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Report
[英文調查報告書]

DNA 顯微排序市場的最新動態

DNA Microarrays and Their Materials

商品編碼 : 17690
出版日期 : 2003/12

Price

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此出版品為英文撰寫

INTRODUCTION

STUDY GOALS AND OBJECTIVES

This report focuses on DNA microarrays that now play a key rolein product development in thepharmaceutical industry. Microarrays are also widely used in academic research throughout biology and biochemistry. Consequently, the markets for microarrays are effectively split between academia and industry.

DNA microarrays have their roots in the chemical methods of gene analysis that developed over the past four decades. But the transition from solution chemistry to a microarray has been confronted with a number of challenges. Coupled with the practical completion of the human genome project, there has been intense interest in characterizing the biological mechanisms that underlie human and animal physiology. While solution chemistry relied on characterizing one to perhaps a dozen genes at a time, microarrays focus on thousands of genes at once.

Needless to say, this has lead to an explosion of microarray data, and this field gives new meaning to the phrase "drowning in data." Simply put, although there is a great deal of data being generated, tools to analyze it are not keeping pace. Consequently, it has become very difficult to fully analyze microarray data. This is now one of the major issues in the field. However, it has not stopped most laboratories from both purchasing and using microarrays.

While there are a number of studies that have looked at the overall markets for microarrays, there has been a dearth of information concerning the materials used to make these goods. In some cases, material requirements for microarrays have been satisfied by using products of existing industries. These components such as substrates and probe molecules have then been incorporated into DNA microarrays.

Often, these products require modifications to make them suitable for use on a microarray, but the modifications are generally performed by the existing industry. For other materials used in microarray production, such as marker molecules, microarray requirements have forced development of new technology. (Marker molecules are used to indicate whether or not a biological target has bound to the probe molecule attached to the substrate. This process is called hybridization, and is the basis for microarray function.) Even in the field of existing technology such as the production of DNA oligomers, new producers have sprung up to fuel the DNA microarray market.

This report will help answer the following questions:

  • What are the changes taking place in the microarray industry?
  • Which companies produce microarrays, and which firms produce products used to manufacture microarrays? The substrates? The probe molecules? The marker molecules?
  • What are the important trends to watch for with regard to microarrays?

REASONS FOR DOING THIS STUDY

While a number of market forecasts relating to microarrays exist, few have covered in any detail the materials used to produce them. Not only has microarray production become a significant industry with sales in the several hundreds of millions of dollars, but the goods needed to supply microarray production have become its own industry as well.

Many estimates of microarray market size have presented a very incomplete picture, especially since they have been based more on wishful thinking than careful analysis. Some sources predicted the early demise of DNA microarrays, saying they would be replaced by protein microarrays or microfluidics devices. This report does not agree with these assessments; it covers the technology of both DNA and other types of microarrays with enough detail for readers to draw their own conclusions.

This report examines the current microarray market and the materials used to produce these goods. Readers of this report will be able to distinguish the hype associated with microarrays from the reality of the market. Readers also will be able to make plans based on current and future trends in this business, since some DNA microarrays and materials are waning in popularity and will be replaced by different technologies.

CONTRIBUTION OF THE STUDY

There have been some wild claims made for the DNA microarray market. Some forecasts have valued the market for these goods at more than $1 billion, with continued double-digit growth. This report takes a much more hardheaded look at the overall microarray market, and the materials used to produce them.

Overall, DNA microarray use will continue to increase over the next few years, but the product mix is showing some dramatic changes. These changes may affect suppliers of materials to the microarray market more than the microarray manufacturers, since the manufacturers' first concern is whether or not their microarrays will be marketable.

With this information, readers with business interests can make sound judgments regarding marketing strategies, investment decisions, or strategic plans concerning the marketing of microarrays. This report has been written to be readily accessible for readers with a business background. But accuracy of the technological aspects of microarrays has not been sacrificed.

SCOPE AND FORMAT

This report focuses on DNA microarrays and the materials used to produce them including substrates, probe molecules and marker molecules. Microarrays are widely used in the pharmaceutical industry and in academia. This report briefly covers their uses in these broad applications, and details the costs of actually using them.

The report does not include market evaluations of antiterrorist applications, clinical applications, or other environmental detection applications that may use microfluidics devices, protein microarrays or DNA microarrays. Protein microarrays and microfluidics devices are not considered to be commercially important at this time. Thus, the report covers the industry devoted to producing these goods and some of the technology behind them. It does not cover in much detail the materials used to produce either microfluidics devices or protein microarrays. Therefore, most of the report focuses heavily on DNA microarrays.

The report is broken into four sections:

  • an industry structure section that details the makeup of the firms that produce microarrays and those that produce materials used in microarray production, along with selected company profiles
  • an extensive technology overview that covers the relevant technology of DNA microarray production and materials, along with comparisons of various technologies
  • a thorough description of the available products for DNA microarrays, and the materials used to produce them
  • a concluding market applications section that discusses some of the relevant trends in the use and costs of DNA microarrays.

METHODOLOGY AND INFORMATION SOURCES

This report is the end result of five months of concerted effort by the author. Primary information sources were interviews with several dozen people in industry, academia and the government. Many of the people interviewed are recognized authorities in the field, and provided invaluable assistance and insight, and I would like to thank all who took the time to speak with me for their help with this project.

This study was not commissioned by any corporation or individual, and is thus as objective as is possible.

Secondary sources include a number of publications issued by the federal government, as well as items from the Internet, corporate literature and peer-reviewed publications.

Any time an estimate has been made, the underlying assumptions are discussed. Thus, if readers choose to interpret the raw data in a differing manner, it is possible to do so. Dollar amounts are in constant 2002 dollars, and average annual growth rates (AAGRs) are calculated using standard tables.

TABLE OF CONTENTS

INTRODUCTION

    • STUDY GOALS AND OBJECTIVES
    • REASONS FOR DOING THIS STUDY
    • CONTRIBUTION OF THE STUDY
    • SCOPE AND FORMAT
    • METHODOLOGY AND INFORMATION SOURCES
    • AUTHOR'S CREDENTIALS
    • RELATED PUBLICATIONS
    • BCC ONLINE SERVICES
    • DISCLAIMER

SUMMARY

  • Summary Table:
    U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, THROUGH 2007 ($ MILLIONS)
  • Summary Figure:
    U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, 2002 AND 2007 ($ MILLIONS)

INDUSTRY STRUCTURE

    • INTRODUCTION
      • INTRODUCTION (CONTINUED)
    • MICROARRAYS AND MICROFLUIDICS DEVICES
      • PRODUCERS OF DNA BIOCHIPS AND MICROARRAYS: PHOTOLITHOGRAPHIC CHIPS AND GLASS ARRAYS
        • Photolithographic Microarrays
          • Affymetrix Substrates
          • Affymetrix Biomolecules
          • Sequence Information of Affymetrix Biomolecules
          • Affymetrix Marker Molecules
          • Overall Production Costs
          • Photolithographic Microarray Developers
          • Photolithographic Microarray Processors
  • Table 1 FIRMS OFFERING AFFYMETRIX SLIDE PROCESSING
      • THE GLASS ARRAY INDUSTRY
        • A Brief History of Glass Microarrays
        • Spotted and Unspotted Glass Arrays
          • Spotted and Unspotted Glass Arrays (Continued)
          • Spotted Arrays
  • Table 2 SPOTTED DNA MICROARRAY MANUFACTURERS, 2002
          • Unspotted Arrays
            • Unspotted Arrays (Continued)
  • Table 3 VENDORS OF SUPPLIES AND EQUIPMENT TO THE UNSPOTTED MICROARRAY MARKET
        • Microarray Production by Volume: High-volume Producers
  • Table 4 HIGH-VOLUME DNA MICROARRAY PRODUCERS (GLASS AND PHOTOLITHOGRAPHIC), 2002
        • The Low-volume Microarray Industry
  • Table 5 MICROARRAY PRODUCTION ON A VOLUME BASIS, 2002 AND 2007 (%)
        • Licensing in the Microarray Industry
          • A Brief History of Licensing in the Microarray Industry
          • Licensing Involving Fluorophores
          • Effects of Licensing on the U.S. Industry
  • Table 6 EFFECTS OF LICENSING ON THE DNA MICROARRAY INDUSTRY
            • Barrier to Foreign Competition
            • Barriers to Entry of New Technology
            • Decreased Competition
            • Intellectual Property Involving Biomolecules
  • Table 7 METHODS FOR HANDLING INTELLECTUAL PROPERTY (IP) IN MICROARRAY AND BIOCHIP PRODUCTION
            • Sequence Information Producers
            • Costs
            • Litigation Possibilities
            • Overall Use
      • THE PROTEIN CHIP INDUSTRY
  • Table 8 PROTEIN MICROARRAY PRODUCERS
  • Table 9 PROTEIN PRODUCERS OF BIOCHIPS, BY TYPE
      • THE MICROFLUIDICS CHIP INDUSTRY
  • Table 10 FIRMS IN THE MICROFLUIDICS INDUSTRY
    • MATERIALS FOR MICROARRAYS AND MICROFLUIDICS DEVICES
      • MATERIALS FOR MICROARRAYS .. (CONTINUED)
      • BIOCHIP AND MICROARRAY SUBSTRATES
        • Glass Substrates
  • Table 11 GLASS AND POLYMER USE IN SUBSTRATES, 2002 AND 2007 (%)
          • Unspotted Substrate Producers
  • Table 12 SUPPLIERS OF UNSPOTTED GLASS SUBSTRATES FOR BIOCHIPS, 2002
          • The Spotted Glass Substrate Industry
            • History of the Agreement Between Amersham and Surmodics
        • Polymer Substrates
  • Table 13 SUPPLIERS OF POLYMER SUBSTRATES FOR BIOCHIPS, 2002
        • Silicon Substrates
      • BIOMOLECULES
          • DNA Producers
          • DNA Oligomers
  • Table 14 CAPTIVE AND OPEN PRODUCTION OF DNA OLIGOMERS FOR MICROARRAYS, 2002 AND 2007
          • Open Production of DNA Oligomers in Glass Arrays
            • A Brief History of DNA Oligomer Production
  • Table 15 OLIGOMERIC DNA PRODUCERS, 2002
            • Oligo Pricing
            • Purified Oligomers
            • Oligomer Modifications
          • Production of cDNA in the Glass Array Industry
  • Table 16 COMMERCIAL PRODUCERS OF CLONED DNA FOR MICROARRAYS
  • Table 17 CAPTIVE VS. OPEN cDNA PRODUCTION
      • MARKER MOLECULES
  • Table 18 DNA LABEL SUPPLIERS, 2002
        • Fluorophore Labeling Types
          • Direct Label Producers
  • Table 19 DIRECT DNA LABEL PRODUCERS
          • Indirect Label Producers
  • Table 20 INDIRECT DNA LABEL PRODUCERS
COMPANY PROFILES
    • AFFYMETRIX, INC.
    • GENISPHERE, INC.
    • XENOPORE CORP.
    • SURMODICS
    • IDT
    • ENZO LIFE SCIENCES, INC.
    • ICONIX PHARMACEUTICALS, INC.
    • INCYTE CORP.
    • AGILENT TECHNOLOGIES
    • AMERSHAM BIOSCIENCES
    • PERKINELMER
    • QIAGEN GMBH
    • SIGMA-GENOSYS
    • BD BIOSCIENCES CLONTECH
    • CORNING, INC.
    • GENICON SCIENCES CORP.

TECHNOLOGY OVERVIEW

    • WHAT IS A BIOCHIP?
    • STATIC BIOCHIPS
      • WHAT A STATIC BIOCHIP IS
  • Table 21 STATIC BIOCHIP COMPONENTS
        • Substrates
        • Probe Molecules
        • Marker Molecules
      • WHAT A DNA MICROARRAY DOES
        • What a DNA Microarray Does (Continued)
        • Quantification Using Microarrays
        • The Larger Gene Expression Picture
          • The Larger Gene Expression Picture (Continued)
          • The Larger Gene Expression Picture (Continued)
          • The Larger Gene Expression Picture (Continued)
        • Microarray Design
  • Table 22 KEY CHALLENGES IN DESIGNING MICROARRAY PROBES
          • Base Pair Mismatches
          • Poor Binding
          • Hybridization
          • Variable Signal Strengths
          • Interpretation of Microarrays
          • Intramicroarray Variability
          • Intermicroarray Variability
          • Variations in Analysis
        • Challenges to Microarray Materials
  • Table 23 CHALLENGES TO MATERIALS USED IN MICROARRAYS
          • Substrates
          • Probes
          • Marker Molecules
        • DNA Microarray Performance Requirements
  • Table 24 DNA MICROARRAY REQUIREMENTS
          • Firm Tethering
          • Unhindered Binding
          • Using Larger DNA Molecules
          • No Cross-contamination
          • Unreactive Surface
        • Current DNA Microarrays
      • PHOTOLITHOGRAPHY TECHNOLOGY
        • Photolithography Technology (Continued)
        • The Incomplete Reaction Problem
        • Probe Design
        • Development Trends
      • GLASS ARRAYS
        • Amersham's Coating Technology
        • Agilent Technology
        • Probe Technology
      • COMPARISON OF INKJET AND PHOTOLITHOGRAPHIC TECHNOLOGY
  • Table 25 COMPARISON OF PHOTOLITHOGRAPHIC AND INKJET BIOCHIP PRODUCTION TECHNOLOGIES
        • Production Rates
        • Requires Masks
        • Adaptability
        • Cross-contamination
        • Feature Size
        • Probe Accessibility
        • Probe Purity
        • Overall Performance
        • Market Acceptance
      • PROTEIN MICROARRAYS
  • Table 26 CHALLENGES IN DETECTING PROTEINS
        • Difficult to Detect
        • Complex in Formation
        • Lack of Binding
        • Posttranslational Modification
        • Costs
        • Competing Technologies
        • Summary
    • MATERIALS TECHNOLOGY
      • SUBSTRATES
        • A Brief History of Substrate Development
  • Table 27 COMPARISON OF POROUS AND NONPOROUS SUBSTRATES
          • Materials
          • Coatings
          • Control of Spot Size
          • Diffusion Mechanisms
        • Glass and Polymer Substrates
  • Table 28 COMPARISON OF POLYMER AND GLASS SUBSTRATES FOR BIOCHIPS AND ARRAYS
          • High-throughput Applicability
          • Can Be Used with Photolithography or Inkjet?
          • Surface Smoothness and Machinability
          • Easily Coated
        • Types of Coatings
        • The Importance of Coatings
        • Relevance of Coatings in the Courtroom
        • Glass Coating Technology for Substrates
          • UV Coatings
          • Covalent Coatings
  • Table 29 COMPARISON OF UV AND COVALENT COATINGS FOR SUBSTRATES
          • Utility with Production Technologies
          • Free Radicals
          • Monolayers
          • Spacer Requirements
          • Patents
        • Markets
      • PROBE TECHNOLOGY
  • Table 30 PROBE REQUIREMENTS
        • Selectivity
        • Tight Binding
          • Ease of Manufacture
        • cDNA Technology
  • Table 31 PROBLEMS WITH PCR
          • Time Consuming
          • Breakdown
          • Accuracy
          • Expensive
            • Sensitivity
            • Selectivity
      • MARKER TECHNOLOGY
  • Table 32 COMPARISON OF DETECTOR TECHNOLOGY
        • Accuracy
        • Sensitivity
        • Ease of Use
        • Challenges in Labeling DNA Microarrays
  • Table 33 CHALLENGES IN THE MICROARRAY LABELING PROCESS
          • Specific Binding
          • Must Fluoresce or Signal in Proportion to Binding
          • Must Not Hinder Hybridization
          • Must Be Stable
          • Must Emit a Clean Signal
      • MICROFLUIDICS TECHNOLOGY
  • Table 34 COMPARISON OF STATIC AND DYNAMIC BIOCHIPS AND ARRAYS
      • USE
      • FLOW
      • SUBSTRATES
      • APPLICATIONS
      • EASE OF USE
        • Ease of Use (Continued)

PRODUCTS

    • INTRODUCTION
    • THE OVERALL BIOCHIP MARKET
  • Table 35 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 1 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, 2002 AND 2007 ($ MILLIONS)
      • THE OVERALL BIOCHIP MARKET (CONTINUED)
    • DNA MICROARRAYS
  • Table 36 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 2 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
      • DNA GLASS ARRAYS
  • Table 37 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 3 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
        • Industry Trends
          • Industry Trends (Continued)
  • Table 38 COMPARISON OF PRESPOTTED AND UNSPOTTED MICROARRAYS
          • Ease of Use
          • Production Methodology
          • Costs
        • Unspotted Arrays by Market
  • Table 39 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 4 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, 2002, 2003 AND 2007 ($ MILLIONS)
        • Microarrays by Type
  • Table 40 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 5 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, 2002, 2003 AND 2007 ($ MILLIONS)
        • CDNA and Oligo Microarrays by Market
  • Table 41 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 6 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, 2002, 2003 AND 2007 ($ MILLIONS)
  • Table 42 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 7 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, 2002, 2003 AND 2007 ($ MILLIONS)
    • MATERIALS USED IN MICROARRAYS
  • Table 43 MATERIALS USED IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
  • Figure 8 MATERIALS USED IN DNA MICROARRAYS, 2002 AND 2007 ($ MILLIONS)
      • SUBSTRATES
        • Coated and Uncoated Substrates
  • Table 44 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 9 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
        • Glass Substrates by Coating Type
  • Table 45 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
  • Figure 10 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
  • Table 46 GLASS SUBSTRATES BY COATING TYPE, 2002 AND 2007 (%)
      • BIOMOLECULES
        • DNA Probes by Type
          • CDNA
            • CDNA by Markets: Pharmaceutical
            • Academic Markets
  • Table 47 MARKETS FOR cDNA IN GLASS MICROARRAYS, THROUGH 2007 ($ MILLIONS)
  • Figure 11 MARKETS FOR cDNA IN GLASS MICROARRAYS, 2002, 2003 AND 2007 ($ MILLIONS)
        • Oligomeric DNA
          • Oligomeric DNA by Production Methodology
  • Table 48 COMPARISON OF IN SITU AND INDEPENDENTLY SYNTHESIZED DNA OLIGOMERS
        • Production Technology
          • Oligomer Length
            • Accuracy and Quality Control
            • Cross-contamination
            • Production Costs
  • Table 49 MARKETS FOR DNA OLIGOMERS AND AMIDITES IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
        • Protein Probes
      • MARKER MOLECULES
  • Table 50 COMPARISON OF DIRECT AND INDIRECT LABELING
  • Table 51 DIRECT AND INDIRECT LABELING, 2002, 2003 AND 2007 (%)
        • Marker Molecules by Technology
  • Table 52 COMPARISON OF VARIOUS MARKER MOLECULE TECHNOLOGIES
        • Stability
        • Instrumentation
        • Costs
  • Table 53 MARKER MOLECULE MARKETS, THROUGH 2007 ($ MILLIONS)

MARKET APPLICATIONS

    • INTRODUCTION
    • DNA MICROARRAY MARKETS
  • Table 54 INDUSTRIAL AND ACADEMIC MICROARRAY MARKETS, THROUGH 2007 (UNITS AND $ THOUSANDS)
      • MICROARRAY APPLICATIONS
  • Table 55 COMPARISON OF THREE PROPOSED MICROARRAY APPLICATIONS: EXPRESSION PROFILING, DIAGNOSIS AND SNP DETECTION
        • Current Use
        • Technology Developments
        • Diagnostics
          • Theoretical Underpinnings of Microarray Applications
            • Expression Profiling
            • SNPs
            • Diagnostics
    • THE ACADEMIC RESEARCH MARKET
      • MICROARRAY PRODUCTION IN ACADEMIA
  • Table 56 REASONS FOR CORE FACILITIES
          • Microarray Production in Academia (Continued)
          • Microarray Production in Academia (Continued)
        • Numbers of Core Facilities
  • Table 57 ACADEMIC MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND $ THOUSANDS)
        • Pricing of Arrays in Academia
        • Array Costs
  • Table 58 BREAKDOWN OF COSTS FOR RUNNING A GLASS ARRAY IN ACADEMIA
          • Substrate/Oligomer Costs
          • Processing Costs
          • Amplification
          • Hybridization
          • DNA Synthesis Kit
          • Marker Molecules
          • Photolithographic
          • Glass Arrays
      • MICROARRAY FUNDING
        • The Catch-22 of NIH Funding
    • INDUSTRIAL MARKET APPLICATIONS
      • TYPES OF MICROARRAYS USED BY INDUSTRY: GLASS AND PHOTOLITHOGRAPHIC ARRAYS
  • Table 59 INDUSTRIAL MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND DOLLARS IN THOUSANDS)
        • Pricing of Microarrays Used in Industry
          • Photolithographic Arrays
          • Glass Arrays
          • Processing Costs
          • Trends in Microarray Use
            • Trends in Microarray Use (Continued)

 LIST OF TABLES

Summary Table:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, THROUGH 2007 ($ MILLIONS)
Table 1 FIRMS OFFERING AFFYMETRIX SLIDE PROCESSING
Table 2 SPOTTED DNA MICROARRAY MANUFACTURERS, 2002
Table 3 VENDORS OF SUPPLIES AND EQUIPMENT TO THE UNSPOTTED MICROARRAY MARKET
Table 4 HIGH-VOLUME DNA MICROARRAY PRODUCERS (GLASS AND PHOTOLITHOGRAPHIC), 2002
Table 5 MICROARRAY PRODUCTION ON A VOLUME BASIS, 2002 AND 2007 (%)
Table 6 EFFECTS OF LICENSING ON THE DNA MICROARRAY INDUSTRY
Table 7 METHODS FOR HANDLING INTELLECTUAL PROPERTY (IP) IN MICROARRAY AND BIOCHIP PRODUCTION
Table 8 PROTEIN MICROARRAY PRODUCERS
Table 9 PROTEIN PRODUCERS OF BIOCHIPS, BY TYPE
Table 10 FIRMS IN THE MICROFLUIDICS INDUSTRY
Table 11 GLASS AND POLYMER USE IN SUBSTRATES, 2002 AND 2007 (%)
Table 12 SUPPLIERS OF UNSPOTTED GLASS SUBSTRATES FOR BIOCHIPS, 2002
Table 13 SUPPLIERS OF POLYMER SUBSTRATES FOR BIOCHIPS, 2002
Table 14 CAPTIVE AND OPEN PRODUCTION OF DNA OLIGOMERS FOR MICROARRAYS, 2002 AND 2007
Table 15 OLIGOMERIC DNA PRODUCERS, 2002
Table 16 COMMERCIAL PRODUCERS OF CLONED DNA FOR MICROARRAYS
Table 17 CAPTIVE VS. OPEN cDNA PRODUCTION
Table 18 DNA LABEL SUPPLIERS, 2002
Table 19 DIRECT DNA LABEL PRODUCERS
Table 20 INDIRECT DNA LABEL PRODUCERS
Table 21 STATIC BIOCHIP COMPONENTS
Table 22 KEY CHALLENGES IN DESIGNING MICROARRAY PROBES
Table 23 CHALLENGES TO MATERIALS USED IN MICROARRAYS
Table 24 DNA MICROARRAY REQUIREMENTS
Table 25 COMPARISON OF PHOTOLITHOGRAPHIC AND INKJET BIOCHIP PRODUCTION TECHNOLOGIES
Table 26 CHALLENGES IN DETECTING PROTEINS
Table 27 COMPARISON OF POROUS AND NONPOROUS SUBSTRATES
Table 28 COMPARISON OF POLYMER AND GLASS SUBSTRATES FOR BIOCHIPS AND ARRAYS
Table 29 COMPARISON OF UV AND COVALENT COATINGS FOR SUBSTRATES
Table 30 PROBE REQUIREMENTS
Table 31 PROBLEMS WITH PCR
Table 32 COMPARISON OF DETECTOR TECHNOLOGY
Table 33 CHALLENGES IN THE MICROARRAY LABELING PROCESS
Table 34 COMPARISON OF STATIC AND DYNAMIC BIOCHIPS AND ARRAYS
Table 35 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 36 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 37 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 38 COMPARISON OF PRESPOTTED AND UNSPOTTED MICROARRAYS
Table 39 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 40 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 41 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 42 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 43 MATERIALS USED IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
Table 44 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 45 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, THROUGH 2007 (THOUSAND UNITS AND $ MILLIONS)
Table 46 GLASS SUBSTRATES BY COATING TYPE, 2002 AND 2007 (%)
Table 47 MARKETS FOR cDNA IN GLASS MICROARRAYS, THROUGH 2007 ($ MILLIONS)
Table 48 COMPARISON OF IN SITU AND INDEPENDENTLY SYNTHESIZED DNA OLIGOMERS
Table 49 MARKETS FOR DNA OLIGOMERS AND AMIDITES IN DNA MICROARRAYS, THROUGH 2007 ($ MILLIONS)
Table 50 COMPARISON OF DIRECT AND INDIRECT LABELING
Table 51 DIRECT AND INDIRECT LABELING, 2002, 2003 AND 2007 (%)
Table 52 COMPARISON OF VARIOUS MARKER MOLECULE TECHNOLOGIES
Table 53 MARKER MOLECULE MARKETS, THROUGH 2007 ($ MILLIONS)
Table 54 INDUSTRIAL AND ACADEMIC MICROARRAY MARKETS, THROUGH 2007 (UNITS AND $ THOUSANDS)
Table 55 COMPARISON OF THREE PROPOSED MICROARRAY APPLICATIONS: EXPRESSION PROFILING, DIAGNOSIS AND SNP DETECTION
Table 56 REASONS FOR CORE FACILITIES
Table 57 ACADEMIC MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND $ THOUSANDS)
Table 58 BREAKDOWN OF COSTS FOR RUNNING A GLASS ARRAY IN ACADEMIA
Table 59 INDUSTRIAL MARKETS FOR MICROARRAYS (INCLUDING PROCESSING COSTS), THROUGH 2007 (UNITS AND DOLLARS IN THOUSANDS)  

LIST OF FIGURES

Summary Figure:
U.S. MARKETS FOR DNA MICROARRAYS AND MICROARRAY MATERIALS, 2002 AND 2007 ($ MILLIONS)
Figure 1 MARKETS FOR DNA AND PROTEIN MICROARRAYS AND MICROFLUIDICS DEVICES, 2002 AND 2007 ($ MILLIONS)
Figure 2 PHOTOLITHOGRAPHY AND GLASS MICROARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
Figure 3 SPOTTED AND UNSPOTTED GLASS ARRAY MARKETS, 2002, 2003 AND 2007 ($ MILLIONS)
Figure 4 UNSPOTTED GLASS MICROARRAYS IN INDUSTRY AND ACADEMIA, 2002, 2003 AND 2007 ($ MILLIONS)
Figure 5 GLASS MICROARRAYS BY TYPE: cDNA AND OLIGO, 2002, 2003 AND 2007 ($ MILLIONS)
Figure 6 cDNA AND OLIGO GLASS MICROARRAYS IN INDUSTRY, 2002, 2003 AND 2007 ($ MILLIONS)
Figure 7 cDNA AND OLIGO GLASS MICROARRAYS USED IN ACADEMIC RESEARCH, 2002, 2003 AND 2007 ($ MILLIONS)
Figure 8 MATERIALS USED IN DNA MICROARRAYS, 2002 AND 2007 ($ MILLIONS)
Figure 9 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
Figure 10 GLASS SUBSTRATES BY COATING, AS USED IN GLASS ARRAYS, 2002 AND 2007 ($ MILLIONS)
Figure 11 MARKETS FOR cDNA IN GLASS MICROARRAYS, 2002, 2003 AND 2007 ($ MILLIONS)
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此出版品為英文撰寫

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[英文調查報告書]
DNA 顯微排序市場的最新動態
DNA Microarrays and Their Materials

出版商 : BCC Research BCC Research
代理商 : Global Information, Inc. Global Information, Inc.

US $ 4,430 (Hard Copy)
US $ 4,430 (PDF by E-mail (Single User License))
商品編碼 : 17690

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