蛋白質晶片的未來

INTRODUCTION

STUDY GOALS AND OBJECTIVES

For research, diagnostics and therapeutic purposes, the attachment of proteins to a surface in the ordered manner of an array so that more than one protein binds at a time is a burgeoning field because of the many possible applications. This technology is similar to that of the DNA microarray. Applications include protein expression profiling, drug discovery, and diagnostics. This study examines protein array technologies ¾ what is available now and what is being developed. The report also predicts how the technologies are likely to grow worldwide in the next five years (through 2007). An important part of the report analyzes patent trends and other trends that are vital to the success of these new technologies.

REASONS FOR DOING THE STUDY

The invention of protein microarray technology, also called protein biochip technology, allows more than one protein binding interaction at a time and improves upon the current state-of-the-art-protein immunoassay technology where only one protein binds at a time. Interestingly, the term protein chip is trademarked by Lumicyte, Inc. There are many proteome projects, which study the protein complements of genomes, as a result of the sequencing of the human genome and the genomes of other organisms. The increase in the number of known proteins and potential number of new proteins, due to the numerous genome and proteome projects, increases the demand for tools such as protein arrays. The arrays allow for simultaneous detection of multiple protein interactions and protein expression levels.

Following on the heels of the DNA microarray industry, many companies have entered the protein array field, and the number of players involved with technology development is increasing rapidly. Due to the technical challenges of constructing functional protein arrays, such as the adherence of protein to a surface while maintaining functionality, the number of proteins that can be arrayed, and the detection of binding interactions, many academic, government, and industry players are developing different technologies. The different potential research, diagnostic, and therapeutic applications also drive the demand for more than one protein array technology.

AUDIENCE FOR THE REPORT

This report is directed at decision-makers in each industry segment, as well as individuals and organizations considering investing in drug discovery or drug discovery technology. These people include, but are not limited to, venture capitalists, merger and acquisition executives, market and product management professionals, chief scientists and technical officers, equipment manufacturers, and reagent suppliers.

SCOPE AND FORMAT

This report is a tool that analyzes the emerging worldwide industry in protein arrays. The section following this introduction provides a summary of the report and its conclusions. An overview of the market and a brief discussion of the relevant scientific principles follow the summary. The ensuing sections analyze government regulations, current and future market trends, and the importance of each new method of research to the overall market. There is also an analysis of patents and their importance to the industry.

The study considers current and new protein array technologies for research and development. The appendix of the report contains a company directory.

METHODOLOGY AND INFORMATION SOURCES

The material for this report was gathered from interviews with individuals in the industry, as well as a thorough review of technology gathered from secondary sources. These sources include company annual, 10K, and 10Q reports, company literature, trade literature, trade associations, and online sources.

Projections were based on such estimates as the current number of end users, funding levels, potential end users, likely unit prices, and rates of consumption. Final projections are based on the analysis of information from primary and secondary sources. All dollar projections are presented in year 2002 constant dollars.

INTRODUCTION

• STUDY GOALS AND OBJECTIVES
• REASONS FOR DOING THE STUDY
• AUDIENCE FOR THE REPORT
• SCOPE AND FORMAT
• METHODOLOGY AND INFORMATION SOURCES
• BCC INFORMATION AND RELATED BCC STUDIES
• ANALYST CREDENTIALS
• DISCLAIMER
• BCC ON-LINE SERVICES

EXECUTIVE SUMMARY

Summary Table:
WORLDWIDE PROTEIN ARRAY TECHNOLOGY SALES BY MARKET SEGMENT, THROUGH 2007 ($ MILLIONS)

Summary Figure:
WORLDWIDE PROTEIN ARRAY TECHNOLOGY SALES BY MARKET SEGMENT, 2000-2007 ($ MILLIONS)

OVERVIEW

• WHICH IS THE CHICKEN, WHICH IS THE EGG: PROTEOMICS OR PROTEIN ARRAYS?
• ARRAY-BASED PROTEOMICS GLOSSARY
  • ARRAY-BASED PROTEOMICS GLOSSARY (CONTINUED)
  • ARRAY-BASED PROTEOMICS GLOSSARY (CONTINUED)
  • ARRAY-BASED PROTEOMICS GLOSSARY (CONTINUED)
  • ARRAY-BASED PROTEOMICS GLOSSARY (CONTINUED)

PROTEIN ARRAY TECHNOLOGY

• SURFACES
• ATTACHMENT CHEMISTRY
• ARRAYING DEVICES
• DETECTION AND ANALYSIS ON MICROARRAYS
• CAPTURE MOLECULES

Table 1 PROTEIN CAPTURE MOLECULES AND TARGETS

• PROTEIN PRODUCTION FOR PROTEIN ARRAYS
• PROTEIN ARRAY APPLICATIONS
  • DIAGNOSTICS
  • PROTEOME RESEARCH
  • DRUG DISCOVERY AND SCREENING

GOVERNMENT REGULATIONS

• DRUG DISCOVERY PROCESS
  • FDA REGULATORY OVERVIEW
    • Target Discovery and Drug Identification
    • Preclinical Testing and Submission of an IND
    • Clinical Trials
    • Submission of an NDA
    • Post-FDA Approval
    • Noncompliance
  • OTHER AGENCY REGULATIONS
  • REGULATORY COSTS
  • REGULATORY BENEFITS
  • RESEARCH AND DEVELOPMENT SPENDING

Table 2 R&D SPENDING IN THE GLOBAL PHARMACEUTICAL INDUSTRY, 1980-2002 ($ MILLIONS)

• Distribution of Research Costs

Table 3 DISTRIBUTION OF DRUG RESEARCH COSTS

• Target Discovery Costs and Benefits
• REGULATORY ENVIRONMENT AND R&D COST CUTTING
  • Preliminary Stage R&D Cost Reduction
• NEW DRUG APPROVALS

Table 4 DRUGS APPROVED BY THE FDA, 1993-2002 (# DRUGS)

• CLINICAL DIAGNOSTICS
  • FEDERAL REGULATION OF MOLECULAR DIAGNOSTICS
    • Analyte-Specific Reagent Regulations
      • Analyte-Specific Reagent Regulations (Continued)

PROTEOME CONSORTIUMS

• BIOPATHWAYS CONSORTIUM
  • BIOLOGICAL PATHWAY EXCHANGE
• PLASMA PROTEOME INSTITUTE
• HUMAN PROTEOME ORGANIZATION
  • THE PROTEOMICS STANDARDS INITIATIVE
• THE PROTEOME SOCIETY

PROTEIN ARRAY TECHNOLOGY MARKET

• MARKET SEGMENTS

Table 5 PROTEIN ARRAY TECHNOLOGY COMPANIES AND MARKET SHARES, BY CATEGORY, 2002

• TECHNOLOGY TRENDS
• MARKET FORECASTS
  • SALES AND MARKET SHARE
  • GROWTH RATE

Table 6 WORLDWIDE PROTEIN ARRAY TECHNOLOGY SALES BY CATEGORY, THROUGH 2007 ($ MILLIONS)

• DISTRIBUTION OF COMPANIES BY SEGMENT

Table 7 WORLDWIDE DISTRIBUTION OF PROTEIN ARRAY TECHNOLOGY COMPANIES BY CATEGORY, 2002

• COMPANY PRODUCT LAUNCHES

Table 8 COMPANIES WORLDWIDE THAT LAUNCHED PROTEIN ARRAY TECHNOLOGY PRODUCTS, BY CATEGORY, 1999-2002

Table 9 PROTEIN ARRAY TECHNOLOGY PRODUCT LAUNCHES, BY CATEGORY, 2002 (%)

• ANTIBODY ARRAYS

Table 10 COMPANIES THAT LAUNCHED ANTIBODY ARRAY PRODUCTS, 1999-2002

• SALES

Table 11 WORLDWIDE ANTIBODY ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)

Figure 1 WORLDWIDE ANTIBODY ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)

• ANTIBODY ARRAY PLAYERS

Table 12 ANTIBODY ARRAY TECHNOLOGY PRODUCT LAUNCHES, BY COMPANY, 2000-2002

• ANTIBODY ARRAY TECHNOLOGY

Table 13 SUMMARY OF ANTIBODY ARRAY TECHNOLOGY FEATURES, BY COMPANY

• Surface Materials

Table 14 ANTIBODY ARRAY SURFACE MATERIAL USE, BY TYPE, 2002

• Detection Methods

Table 15 ANTIBODY ARRAY DETECTION METHOD USE BY TYPE, 2002

• ANTIBODY ARRAY MARKET SHARE

Table 16 ANTIBODY ARRAY TECHNOLOGY COMPANY MARKET SHARE, 2002

Figure 2 ANTIBODY ARRAY TECHNOLOGY COMPANY MARKET SHARE, 2002 (%)

• Schleicher & Schuell Bioscience, Inc.
• RayBiotech
• Panomics
• Pierce Chemical Company
• BD Clontech
• Hypromatrix
• Milagen
• OTHER ANTIBODY ARRAY DEVELOPMENTS
• TYPES/APPLICATIONS OF ANTIBODY ARRAYS

Table 17 APPLICATIONS/TYPES OF ANTIBODY ARRAY TECHNOLOGY, BY COMPANY

• PEPTIDE BIOCHIP ARRAYS
  • SALES

Table 18 WORLDWIDE PEPTIDE BIOCHIP ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)

Figure 3 WORLDWIDE PEPTIDE BIOCHIP ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)

Table 19 PEPTIDE ARRAY PRODUCT LAUNCHES, 1999-2002

• PEPTIDE CHIP TECHNOLOGY PLAYERS

Table 20 PEPTIDE BIOCHIP TECHNOLOGY LAUNCHES BY COMPANY, 2000-2004

• PEPTIDE BIOCHIP TECHNOLOGY

Table 21 PEPTIDE BIOCHIP TECHNOLOGY FEATURES, BY COMPANY

• Surface Materials

Table 22 PEPTIDE ARRAY SURFACE MATERIAL USE, BY COMPANY

• Detection Methods

Table 23 PEPTIDE ARRAY DETECTION METHOD BY COMPANY

• PROTEIN BIOCHIP ARRAYS
  • SALES

Table 24 WORLDWIDE PROTEIN BIOCHIP ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)

Figure 4 WORLDWIDE PROTEIN BIOCHIP ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)

Table 25 PROTEIN BIOCHIP TECHNOLOGY COMPANIES

• PROTEIN BIOCHIP ARRAY PLAYERS

Table 26 COMPANIES THAT LAUNCHED PROTEIN BIOCHIPS, 1999-2002

Table 27 PROTEIN BIOCHIP PRODUCT LAUNCHES BY COMPANY, 1999-2002

• PROTEIN BIOCHIP ARRAY TECHNOLOGY

Table 28 PROTEIN BIOCHIP ARRAY PRODUCTS/SERVICES FEATURES BY COMPANY

Table 28 (CONTINUED)

• PROTEIN BIOCHIP ARRAY MARKET SHARE

Table 29 PROTEIN BIOCHIP ARRAY TECHNOLOGY COMPANY MARKET SHARES, 2002 (%)

Figure 5 PROTEIN BIOCHIP ARRAY TECHNOLOGY COMPANY MARKET SHARES, 2002 (%)

• COMPANIES DEVELOPING PROTEIN BIOCHIP ARRAY TECHNOLOGY

Table 30 COMPANIES WITH PROTEIN BIOCHIP ARRAY TECHNOLOGY IN DEVELOPMENT

Table 30 (CONTINUED)

Table 30 (CONTINUED)

• Molecular Staging, Inc.
• Somalogic, Inc.
• Zeptosens AG
• Protein Biochip Array Surface Materials

Table 31 PROTEIN BIOCHIP ARRAY SURFACE MATERIAL USE, BY TYPE, 2002

Table 32 PROTEIN BIOCHIP ARRAY SURFACE MATERIAL DESCRIPTION, BY COMPANY

• Protein Biochip Array Detection Technology

Table 33 PROTEIN BIOCHIP ARRAY DETECTION METHOD USE BY TYPE, 2002

Table 34 PROTEIN BIOCHIP ARRAY DETECTION METHOD DESCRIPTION, BY COMPANY

Table 34 (CONTINUED)

• Randox Laboratories, Ltd.
• SOLUTION BEAD/PARTICLE PROTEIN ARRAYS

Table 35 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)

Figure 6 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)

• SOLUTION BEAD/PARTICLE TECHNOLOGY PLAYERS

Table 36 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY COMPANIES

• SOLUTION BEAD/PARTICLE TECHNOLOGY PLAYERS

Table 37 SUMMARY OF SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY FEATURES BY COMPANY

• Nanoplex Nanobar
• Polymer Bead/Semi-Conductor Core Shell
• Smartbead™

Table 38 SOLUTION BEAD/PARTICLE PROTEIN ARRAY MATERIAL TECHNOLOGY USE BY TYPE, 2002

Table 39 SOLUTION BEAD/PARTICLE PROTEIN ARRAY DETECTION TECHNOLOGY USE BY TYPE, 2002

• SOLUTION BEAD/PARTICLE ARRAY MARKET SHARE

Table 40 SOLUTION BEAD/PARTICLE ARRAY COMPANY MARKET SHARE, 2002

• Luminex Corp.
  • Solution Bead/Particle Collaborators

Table 41 LUMINEX RESEARCH/DRUG DISCOVERY PARTNERS AND APPLICATIONS

Table 42 LUMINEX DIAGNOSTIC PARTNERS AND APPLICATIONS

Table 43 SOLUTION BEAD/PARTICLE COLLABORATIONS, BY APPLICATION AREA, 2002

• Biochip versus Bead/Particle Protein Array Study
  • Results
• Luminex Venture FDA-Approved Products
  • Luminex Venture FDA-Approved Products (Continued)

PROTEIN ARRAY APPLICATION MARKETS

Table 44 PROTEIN ARRAY APPLICATION SECTOR SALES, THROUGH 2007 ($ MILLIONS)

• RESEARCH PROTEIN ARRAY TECHNOLOGY SECTOR

Table 45 RESEARCH PROTEIN ARRAY TECHNOLOGY SALES BY CATEGORY, THROUGH 2007 ($ MILLIONS)

• Antibody Array Technology Research Market Players

Table 46 ANTIBODY PROTEIN ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002

Figure 7 ANTIBODY PROTEIN ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)

• Peptide Biochip Protein Array Technology Research Market Players

Table 47 PEPTIDE BIOCHIP TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)

• Protein Biochip Array Technology Research Market Players

Table 48 PROTEIN BIOCHIP ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)

Figure 8 PROTEIN BIOCHIP ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)

• Solution Bead/Particle Protein Array Technology Research Market Players

Table 49 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002

• Content Specific Research Protein Array Market Players
  • Cytokines
  • Kinases
• CLINICAL PROTEIN ARRAY TECHNOLOGY

Table 50 PROTEIN ARRAY TECHNOLOGY CLINICAL MARKET SALES, THROUGH 2007 ($ MILLIONS)

• PROTEIN ARRAY CONTENT DEVELOPMENT

Table 51 SELECTED AVAILABLE PROTEIN ARRAY TARGET MARKET DATA ($ MILLIONS)

• CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY PLAYERS

Table 52 CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY PLAYERS, BY APPLICATION

• CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY MARKETS
  • Allergy
  • Alzheimer's Disease
  • Angiogenesis

Table 53 ANGIOGENESIS-DEPENDENT DISEASES

• Cancer
• Drugs of Abuse
• Fertility
• Immune/Autoimmune Diseases
• Obesity
• Pathogens
• Therapeutic Drugs
• Tissue Typing/Cardiac Marker
• Thyroid
• CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY DEVELOPERS

Table 54 CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY DEVELOPERS, BY APPLICATION

• SPOTTING ARRAYERS
  • NEW DEVELOPMENTS
• PROTEIN BIOCHIP ENHANCERS
• BIOINFORMATICS
  • TECHNOLOGY
  • DEVELOPMENT
  • CLINICAL DIAGNOSTIC APPLICATIONS
  • BIOINFORMATIC DATA STANDARDS

PATENTS

Table 55 PROTEIN ARRAY TECHNOLOGY PATENT FILINGS, 1989-2002

• ANTIBODY ARRAY PATENTS

Table 56 ANTIBODY ARRAY PATENTS

Table 57 ANTIBODY ARRAY PATENTS BY ASSIGNEE, 2000-2002

• PEPTIDE BIOCHIP ARRAY PATENTS

Table 58 PEPTIDE BIOCHIP ARRAY PATENTS

Table 59 PEPTIDE PATENT ARRAYS BY ASSIGNEE, 1999-2002

• PROTEIN BIOCHIP ARRAY PATENTS

Table 60 NUMBER OF NEW PROTEIN BIOCHIP ARRAY PATENTS

Table 61 PROTEIN BIOCHIP ARRAY PATENTS, 1989-2002

Table 61 (CONTINUED)

Table 61 (CONTINUED)

Table 61 (CONTINUED)

Table 62 PROTEIN BIOCHIP ARRAY PATENTS BY ASSIGNEE, 1989-2002

Table 62 (CONTINUED)

• CIPHERGEN, LUMICYTE, MAS PATENT DISPUTE
• PROTEIN SOLUTION BEAD/PARTICLE ARRAY PATENTS

Table 63 NUMBER OF NEW PROTEIN BIOCHIP ARRAY PATENTS, 1998-2002

Table 64 PROTEIN SOLUTION BEAD/PARTICLE ARRAY PATENTS

Table 64 (CONTINUED)

Table 65 PROTEIN SOLUTION BEAD/PARTICLE ARRAY PATENTS BY ASSIGNEE, 1998-2002

APPENDIX I - PROTEIN ARRAY COMPANY PROFILES

• ANTIBODY ARRAY COMPANIES
  • BD BIOSCIENCES CLONTECH
  • DOMANTIS LTD.
  • HYPROMATRIX, INC.
  • MILAGEN, INC.
  • PERKIN-ELMER LIFE SCIENCES/PACKARD BIOSCIENCE
  • PANOMICS, INC.
  • PIERCE BIOTECHNOLOGY, INC.
  • RAYBIOTECH, INC.
  • SCHLEICHER & SCHUELL BIOSCIENCE, INC.
• PROTEIN BIOCHIP ARRAY COMPANIES
  • ADVANCED ARRAY TECHNOLOGY S.A.
  • AFFIBODY AB
  • ASPIRA BIOSYSTEMS, INC.
  • AXCELL BIOSCIENCES CORP.
  • BIACORE, INC.
  • BIOCEPT, INC
  • BIOFORCE NANOSCIENCES, INC.
  • CIPHERGEN BIOSYSTEMS, INC.
  • GENOMIC SOLUTIONS, INC.
  • HTS BIOSYTEMS
  • HYBRIGENICS SA
  • LUMICYTE, INC.
  • MESO SCALE DISCOVERY
  • METRIGENIX, INC.
  • MIRAGENE, INC.
  • MOLECULAR STAGING, INC.
  • MOREWOOD MOLECULAR, INC.
  • NEXTGEN SCIENCES LTD.
  • PERKIN-ELMER LIFE SCIENCES/PACKARD BIOSCIENCE
  • PROLINX, INC.
  • PROTOMETRIX
  • PROTIVERIS INC.
  • RANDOX LABORATORIES LTD.
  • SOMALOGIC, INC.
  • SURFACE LOGIX, INC.
  • TELECHEM INTERNATIONAL, INC.
  • ZEPTOSENS AG
  • ZYOMYX, INC.
• PROTEIN BIOCHIP ARRAY ENHANCER COMPANIES
  • ADVALYTIX
  • GENICON SCIENCES CORP.
• PEPTIDE ARRAY COMPANIES
  • JERINI AG
  • PEPSCAN
  • XEOTRON CORP.
• SOLUTION BEAD ARRAY COMPANIES
  • BIOPLEX CORP. (CRYSTALPLEX CORP.)
  • LUMINEX CORP.
  • NANOPLEX TECHNOLOGIES, INC.
  • QUANTUMDOT CORP.
  • SMARTBEAD TECHNOLOGIES LTD.
  • VERITY BIOSYSTEMS
• PROTEIN ARRAY SPOTTING INSTRUMENT COMPANIES
  • DIGITALGENE BIOSCIENCES, LTD.
  • TELECHEM INTERNATIONAL
    • Telechem International (Continued)

APPENDIX II - ASSOCIATIONS

• HUMAN PROTEOME ORGANIZATION (HUPO)
• BIOPAX
• BIOLOGICAL PATHWAYS
• PLASMA PROTEOME INSTITUTE (PPI)
• PROTEOME SOCIETY

 

LIST OF TABLES

• Summary Table:
  WORLDWIDE PROTEIN ARRAY TECHNOLOGY SALES BY MARKET SEGMENT, THROUGH 2007 ($ Millions)
• Table 1 PROTEIN CAPTURE MOLECULES AND TARGETS
• Table 2 R&D SPENDING IN THE GLOBAL PHARMACEUTICAL INDUSTRY, 1980-2002 ($ MILLIONS)
• Table 3 DISTRIBUTION OF DRUG RESEARCH COSTS
• Table 4 DRUGS APPROVED BY THE FDA, 1993-2002 (# DRUGS)
• Table 5 PROTEIN ARRAY TECHNOLOGY COMPANIES AND MARKET SHARES, BY CATEGORY, 2002
• Table 6 WORLDWIDE PROTEIN ARRAY TECHNOLOGY SALES BY CATEGORY, THROUGH 2007 ($ MILLIONS)
• Table 7 WORLDWIDE DISTRIBUTION OF PROTEIN ARRAY TECHNOLOGY COMPANIES BY CATEGORY, 2002
• Table 8 COMPANIES WORLDWIDE THAT LAUNCHED PROTEIN ARRAY TECHNOLOGY PRODUCTS, BY CATEGORY, 1999-2002
• Table 9 PROTEIN ARRAY TECHNOLOGY PRODUCT LAUNCHES, BY CATEGORY, 2002 (%)
• Table 10 COMPANIES THAT LAUNCHED ANTIBODY ARRAY PRODUCTS, 1999-2002
• Table 11 WORLDWIDE ANTIBODY ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)
• Table 12 ANTIBODY ARRAY TECHNOLOGY PRODUCT LAUNCHES, BY COMPANY, 2000-2002
• Table 13 SUMMARY OF ANTIBODY ARRAY TECHNOLOGY FEATURES, BY COMPANY
• Table 14 ANTIBODY ARRAY SURFACE MATERIAL USE, BY TYPE, 2002
• Table 15 ANTIBODY ARRAY DETECTION METHOD USE BY TYPE, 2002
• Table 16 ANTIBODY ARRAY TECHNOLOGY COMPANY MARKET SHARE, 2002
• Table 17 APPLICATIONS/TYPES OF ANTIBODY ARRAY TECHNOLOGY, BY COMPANY
• Table 18 WORLDWIDE PEPTIDE BIOCHIP ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)
• Table 19 PEPTIDE ARRAY PRODUCT LAUNCHES, 1999-2002
• Table 20 PEPTIDE BIOCHIP TECHNOLOGY LAUNCHES BY COMPANY, 2000-2004
• Table 21 PEPTIDE BIOCHIP TECHNOLOGY FEATURES, BY COMPANY
• Table 22 PEPTIDE ARRAY SURFACE MATERIAL USE, BY COMPANY
• Table 23 PEPTIDE ARRAY DETECTION METHOD BY COMPANY
• Table 24 WORLDWIDE PROTEIN BIOCHIP ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)
• Table 25 PROTEIN BIOCHIP TECHNOLOGY COMPANIES
• Table 26 COMPANIES THAT LAUNCHED PROTEIN BIOCHIPS, 1999-2002
• Table 27 PROTEIN BIOCHIP PRODUCT LAUNCHES BY COMPANY, 1999-2002
• Table 28 PROTEIN BIOCHIP ARRAY PRODUCTS/SERVICES FEATURES BY COMPANY
• Table 29 PROTEIN BIOCHIP ARRAY TECHNOLOGY COMPANY MARKET SHARES, 2002 (%)
• Table 30 COMPANIES WITH PROTEIN BIOCHIP ARRAY TECHNOLOGY IN DEVELOPMENT
• Table 31 PROTEIN BIOCHIP ARRAY SURFACE MATERIAL USE, BY TYPE, 2002
• Table 32 PROTEIN BIOCHIP ARRAY SURFACE MATERIAL DESCRIPTION, BY COMPANY
• Table 33 PROTEIN BIOCHIP ARRAY DETECTION METHOD USE BY TYPE, 2002
• Table 34 PROTEIN BIOCHIP ARRAY DETECTION METHOD DESCRIPTION, BY COMPANY
• Table 35 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)
• Table 36 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY COMPANIES
• Table 37 SUMMARY OF SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY FEATURES BY COMPANY
• Table 38 SOLUTION BEAD/PARTICLE PROTEIN ARRAY MATERIAL TECHNOLOGY USE BY TYPE, 2002
• Table 39 SOLUTION BEAD/PARTICLE PROTEIN ARRAY DETECTION TECHNOLOGY USE BY TYPE, 2002
• Table 40 SOLUTION BEAD/PARTICLE ARRAY COMPANY MARKET SHARE, 2002
• Table 41 LUMINEX RESEARCH/DRUG DISCOVERY PARTNERS AND APPLICATIONS
• Table 42 LUMINEX DIAGNOSTIC PARTNERS AND APPLICATIONS
• Table 43 SOLUTION BEAD/PARTICLE COLLABORATIONS, BY APPLICATION AREA, 2002
• Table 44 PROTEIN ARRAY APPLICATION SECTOR SALES, THROUGH 2007 ($ MILLIONS)
• Table 45 RESEARCH PROTEIN ARRAY TECHNOLOGY SALES BY CATEGORY, THROUGH 2007 ($ MILLIONS)
• Table 46 ANTIBODY PROTEIN ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002
• Table 47 PEPTIDE BIOCHIP TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)
• Table 48 PROTEIN BIOCHIP ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)
• Table 49 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)
• Table 50 PROTEIN ARRAY TECHNOLOGY CLINICAL MARKET SALES, THROUGH 2007 ($ MILLIONS)
• Table 51 SELECTED AVAILABLE PROTEIN ARRAY TARGET MARKET DATA ($ MILLIONS)
• Table 52 CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY PLAYERS, BY APPLICATION
• Table 52 (CONTINUED)
• Table 53 ANGIOGENESIS-DEPENDENT DISEASES
• Table 54 CONTENT-SPECIFIC PROTEIN ARRAY TECHNOLOGY DEVELOPERS, BY APPLICATION
• Table 55 PROTEIN ARRAY TECHNOLOGY PATENT FILINGS, 1989-2002
• Table 56 ANTIBODY ARRAY PATENTS
• Table 57 ANTIBODY ARRAY PATENTS BY ASSIGNEE, 2000-2002
• Table 58 PEPTIDE BIOCHIP ARRAY PATENTS
• Table 59 PEPTIDE PATENT ARRAYS BY ASSIGNEE, 1999-2002
• Table 60 NUMBER OF NEW PROTEIN BIOCHIP ARRAY PATENTS
• Table 61 PROTEIN BIOCHIP ARRAY PATENTS, 1989-2002
• Table 62 PROTEIN BIOCHIP ARRAY PATENTS BY ASSIGNEE, 1989-2002
• Table 63 NUMBER OF NEW PROTEIN BIOCHIP ARRAY PATENTS, 1998-2002
• Table 64 PROTEIN SOLUTION BEAD/PARTICLE ARRAY PATENTS
• Table 65 PROTEIN SOLUTION BEAD/PARTICLE ARRAY PATENTS BY ASSIGNEE, 1998-2002  

LIST OF FIGURES

• Summary Figure:
  WORLDWIDE PROTEIN ARRAY TECHNOLOGY SALES BY MARKET SEGMENT, 2000-2007 ($ Millions)
• Figure 1 WORLDWIDE ANTIBODY ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)
• Figure 2 ANTIBODY ARRAY TECHNOLOGY COMPANY MARKET SHARE, 2002 (%)
• Figure 3 WORLDWIDE PEPTIDE BIOCHIP ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)
• Figure 4 WORLDWIDE PROTEIN BIOCHIP ARRAY TECHNOLOGY SALES, 2000-2007 ($ MILLIONS)
• Figure 5 PROTEIN BIOCHIP ARRAY TECHNOLOGY COMPANY MARKET SHARES, 2002 (%)
• Figure 6 SOLUTION BEAD/PARTICLE PROTEIN ARRAY TECHNOLOGY SALES, THROUGH 2007 ($ MILLIONS)
• Figure 7 ANTIBODY PROTEIN ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)
• Figure 8 PROTEIN BIOCHIP ARRAY TECHNOLOGY RESEARCH MARKET SHARE BY COMPANY, 2002 (%)