Molecules
- Marker Molecules
- WHAT A DNA MICROARRAY DOES
- What a DNA Microarray Does (Continued)
- Quantification Using Microarrays
- The Larger Gene Expression Picture
- The Larger Gene Expression Picture (Continued)
- The Larger Gene Expression Picture (Continued)
- The Larger Gene Expression Picture (Continued)
- Microarray Design
- Table 22 KEY CHALLENGES IN DESIGNING MICROARRAY PROBES
- Base Pair Mismatches
- Poor Binding
- Hybridization
- Variable Signal Strengths
- Interpretation of Microarrays
- Intramicroarray Variability
- Intermicroarray Variability
- Variations in Analysis
- Challenges to Microarray Materials
- Table 23 CHALLENGES TO MATERIALS USED IN MICROARRAYS
- Substrates
- Probes
- Marker Molecules
- DNA Microarray Performance Requirements
- Table 24 DNA MICROARRAY REQUIREMENTS
- Firm Tethering
- Unhindered Binding
- Using Larger DNA Molecules
- No Cross-contamination
- Unreactive Surface
- Current DNA Microarrays
- PHOTOLITHOGRAPHY TECHNOLOGY
- Photolithography Technology (Continued)
- The Incomplete Reaction Problem
- Probe Design
- Development Trends
- GLASS ARRAYS
- Amersham's Coating Technology
- Agilent Technology
- Probe Technology
- COMPARISON OF INKJET AND PHOTOLITHOGRAPHIC TECHNOLOGY
- Table 25 COMPARISON OF PHOTOLITHOGRAPHIC AND INKJET BIOCHIP PRODUCTION
TECHNOLOGIES
- Production Rates
- Requires Masks
- Adaptability
- Cross-contamination
- Feature Size
- Probe Accessibility
- Probe Purity
- Overall Performance
- Market Acceptance
- PROTEIN MICROARRAYS
- Table 26 CHALLENGES IN DETECTING PROTEINS
- Difficult to Detect
- Complex in Formation
- Lack of Binding
- Posttranslational Modification
- Costs
- Competing Technologies
- Summary
- MATERIALS TECHNOLOGY
- SUBSTRATES
- A Brief History of Substrate Development
- Table 27 COMPARISON OF POROUS AND NONPOROUS SUBSTRATES
- Materials
- Coatings
- Control of Spot Size
- Diffusion Mechanisms
- Glass and Polymer Substrates
- Table 28 COMPARISON OF POLYMER AND GLASS SUBSTRATES FOR BIOCHIPS AND
ARRAYS
- High-throughput Applicability
- Can Be Used with Photolithography or Inkjet?
- Surface Smoothness and Machinability
- Easily Coated
- Types of Coatings
- The Importance of Coatings
- Relevance of Coatings in the Courtroom
- Glass Coating Technology for Substrates
- UV Coatings
- Covalent Coatings
- Table 29 COMPARISON OF UV AND COVALENT COATINGS FOR SUBSTRATES
- Utility with Production Technologies
- Free Radicals
- Monolayers
- Spacer Requirements
- Patents
- Markets
- PROBE TECHNOLOGY
- Table 30 PROBE REQUIREMENTS
- Selectivity
- Tight Binding
- Ease of Manufacture
- cDNA Technology
- Table 31 PROBLEMS WITH PCR
- Time Consuming
- Breakdown
- Accuracy
- Expensive
- Sensitivity
- Selectivity
- MARKER TECHNOLOGY
- Table 32 COMPARISON OF DETECTOR TECHNOLOGY
- Accuracy
- Sensitivity
- Ease of Use
- Challenges in Labeling DNA Microarrays
- Table 33 CHALLENGES IN THE MICROARRAY LABELING PROCESS
- Specific Binding
- Must Fluoresce or Signal in Proportion to Binding
- Must Not Hinder Hybridization
- Must Be Stable
- Must Emit a Clean Signal
- MICROFLUIDICS TECHNOLOGY
- Table 34 COMPARISON OF STATIC AND DYNAMIC BIOCHIPS AND ARRAYS
- USE
- FLOW
- SUBSTRATES
- APPLICATIONS
- EASE OF USE
- Ease of Use (Continued)
PRODUCTS
- INTRODUCTION
- THE OVERALL BIOCHIP MARKET
- Table 35 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 1 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS
DEVICES, 2002 AND 2007 ($ MILLIONS)
- THE OVERALL BIOCHIP MARKET (CONTINUED)
- DNA MICROARRAYS
- Table 36 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 2 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, 2002, 2003 AND
2007 ($ MILLIONS)
- DNA GLASS ARRAYS
- Table 37 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 3 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, 2002, 2003 AND 2007 ($
MILLIONS)
- Industry Trends
- Industry Trends (Continued)
- Table 38 COMPARISON OF PRESPOTTED AND UNSPOTTED MICROARRAYS
- Ease of Use
- Production Methodology
- Costs
- Unspotted Arrays by Market
- Table 39 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 4 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, 2002, 2003
AND 2007 ($ MILLIONS)
- Microarrays by Type
- Table 40 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 5 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, 2002, 2003 AND 2007 ($
MILLIONS)
- CDNA and Oligo Microarrays by Market
- Table 41 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 6 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, 2002, 2003 AND 2007 ($ MILLIONS)
- Table 42 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 7 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, 2002,
2003 AND 2007 ($ MILLIONS)
- MATERIALS USED IN MICROARRAYS
- Table 43 MATERIALS USED IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
- Figure 8 MATERIALS USED IN DNA MICROARRAYS, 2002 AND 2007 ($ MILLIONS)
- SUBSTRATES
- Coated and Uncoated Substrates
- Table 44 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 9 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND
2007 ($ MILLIONS)
- Glass Substrates by Coating Type
- Table 45 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Figure 10 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
- Table 46 GLASS SUBSTRATES BY COATING TYPE, 2002 AND 2007 (%)
- BIOMOLECULES
- DNA Probes by Type
- CDNA
- CDNA by Markets: Pharmaceutical
- Academic Markets
- Table 47 MARKETS FOR cDNA IN GLASS MICROARRAYS, THROUGH 2007 ($ MILLIONS)
- Figure 11 MARKETS FOR cDNA IN GLASS MICROARRAYS, 2002, 2003 AND 2007 ($
MILLIONS)
- Oligomeric DNA
- Oligomeric DNA by Production Methodology
- Table 48 COMPARISON OF IN SITU AND INDEPENDENTLY SYNTHESIZED DNA OLIGOMERS
- Production Technology
- Oligomer Length
- Accuracy and Quality Control
- Cross-contamination
- Production Costs
- Table 49 MARKETS FOR DNA OLIGOMERS AND AMIDITES IN DNA MICROARRAYS,
THROUGH 2007 ($ MILLIONS)
- Protein Probes
- MARKER MOLECULES
- Table 50 COMPARISON OF DIRECT AND INDIRECT LABELING
- Table 51 DIRECT AND INDIRECT LABELING, 2002, 2003 AND 2007 (%)
- Marker Molecules by Technology
- Table 52 COMPARISON OF VARIOUS MARKER MOLECULE TECHNOLOGIES
- Stability
- Instrumentation
- Costs
- Table 53 MARKER MOLECULE MARKETS, THROUGH 2007 ($ MILLIONS)
MARKET APPLICATIONS
- INTRODUCTION
- DNA MICROARRAY MARKETS
- Table 54 INDUSTRIAL AND ACADEMIC MICROARRAY MARKETS, THROUGH 2007 (UNITS
AND $ THOUSANDS)
- MICROARRAY APPLICATIONS
- Table 55 COMPARISON OF THREE PROPOSED MICROARRAY APPLICATIONS: EXPRESSION
PROFILING, DIAGNOSIS AND SNP DETECTION
- Current Use
- Technology Developments
- Diagnostics
- Theoretical Underpinnings of Microarray Applications
- Expression Profiling
- SNPs
- Diagnostics
- THE ACADEMIC RESEARCH MARKET
- MICROARRAY PRODUCTION IN ACADEMIA
- Table 56 REASONS FOR CORE FACILITIES
- Microarray Production in Academia (Continued)
- Microarray Production in Academia (Continued)
- Numbers of Core Facilities
- Table 57 ACADEMIC MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS),
THROUGH 2007 (UNITS AND $ THOUSANDS)
- Pricing of Arrays in Academia
- Array Costs
- Table 58 BREAKDOWN OF COSTS FOR RUNNING A GLASS ARRAY IN ACADEMIA
- Substrate/Oligomer Costs
- Processing Costs
- Amplification
- Hybridization
- DNA Synthesis Kit
- Marker Molecules
- Photolithographic
- Glass Arrays
- MICROARRAY FUNDING
- The Catch-22 of NIH Funding
- INDUSTRIAL MARKET APPLICATIONS
- TYPES OF MICROARRAYS USED BY INDUSTRY: GLASS AND PHOTOLITHOGRAPHIC ARRAYS
- Table 59 INDUSTRIAL MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS),
THROUGH 2007 (UNITS AND DOLLARS IN THOUSANDS)
- Pricing of Microarrays Used in Industry
- Photolithographic Arrays
- Glass Arrays
- Processing Costs
- Trends in Microarray Use
- Trends in Microarray Use (Continued)
LIST OF TABLES
- Summary Table:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, THROUGH 2007 ($ MILLIONS) - Table 1 FIRMS OFFERING AFFYMETRIX SLIDE PROCESSING
- Table 2 SPOTTED DNA MICROARRAY MANUFACTURERS, 2002
- Table 3 VENDORS OF SUPPLIES AND EQUIPMENT TO THE UNSPOTTED MICROARRAY MARKET
- Table 4 HIGH-VOLUME DNA MICROARRAY PRODUCERS (GLASS AND PHOTOLITHOGRAPHIC), 2002
- Table 5 MICROARRAY PRODUCTION ON A VOLUME BASIS, 2002 AND 2007 (%)
- Table 6 EFFECTS OF LICENSING ON THE DNA MICROARRAY INDUSTRY
- Table 7 METHODS FOR HANDLING INTELLECTUAL PROPERTY (IP) IN MICROARRAY AND BIOCHIP PRODUCTION
- Table 8 PROTEIN MICROARRAY PRODUCERS
- Table 9 PROTEIN PRODUCERS OF BIOCHIPS, BY TYPE
- Table 10 FIRMS IN THE MICROFLUIDICS INDUSTRY
- Table 11 GLASS AND POLYMER USE IN SUBSTRATES, 2002 AND 2007 (%)
- Table 12 SUPPLIERS OF UNSPOTTED GLASS SUBSTRATES FOR BIOCHIPS, 2002
- Table 13 SUPPLIERS OF POLYMER SUBSTRATES FOR BIOCHIPS, 2002
- Table 14 CAPTIVE AND OPEN PRODUCTION OF DNA OLIGOMERS FOR MICROARRAYS, 2002 AND 2007
- Table 15 OLIGOMERIC DNA PRODUCERS, 2002
- Table 16 COMMERCIAL PRODUCERS OF CLONED DNA FOR MICROARRAYS
- Table 17 CAPTIVE VS. OPEN cDNA PRODUCTION
- Table 18 DNA LABEL SUPPLIERS, 2002
- Table 19 DIRECT DNA LABEL PRODUCERS
- Table 20 INDIRECT DNA LABEL PRODUCERS
- Table 21 STATIC BIOCHIP COMPONENTS
- Table 22 KEY CHALLENGES IN DESIGNING MICROARRAY PROBES
- Table 23 CHALLENGES TO MATERIALS USED IN MICROARRAYS
- Table 24 DNA MICROARRAY REQUIREMENTS
- Table 25 COMPARISON OF PHOTOLITHOGRAPHIC AND INKJET BIOCHIP PRODUCTION TECHNOLOGIES
- Table 26 CHALLENGES IN DETECTING PROTEINS
- Table 27 COMPARISON OF POROUS AND NONPOROUS SUBSTRATES
- Table 28 COMPARISON OF POLYMER AND GLASS SUBSTRATES FOR BIOCHIPS AND ARRAYS
- Table 29 COMPARISON OF UV AND COVALENT COATINGS FOR SUBSTRATES
- Table 30 PROBE REQUIREMENTS
- Table 31 PROBLEMS WITH PCR
- Table 32 COMPARISON OF DETECTOR TECHNOLOGY
- Table 33 CHALLENGES IN THE MICROARRAY LABELING PROCESS
- Table 34 COMPARISON OF STATIC AND DYNAMIC BIOCHIPS AND ARRAYS
- Table 35 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 36 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 37 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 38 COMPARISON OF PRESPOTTED AND UNSPOTTED MICROARRAYS
- Table 39 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 40 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 41 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 42 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 43 MATERIALS USED IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
- Table 44 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 45 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
- Table 46 GLASS SUBSTRATES BY COATING TYPE, 2002 AND 2007 (%)
- Table 47 MARKETS FOR cDNA IN GLASS MICROARRAYS, THROUGH 2007 ($ MILLIONS)
- Table 48 COMPARISON OF IN SITU AND INDEPENDENTLY SYNTHESIZED DNA OLIGOMERS
- Table 49 MARKETS FOR DNA OLIGOMERS AND AMIDITES IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
- Table 50 COMPARISON OF DIRECT AND INDIRECT LABELING
- Table 51 DIRECT AND INDIRECT LABELING, 2002, 2003 AND 2007 (%)
- Table 52 COMPARISON OF VARIOUS MARKER MOLECULE TECHNOLOGIES
- Table 53 MARKER MOLECULE MARKETS, THROUGH 2007 ($ MILLIONS)
- Table 54 INDUSTRIAL AND ACADEMIC MICROARRAY MARKETS, THROUGH 2007 (UNITS AND $ THOUSANDS)
- Table 55 COMPARISON OF THREE PROPOSED MICROARRAY APPLICATIONS: EXPRESSION PROFILING, DIAGNOSIS AND SNP DETECTION
- Table 56 REASONS FOR CORE FACILITIES
- Table 57 ACADEMIC MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND $ THOUSANDS)
- Table 58 BREAKDOWN OF COSTS FOR RUNNING A GLASS ARRAY IN ACADEMIA
- Table 59 INDUSTRIAL MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND DOLLARS IN THOUSANDS)
LIST OF FIGURES
- Summary Figure:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, 2002 AND 2007 ($ MILLIONS) - Figure 1 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, 2002 AND 2007 ($ MILLIONS)
- Figure 2 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
- Figure 3 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
- Figure 4 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, 2002, 2003 AND 2007 ($ MILLIONS)
- Figure 5 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, 2002, 2003 AND 2007 ($ MILLIONS)
- Figure 6 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, 2002, 2003 AND 2007 ($ MILLIONS)
- Figure 7 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, 2002, 2003 AND 2007 ($ MILLIONS)
- Figure 8 MATERIALS USED IN DNA MICROARRAYS, 2002 AND 2007 ($ MILLIONS)
- Figure 9 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
- Figure 10 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
- Figure 11 MARKETS FOR cDNA IN GLASS MICROARRAYS, 2002, 2003 AND 2007 ($ MILLIONS)










